Blar i Bergen Open Research Archive på forfatter "Mustafa, Tehmina"
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Care-seeking pathways and diagnostic delays in extrapulmonary TB patients
Wali, Ahmad; Safdar, Nauman; Ambreen, Atiqa; Tahseen, Sabira; Mustafa, Tehmina (Journal article; Peer reviewed, 2023)SETTING: This study was conducted at a private tertiary hospital engaged with the TB control programme in the city of Lahore, Pakistan. OBJECTIVE: To assess the healthcare-seeking pathways, different delays and factors ... -
Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice
Mortensen, Rasmus; Clemmensen, Helena Strand; Woodworth, Joshua S.; Therkelsen, Marie Louise; Mustafa, Tehmina; Tonby, Kristian; Jenum, Synne; Agger, Else Marie; Dyrhol-Riise, Anne Ma; Andersen, Peter (Peer reviewed; Journal article, 2019)Tuberculosis, caused by infection with Mycobacterium tuberculosis (Mtb), kills over 1.6 million people each year despite availability of antibiotics. The increase in drug resistant Mtb strains is a major public health ... -
Diagnosis of extrapulmonary tuberculosis using the MPT64 antigen detection test in a high-income low tuberculosis prevalence setting
Hoel, Ida Marie; Sviland, Lisbeth; Syre, Heidi; Dyrhol-Riise, Anne Ma; Skarstein, Ingerid; Jebsen, Peter Wilhelm; Jørstad, Melissa Davidsen; Wiker, Harald G; Mustafa, Tehmina (Journal article; Peer reviewed, 2020)Background Extrapulmonary tuberculosis (EPTB) poses diagnostic challenges due to the paucibacillary nature of the disease. The immunochemistry-based MPT64 antigen detection test (MPT64 test) has shown promising results ... -
Differential in vivo expression of mycobacterial antigens in Mycobacterium tuberculosis infected lungs and lymph node tissues
Mustafa, Tehmina; Leversen, Nils Anders; Sviland, Lisbet; Wiker, Harald G. (Peer reviewed; Journal article, 2014-10-03)Background: The clinical course of tuberculosis (TB) infection, bacterial load and the morphology of lesions vary between pulmonary and extrapulmonary TB. Antigens expressed in abundance during infection could represent ... -
Evaluation of treatment response in extrapulmonary tuberculosis in a low-resource setting
Jørstad, Melissa Davidsen; Dyrhol-Riise, Anne Ma; Aßmus, Jörg; Marijani, Msafiri; Sviland, Lisbeth; Mustafa, Tehmina (Peer reviewed; Journal article, 2019-05-16)Background Diagnosing extrapulmonary tuberculosis (EPTB) is challenging and many patients are initiated on empirical anti-TB treatment without a laboratory confirmed diagnosis. Monitoring treatment response is thus important ... -
Evidence for waning of latency in a cohort study of tuberculosis
Wiker, Harald G.; Mustafa, Tehmina; Bjune, Gunnar Aksel; Harbo, Morten (Peer reviewed; Journal article, 2010-02-23)Background To investigate how the risk of active tuberculosis disease is influenced by time since original infection and to determine whether the risk of reactivation of tuberculosis increases or decreases with age. Methods ... -
Extrapulmonary tuberculosis in Pakistan- A nation-wide multicenter retrospective study
Tahseen, Sabira; Khanzada, Faisal Masood; Baloch, Aurangzaib Quadir; Abbas, Qasim; Bhutto, Mansoor Manzoor; Alizai, Ahmad Wali; Zaman, Shah; Qasim, Zahida; Durrani, Muhammad Najeeb; Farough, M. Khalid; Ambreen, Atiqa; Safdar, Nauman; Mustafa, Tehmina (Journal article; Peer reviewed, 2020)Background Pakistan is fifth among high burden countries for tuberculosis. A steady increase is seen in extrapulmonary tuberculosis (EPTB), which now accounts for 20% of all notified TB cases. There is very limited ... -
Factors associated with hospitalization and mortality in adult and pediatric extrapulmonary tuberculosis at a tertiary care hospital in Central India
Helle, Ole Magnus Bjørgaas; Kanthali, Mala; Grønningen, Erlend; Hassan, Shoaib; Purohit, Manju Raj; Mustafa, Tehmina (Journal article; Peer reviewed, 2024)Background Comorbidities complicate the management of tuberculosis (TB) and have become an essential part of the end TB strategy to eradicate TB. However, pulmonary TB has received the most attention, and little is known ... -
Host biomarkers for monitoring therapeutic response in extrapulmonary tuberculosis
Ambreen, Atiqa; khaliq, Aasia; Naqvi, Syed Zeeshan Haider; Tahir, Amna; Mustafa, Manal; Chaudhary, Safee Ullah; Mirza, Shaper; Mustafa, Tehmina (Journal article; Peer reviewed, 2021)Purpose The aim of this study was to explore the utility of inflammatory biomarkers in the peripheral blood to predict response to treatment in extrapulmonary tuberculosis (EPTB). Methods A Luminex xMAP-based multiplex ... -
Identification of host biomarkers from dried blood spots for monitoring treatment response in extrapulmonary tuberculosis
Khalid, Shizza; Ambreen, Atiqa; Khaliq, Aasia; Ullah, Hafeez; Mustafa, Manal; Mustafa, Tehmina (Journal article; Peer reviewed, 2023)There is a lack of objective tools for monitoring treatment response in extrapulmonary tuberculosis (EPTB). This study aimed to explore the utility of inflammatory biomarkers from the dry blood spots (DBS) as a tool for ... -
