Now showing items 1-20 of 5233

    • A 10-gene prognostic signature points to LIMCH1 and HLA-DQB1 as important players in aggressive cervical cancer disease 

      Halle, Mari Kyllesø; Sødal, Marte; Forsse, David Erik; Engerud, Hilde Renate; Woie, Kathrine; Lura, Njål Gjærde; Wagner-Larsen, Kari Strøno; Trovik, Jone; Bertelsen, Bjørn; Haldorsen, Ingfrid S.; Ojesina, Akinyemi I.; Krakstad, Camilla (Journal article; Peer reviewed, 2021)
      Background: Advanced cervical cancer carries a particularly poor prognosis, and few treatment options exist. Identification of effective molecular markers is vital to improve the individualisation of treatment. We investigated ...
    • The 100,000–77,000‑Year Old Middle Stone Age Micromammal Sequence from Blombos Cave, South Africa: Local Climatic Stability or a Tale of Predator Bias? 

      Nel, Turid Hillestad; Henshilwood, Christopher Stuart (Journal article; Peer reviewed, 2021)
      In this paper, we present a case study of the micromammal sequence from Marine Isotope Stage 5 (130,000–71,000 YBP) at Blombos Cave on the southern Cape coast of South Africa. Our analyses of the micromammal assemblage ...
    • The 11 year solar cycle UV irradiance effect and its dependency on the Pacific Decadal Oscillation 

      Guttu, Sigmund; Orsolini, Yvan J.; Stordal, Frode; Otterå, Odd Helge; Omrani, Nour-Eddine (Journal article; Peer reviewed, 2021)
      The stratospheric, tropospheric and surface impacts from the 11 year ultraviolet solar spectral irradiance (SSI) variability have been extensively studied using climate models and observations. Here, we demonstrate using ...
    • A 115,000-year-old expedient bone technology at Lingjing, Henan, China 

      Doyon, Luc; Li, Z; Wang, H; Geis, L; d'Errico, Francesco (Journal article; Peer reviewed, 2021)
      Activities attested since at least 2.6 Myr, such as stone knapping, marrow extraction, and woodworking may have allowed early hominins to recognize the technological potential of discarded skeletal remains and equipped ...
    • A 12-month randomized controlled trial evaluating erythritol air-polishing versus curette/ultrasonic debridement of mandibular furcations in supportive periodontal therapy 

      Ulvik, Ingvild Marie; Sæthre, Terje; Bunæs, Dagmar Fosså; Lie, Stein Atle; Enersen, Morten; Leknes, Knut Norvald (Journal article; Peer reviewed, 2021)
      Background Due to complex morphology and limited access, the cleaning of the furcation area is extremely challenging. Therefore, novel therapeutic approaches need to be tested to potentially overcome debridement limitations. ...
    • 12-year trends in active school transport across four european countries—findings from the health behaviour in school-aged children (Hbsc) study 

      Haug, Ellen Merethe Melingen; Smith, Otto Robert Frans; Bucksch, Jens; Brindley, Catherina; Pavelka, Jan; Hamrik, Zdenek; Inchley, Joanna; Roberts, Chris J.; Mathisen, Frida Kathrine Sofie; Sigmundova, Dagmar (Journal article; Peer reviewed, 2021)
      Active school transport (AST) is a source of daily physical activity uptake. However, AST seems to have decreased worldwide over recent decades. We aimed to examine recent trends in AST and associations with gender, age, ...
    • 18-24-month HIV-free survival as measurement of the effectiveness of prevention of mother-to-child transmission in the context of lifelong antiretroviral therapy: Results of a community-based survey 

      Tiam, Appolinaire; Gill, Michelle; Machekano, Rhoderick; Tukei, Vincent; Mokone, Majoalane; Viana, Shannon; Letsie, Mosilinyane; Tsietso, Mots'Oane; Seipati, Irene; Khachane, Cecilia; Nei, Marethabile; Mohai, Florence; Tylleskär, Thorkild; Guay, Laura (Journal article; Peer reviewed, 2020)
      Introduction Population-based HIV-free survival at 18–24 months of age among HIV-exposed infants in high prevalence settings in the era of treatment for all is largely unknown. We conducted a community-based survey to ...
    • 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans 

