Browsing Bergen Open Research Archive by Author "Mustafa, Tehmina"
Now showing items 1-20 of 27
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Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice
Mortensen, Rasmus; Clemmensen, Helena Strand; Woodworth, Joshua S.; Therkelsen, Marie Louise; Mustafa, Tehmina; Tonby, Kristian; Jenum, Synne; Agger, Else Marie; Dyrhol-Riise, Anne Ma; Andersen, Peter (Peer reviewed; Journal article, 2019)Tuberculosis, caused by infection with Mycobacterium tuberculosis (Mtb), kills over 1.6 million people each year despite availability of antibiotics. The increase in drug resistant Mtb strains is a major public health ... -
Diagnosis of extrapulmonary tuberculosis using the MPT64 antigen detection test in a high-income low tuberculosis prevalence setting
Hoel, Ida Marie; Sviland, Lisbeth; Syre, Heidi; Dyrhol-Riise, Anne Ma; Skarstein, Ingerid; Jebsen, Peter Wilhelm; Jørstad, Melissa Davidsen; Wiker, Harald G; Mustafa, Tehmina (Journal article; Peer reviewed, 2020)Background Extrapulmonary tuberculosis (EPTB) poses diagnostic challenges due to the paucibacillary nature of the disease. The immunochemistry-based MPT64 antigen detection test (MPT64 test) has shown promising results ... -
Differential in vivo expression of mycobacterial antigens in Mycobacterium tuberculosis infected lungs and lymph node tissues
Mustafa, Tehmina; Leversen, Nils Anders; Sviland, Lisbet; Wiker, Harald G. (Peer reviewed; Journal article, 2014-10-03)Background: The clinical course of tuberculosis (TB) infection, bacterial load and the morphology of lesions vary between pulmonary and extrapulmonary TB. Antigens expressed in abundance during infection could represent ... -
Evaluation of treatment response in extrapulmonary tuberculosis in a low-resource setting
Jørstad, Melissa Davidsen; Dyrhol-Riise, Anne Ma; Aßmus, Jörg; Marijani, Msafiri; Sviland, Lisbeth; Mustafa, Tehmina (Peer reviewed; Journal article, 2019-05-16)Background Diagnosing extrapulmonary tuberculosis (EPTB) is challenging and many patients are initiated on empirical anti-TB treatment without a laboratory confirmed diagnosis. Monitoring treatment response is thus important ... -
Evidence for waning of latency in a cohort study of tuberculosis
Wiker, Harald G.; Mustafa, Tehmina; Bjune, Gunnar Aksel; Harbo, Morten (Peer reviewed; Journal article, 2010-02-23)Background To investigate how the risk of active tuberculosis disease is influenced by time since original infection and to determine whether the risk of reactivation of tuberculosis increases or decreases with age. Methods ... -
Extrapulmonary tuberculosis in Pakistan- A nation-wide multicenter retrospective study
Tahseen, Sabira; Khanzada, Faisal Masood; Baloch, Aurangzaib Quadir; Abbas, Qasim; Bhutto, Mansoor Manzoor; Alizai, Ahmad Wali; Zaman, Shah; Qasim, Zahida; Durrani, Muhammad Najeeb; Farough, M. Khalid; Ambreen, Atiqa; Safdar, Nauman; Mustafa, Tehmina (Journal article; Peer reviewed, 2020)Background Pakistan is fifth among high burden countries for tuberculosis. A steady increase is seen in extrapulmonary tuberculosis (EPTB), which now accounts for 20% of all notified TB cases. There is very limited ... -
Host biomarkers for monitoring therapeutic response in extrapulmonary tuberculosis
Ambreen, Atiqa; khaliq, Aasia; Naqvi, Syed Zeeshan Haider; Tahir, Amna; Mustafa, Manal; Chaudhary, Safee Ullah; Mirza, Shaper; Mustafa, Tehmina (Journal article; Peer reviewed, 2021)Purpose The aim of this study was to explore the utility of inflammatory biomarkers in the peripheral blood to predict response to treatment in extrapulmonary tuberculosis (EPTB). Methods A Luminex xMAP-based multiplex ... -
Immunocytochemical detection of Mycobacterium Tuberculosis complex specific antigen, MPT64, improves diagnosis of tuberculous lymphadenitis and tuberculous pleuritis
Tadele, Agerie; Beyene, Demissew Balcha; Hussein, Jemal; Gemechu, Tuffa; Birhanu, Asaye; Mustafa, Tehmina; Tsegaye, Aster; Aseffa, Abraham; Sviland, Lisbet (Peer reviewed; Journal article, 2014-11-25)Background: A rapid, sensitive and accurate laboratory diagnosis is of prime importance in suspected extrapulmonary tuberculosis (EPTB) cases. However, traditional techniques for the detection of acid-fast bacilli have ... -
Immunohistochemical diagnosis of abdominal and lymph node tuberculosis by detecting Mycobacterium tuberculosis complex specific antigen MPT64
Purohit, Manju Raj; Mustafa, Tehmina; Wiker, Harald G.; Mørkve, Odd; Sviland, Lisbet (Peer reviewed; Journal article, 2007-09-25)Background: The aim of this study was to evaluate the diagnostic potential of immunohistochemistry using an antibody to the secreted mycobacterial antigen MPT64, in abdominal and lymph node tuberculosis. Methods: We used ... -
In Situ Expression of CD40, CD40L (CD154), IL-12, TNF-a, IFN-g and TGF-b1 in Murine Lungs during Slowly Progressive Primary Tuberculosis
