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Loss of epigenetic suppression of retrotransposons with oncogenic potential in aging mammary luminal epithelial cells
(Journal article; Peer reviewed, 2023)A primary function of DNA methylation in mammalian genomes is to repress transposable elements (TEs). The widespread methylation loss that is commonly observed in cancer cells results in the loss of epigenetic repression ... -
Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae
(Journal article; Peer reviewed, 2023)Protein N-terminal (Nt) acetylation is one of the most abundant modifications in eukaryotes, covering ~50-80 % of the proteome, depending on species. Cells with defective Nt-acetylation display a wide array of phenotypes ... -
Loss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma
(Journal article; Peer reviewed, 2020)Background We previously showed a tumor‐suppressive function of S100A14 in oral squamous cell carcinoma (OSCC). This study aimed to examine the prognostic significance and differentiation‐related function of S100A14 in ... -
Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway
(Journal article; Peer reviewed, 2022)Heterozygous loss-of-function (LoF) mutations in SETD1A, which encodes a subunit of histone H3 lysine 4 methyltransferase, cause a neurodevelopmental syndrome and increase the risk for schizophrenia. Using CRISPR-Cas9, we ... -
Lossy Kernelization of Same-Size Clustering
(Journal article; Peer reviewed, 2023)In this work, we study the k-median clustering problem with an additional equal-size constraint on the clusters from the perspective of parameterized preprocessing. Our main result is the first lossy (2-approximate) ... -
Lost in Translation? Multiple Discursive Strategies and the Interpretation of Sustainability in the Norwegian Salmon Farming Industry
(Journal article; Peer reviewed, 2020-04-04)The term ‘sustainability’ is vague and open to interpretation. In this paper we analyze how firms use the term in an effort to make the concept their own, and how it becomes a premise for further decisions, by applying a ... -
Lov til kjærlighet. En studie av høringsuttalelsene til innføring av begrepet kjærlighet i barnevernloven
(Journal article; Peer reviewed, 2020)Barnevernloven ble i 2018 endret til å inkludere begrepet kjærlighet. At loven nå inneholder et begrep som tradisjonelt er blitt brukt for å beskrive relasjoner innad i familien, har vært omstridt. I artikkelen presenterer ... -
Low and unequal use of outpatient health services in public primary health care facilities in southern Ethiopia: a facility-based cross-sectional study
(Journal article; Peer reviewed, 2021)Background: Outpatient department visits per individual for each year are one of the core indicators of healthcare delivery to assess accessibility or quality of services. In addition, this study aimed to assess health ... -
Low birthweight is associated with lower glomerular filtration rate in middle-aged mainly healthy women
(Journal article; Peer reviewed, 2020)Background Low birthweight (LBW) has been shown to increase the risk of severe kidney disease. Studies have also shown associations between LBW and lower estimated glomerular filtration rate (GFR) in young adults. In this ... -
Low BMI, but not high BMI, influences the timing of puberty in boys
(Journal article; Peer reviewed, 2021)Background Previous studies investigating the association between weight status and onset of puberty in boys have been equivocal. It is currently unclear to what extent weight class influences puberty onset and ... -
The low country saints of the Næstved calendar
(Journal article; Peer reviewed, 2023)The Næstved Calendar (Copenhagen, Det Kongelige Bibliotek, E don. var. 52 2º), an illuminated manuscript produced at the Benedictine monastery of St Peder at Næstved (also called Skovkloster) ca. 1228–1250, is known for ... -
Low fibre intake is associated with gut microbiota alterations in chronic heart failure
(Journal article; Peer reviewed, 2020)Aims Recent reports have suggested that patients with heart failure (HF) have an altered gut microbiota composition; however, associations with diet remain largely uninvestigated. We aimed to explore differences in the ... -
Low heart rate variability is associated with a negativity valence bias in interpreting ambiguous emotional expressions
(Journal article; Peer reviewed, 2022)Most people tend to overstate positive aspects of their experiences, that is, a positive valence bias. However, some people tend to have attenuated attention for negative aspects of perceived information, that is, negative ... -
Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids
(Journal article; Peer reviewed, 2023)Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) ... -
Low Molecular Weight Hydrogel for Wound Healing
(Journal article; Peer reviewed, 2023)Octadecylazanediyl dipropionic acid (C18ADPA) is a zwitterionic amphiphile with a dendritic headgroup. C18ADPA self-assembles to lamellar networks, which encompasses water and forms a low-molecular-weight hydrogel (LMWG). ... -
Low myocardial energetic efficiency is associated with increased mortality in aortic stenosis
(Journal article; Peer reviewed, 2021)Objectives In hypertension, low myocardial energetic efficiency (MEEi) has been documented as an integrated marker of metabolic and left ventricular (LV) myocardial dysfunction. We tested the predictive performance of MEEi ... -
Low Persistence of Inattention Symptoms From Childhood to Adolescence: A Population-Based Study
(Journal article; Peer reviewed, 2023)Objective: To investigate the persistence of dimensional measures of inattention in a population-based, gender-balanced sample of adolescents with parent reports of inattention from childhood and self-reports of inattention ... -
Low risk pregnancies after a cesarean section: Determinants of trial of labor and its failure
(Journal article; Peer reviewed, 2020-01-13)Introduction: In pregnancies after a previous cesarean section (CS), a planned repeat CS delivery has been associated with excess risk of adverse outcome. However, also the alternative, a trial of labor after CS (TOLAC), ... -
Low serum DHEA-S is associated with impaired lung function in women
(Journal article; Peer reviewed, 2020)Background Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. ...