Immunochemistry-Based Diagnosis of Extrapulmonary Tuberculosis: A Strategy for Large-Scale Production of MPT64-Antibodies for Use in the MPT64 Antigen Detection Test
Hoel, Ida Marie; Ali, Iman A Mohammed; Ishtiaq, Sheeba; Sviland, Lisbet; Wiker, Harald Gotten; Mustafa, Tehmina (Journal article; Peer reviewed, 2021)Tuberculosis (TB) is a global health problem. The immunohistochemistry (IHC)-based MPT64 antigen detection test has shown promising results for diagnosing extrapulmonary TB in previous studies. However, the anti-MPT64 ... -
Immunocytochemical detection of Mycobacterium Tuberculosis complex specific antigen, MPT64, improves diagnosis of tuberculous lymphadenitis and tuberculous pleuritis
Tadele, Agerie; Beyene, Demissew Balcha; Hussein, Jemal; Gemechu, Tuffa; Birhanu, Asaye; Mustafa, Tehmina; Tsegaye, Aster; Aseffa, Abraham; Sviland, Lisbet (Peer reviewed; Journal article, 2014-11-25)Background: A rapid, sensitive and accurate laboratory diagnosis is of prime importance in suspected extrapulmonary tuberculosis (EPTB) cases. However, traditional techniques for the detection of acid-fast bacilli have ... -
Immunohistochemical diagnosis of abdominal and lymph node tuberculosis by detecting Mycobacterium tuberculosis complex specific antigen MPT64
Purohit, Manju Raj; Mustafa, Tehmina; Wiker, Harald G.; Mørkve, Odd; Sviland, Lisbet (Peer reviewed; Journal article, 2007-09-25)Background: The aim of this study was to evaluate the diagnostic potential of immunohistochemistry using an antibody to the secreted mycobacterial antigen MPT64, in abdominal and lymph node tuberculosis. Methods: We used ... -
Improved diagnosis of extrapulmonary tuberculosis in adults with and without HIV in Mbeya, Tanzania using the MPT64 antigen detection test
Grønningen, Erlend; Nanyaro, Marywinnie; Sviland, Lisbet; Ngadaya, Esther Stanslaus; Muller, William; Torres, Lisete; Mfinanga, Sayoki; Mustafa, Tehmina (Journal article; Peer reviewed, 2022-11-29)Extrapulmonary tuberculosis (EPTB) in People Living with HIV (PLWHIV) is a diagnostic challenge. Our immunochemistry based MPT64 antigen detection test has shown improved sensitivity compared to current laboratory tests ... -
Improving diagnosis of tuberculous lymphadenitis by combination of cytomorphology and MPT64 immunostaining on cell blocks from the fine needle aspirates
Ulain, Noor; Ali, Asif; Khan, Momin; Ullah, Zakir; Shaheen, Lubna; Shareef, Naveed; Yasir, Muhammad; Mustafa, Tehmina (Journal article; Peer reviewed, 2022)Background Extra pulmonary tuberculosis (EPTB) constitutes 18% of all tuberculosis (TB) cases and tuberculous lymphadenitis (TBL) constitutes 20–40% of EPTB. Diagnosis of TBL is challenging because of the paucibacillary ... -
In Situ Expression of CD40, CD40L (CD154), IL-12, TNF-a, IFN-g and TGF-b1 in Murine Lungs during Slowly Progressive Primary Tuberculosis
Mogga, S. J.; Mustafa, Tehmina; Sviland, Lisbet; Nilsen, Rune (Journal article; Peer reviewed, 2003-09)The distribution and expression of CD40, its ligand CD40L (154) and related cytokines interleukin-12 (IL-12), tumour necrosis factor-α (TNF-α), interferon-γ (IFN-γ) and transforming growth factor-β1 (TGF-β1) were studied ... -
In Situ Expression of Cytokines and Cellular Phenotypes in the Lungs of Mice with Slowly Progressive Primary Tuberculosis
Mustafa, Tehmina; Phyu, S.; Nilsen, Rune; Jonsson, Roland; Bjune, Gunnar Aksel (Peer reviewed; Journal article, 2000-06)The cellular phenotypes and the expression of cytokines were studied in the lungs of mice, using immunohistochemistry, during different phases of slowly progressive primary murine tuberculosis infection. During the first ... -
Increased Bcl-2 and Reduced Bax Expression in Infected Macrophages in Slowly Progressive Primary Murine Mycobacterium tuberculosis Infection
Mogga, S. J.; Mustafa, Tehmina; Sviland, Lisbet; Nilsen, Rune (Peer reviewed; Journal article, 2002-10)Mycobacterium tuberculosis (MTB) persists in host macrophages (Mφs) because it has developed mechanisms to escape Mφ killing. In vitro studies have shown that MTB can induce and inhibit apoptosis by causing the expression ... -
Increased Expression of Fas Ligand in Human Tuberculosis and Leprosy Lesions: a Potential Novel Mechanism of Immune Evasion in Mycobacterial Infection
Mustafa, Tehmina; Bjune, Gunnar Aksel; Jonsson, Roland; Pando, R. Hernandez; Nilsen, Rune (Peer reviewed; Journal article, 2001-12)To study the location and mechanism of apoptosis within the human tuberculosis (TB) and leprosy lesions, parallel sections were analyzed for mycobacterial antigens (M.Ag), Fas ligand (FasL), Fas, CD68 and Mac387 by ... -
IP-10 dried blood spots assay monitoring treatment efficacy in extrapulmonary tuberculosis in a low-resource setting
Hoel, Ida Marie; Jørstad, Melissa Davidsen; Marijani, Msafiri; Ruhwald, Morten; Mustafa, Tehmina; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2019-03-07)Treatment efficacy is difficult to evaluate in extrapulmonary tuberculosis (EPTB) patients. Interferon-γ inducible protein (IP-)10 has been suggested as a biomarker for response to treatment. We have investigated if IP-10 ...