Mogga, S. J.; Mustafa, Tehmina; Sviland, Lisbet; Nilsen, Rune (Journal article, 2003-09)The distribution and expression of CD40, its ligand CD40L (154) and related cytokines interleukin-12 (IL-12), tumour necrosis factor-α (TNF-α), interferon-γ (IFN-γ) and transforming growth factor-β1 (TGF-β1) were studied ... -
In Situ Expression of Cytokines and Cellular Phenotypes in the Lungs of Mice with Slowly Progressive Primary Tuberculosis
Mustafa, Tehmina; Phyu, S.; Nilsen, Rune; Jonsson, Roland; Bjune, Gunnar Aksel (Peer reviewed; Journal article, 2000-06)The cellular phenotypes and the expression of cytokines were studied in the lungs of mice, using immunohistochemistry, during different phases of slowly progressive primary murine tuberculosis infection. During the first ... -
Increased Bcl-2 and Reduced Bax Expression in Infected Macrophages in Slowly Progressive Primary Murine Mycobacterium tuberculosis Infection
Mogga, S. J.; Mustafa, Tehmina; Sviland, Lisbet; Nilsen, Rune (Peer reviewed; Journal article, 2002-10)Mycobacterium tuberculosis (MTB) persists in host macrophages (Mφs) because it has developed mechanisms to escape Mφ killing. In vitro studies have shown that MTB can induce and inhibit apoptosis by causing the expression ... -
Increased Expression of Fas Ligand in Human Tuberculosis and Leprosy Lesions: a Potential Novel Mechanism of Immune Evasion in Mycobacterial Infection
Mustafa, Tehmina; Bjune, Gunnar Aksel; Jonsson, Roland; Pando, R. Hernandez; Nilsen, Rune (Peer reviewed; Journal article, 2001-12)To study the location and mechanism of apoptosis within the human tuberculosis (TB) and leprosy lesions, parallel sections were analyzed for mycobacterial antigens (M.Ag), Fas ligand (FasL), Fas, CD68 and Mac387 by ... -
IP-10 dried blood spots assay monitoring treatment efficacy in extrapulmonary tuberculosis in a low-resource setting
Hoel, Ida Marie; Jørstad, Melissa Davidsen; Marijani, Msafiri; Ruhwald, Morten; Mustafa, Tehmina; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2019-03-07)Treatment efficacy is difficult to evaluate in extrapulmonary tuberculosis (EPTB) patients. Interferon-γ inducible protein (IP-)10 has been suggested as a biomarker for response to treatment. We have investigated if IP-10 ... -
Isolation of non-tuberculous mycobacteria among tuberculosis patients, a study from a tertiary care hospital in Lahore, Pakistan
Karamat, Asifa; Ambreen, Atiqa; Ishtiaq, Aamira; Tahseen, Sabira; Rahman, Muhammad Aqeelur; Mustafa, Tehmina (Journal article; Peer reviewed, 2021)Background There is scarce knowledge on the prevalence of diseases caused by non-tuberculous mycobacteria (NTM) in Pakistan. In the absence of culture and identification, acid-fast bacilli (AFB) causing NTM disease are ... -
Isoniazid resistance profile and associated levofloxacin and pyrazinamide resistance in rifampicin resistant and sensitive isolates/ from pulmonary and extrapulmonary tuberculosis patients in Pakistan: A laboratory based surveillance study 2015-19
Tahseen, Sabira; Khanzada, Faisal Masood; Rizvi, Alamdar Hussain; Qadir, Mahmood; Ghazal, Aisha; Baloch, Aurangzaib Quadir; Mustafa, Tehmina (Journal article; Peer reviewed, 2020)Background Pakistan is among top five high burden countries for tuberculosis and drug resistant TB. Among rifampicin sensitive new pulmonary TB (PTB), prevalence of isoniazid resistance is 8.3% (95%CI: 7.0–10.7) and ... -
A Mouse Model for Latent Tuberculosis
Phyu, S.; Mustafa, Tehmina; Hofstad, T.; Nilsen, Rune; Fosse, R.; Bjune, Gunnar Aksel (Peer reviewed; Journal article, 1998-06)The aim of the study was to establish a reproducible murine model for latent tuberculosis. We propose an operational definition of latent murine tuberculosis as a stable Mycobacterium tuberculosis count in lungs and spleens ... -
A Mouse Model for Slowly Progressive Primary Tuberculosis
Mustafa, Tehmina; Phyu, S.; Nilsen, Rune; Jonsson, Roland; Bjune, Gunnar Aksel (Journal article, 1999-08)The progression from primary Mycobacterium tuberculosis infection to disease is usually slow in humans. The aim of this study was to develop and characterize a mouse model for slowly progressive primary tuberculosis, using ... -
MPT64 antigen detection test improves routine diagnosis of extrapulmonary tuberculosis in a low-resource setting: A study from the tertiary care hospital in Zanzibar
Jørstad, Melissa Davidsen; Marijani, Msafiri; Dyrhol-Riise, Anne Ma; Sviland, Lisbeth; Mustafa, Tehmina (Peer reviewed; Journal article, 2018-05-09)Background: Extrapulmonary tuberculosis (EPTB) is a diagnostic challenge. An immunochemistry-based MPT64 antigen detection test (MPT64 test) has reported higher sensitivity in the diagnosis of EPTB compared with conventional ... -
Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients
Mustafa, Tehmina; Brokstad, Karl Albert; Mfinanga, Sayoki Godfrey M.; Wiker, Harald G (Peer reviewed; Journal article, 2015)Objectives. Tuberculous lymphadenitis is the most common formof extrapulmonary tuberculosis (TB) with a female and paediatric preponderance, postulated to be due to differences in the immune response. The aim of this study ...