      Sønderby, Ida Elken; van der Meer, Dennis; Moreau, Clara; Kaufmann, Tobias; Walters, G. Bragi; Ellegaard, Maria; Abdellaoui, Abdel; Ames, David; Amunts, Katrin; Andersson, Micael; Armstrong, Nicola J.; Bernard, Manon; Blackburn, Nicholas B.; Blangero, John; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Bülow, Robin; Bøen, Rune; Cahn, Wiepke; Calhoun, Vince D.; Caspers, Svenja; Ching, Christopher R. K.; Cichon, Sven; Ciufolini, Simone; Crespo-Facorro, Benedicto; Curran, Joanne E.; Dale, Anders M.; Dalvie, Shareefa; Dazzan, Paola; de Geus, Eco J. C.; Zubicaray, Greig I. de; Zwarte, Sonja M. C. de; Desrivieres, Sylvane; Doherty, Joanne L.; Donohoe, Gary; Draganski, Bogdan; Ehrlich, Stefan; Eising, Else; Espeseth, Thomas; Fejgin, Kim; Fisher, Simon E.; Fladby, Tormod; Frei, Oleksandr; Frouin, Vincent; Fukunaga, Masaki; Gareau, Thomas; Ge, Tian; Glahn, David C.; Grabe, Hans J.; Groenewold, Nynke A.; Gustafsson, Omar; Haavik, Jan; Haberg, Asta Kristine; Hall, Jeremy; Hashimoto, Ryota; Hehir-Kwa, Jayne Y.; Hibar, Derrek P.; Hillegers, Manon H. J.; Hoffmann, Per; Holleran, Laurena; Holmes, Avram J.; Johansson, Stefan; Jönsson, Erik Gunnar; Hellard, Stephanie Francoise Claire Le; Lundervold, Arvid; Lundervold, Astri J.; Moberget, Torgeir; Nordvik, Jan Egil; Sando, Sigrid Botne; Steen, Vidar Martin; Tamnes, Christian Krog; Agartz, Ingrid; Djurovic, Srdjan; Westlye, Lars Tjelta; Andreassen, Ole; Homuth, Georg; Hottenga, Jouke-Jan; Hulshoff Pol, Hilleke E.; Ikeda, Masashi; Jahanshad, Neda; Jockwitz, Christiane; Jørgensen, Niklas R.; Kikuchi, Masataka; Knowles, Emma E. M.; Kumar, Kuldeep; Leu, Costin; Linden, David E. J.; Liu, Jingyu; Maillard, Anne M.; Martin, Nicholas G.; Martin-Brevet, Sandra; Mather, Karen A.; Mathias, Samuel R.; McMahon, Katie L.; McRae, Allan F.; Medland, Sarah E.; Meyer-Lindenberg, Andreas; Modenato, Claudia; Monereo Sánchez, Jennifer; Morris, Derek W.; Mühleisen, Thomas W.; Murray, Robin M.; Nielsen, Jacob; Nyberg, Lars; Olde Loohuis, Loes M.; Ophoff, Roel A.; Owen, Michael J.; Paus, Tomas; Pausova, Zdenka; Peralta, Juan M.; Pike, G. Bruce; Prieto, Carlos; Quinlan, Erin B.; Reinbold, Céline S.; Reis Marques, Tiago; Rucker, James J. H.; Sachdev, Perminder S.; Schofield, Peter R.; Schork, Andrew J.; Schumann, Gunter; Shin, Jean; Shumskaya, Elena; Silva, Ana I.; Sisodiya, Sanjay M.; Stein, Dan J.; Strike, Lachlan T.; Suzuki, Ikuo K.; Teumer, Alexander; Thalamuthu, Anbupalam; Tordesillas-Gutiérrez, Diana; Uhlmann, Anne; Ulfarsson, Magnus O.; van ‘t Ent, Dennis; van den Bree, Marianne B. M.; Vanderhaeghen, Pierre; Vassos, Evangelos; Wen, Wei; Wittfeld, Katharina; Wright, Margaret J.; Stefansson, Hreinn; Stefansson, Kari; Jacquemont, Sébastien; Thompson, Paul M. (Journal article; Peer reviewed, 2021)
      Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders, including schizophrenia, autism and intellectual disability. Human carriers ...
    • A (2 + ε)-Factor Approximation Algorithm for Split Vertex Deletion 

      Lokshtanov, Daniel; Misra, Pranabendu; Panolan, Fahad; Philip, Geevarghese; Saurabh, Saket (Journal article; Peer reviewed, 2020)
      In the Split Vertex Deletion (SVD) problem, the input is an n-vertex undirected graph G and a weight function w: V(G) → ℕ, and the objective is to find a minimum weight subset S of vertices such that G-S is a split graph ...
    • 2-Deoxy-D-glucose couples mitochondrial DNA replication with mitochondrial fitness and promotes the selection of wild-type over mutant mitochondrial DNA 

      Pantic, Boris; Ives, Daniel; Mennuni, Mara; Perez-Rodriguez, Diego; Fernandez-Pelayo, Uxoa; Lopez de Arbina, Amaia; Muñoz-Oreja, Mikel; Villar-Fernandez, Marina; Dang, Thanh-mai Julie; Vergani, Lodovica; Johnston, Iain George; Pitceathly, Robert D. S.; McFarland, Robert; Hanna, Michael G.; Taylor, Robert W.; Holt, Ian J.; Spinazzola, Antonella (Journal article; Peer reviewed, 2021)
      Pathological variants of human mitochondrial DNA (mtDNA) typically co-exist with wild-type molecules, but the factors driving the selection of each are not understood. Because mitochondrial fitness does not favour the ...
    • A 2-Dose AERAS-402 Regimen Boosts CD8+ Polyfunctionality in HIV-Negative, BCG-Vaccinated Recipients 

      Sivakumaran, Dhanasekaran; Blatner, Gretta; Bakken, Rasmus; Hokey, David A.; Ritz, Christian; Jenum, Synne; Grewal, Harleen (Journal article; Peer reviewed, 2021)
      Despite the widespread use of BCG, tuberculosis (TB) remains a global threat. Existing vaccine candidates in clinical trials are designed to replace or boost BCG which does not provide satisfying long-term protection. ...
    • 2.5-fold increased risk of recurrent acute myocardial infarction with familial hypercholesterolemia 

      Svendsen, Karianne; Krogh, Henriette Walaas; Igland, Jannicke; Tell, Grethe S.; Mundal, Liv J.; Holven, Kirsten Bjørklund; Bogsrud, Martin P.; Leren, Trond P.; Retterstøl, Kjetil (Journal article; Peer reviewed, 2021)
      Background and aims A first-time acute myocardial infarction (AMI) is a severe diagnosis that leads to initiation or intensification of lipid-lowering medication to prevent recurrent events. Individuals with familial ...
    • 20 Years of Cluster Observations: The Magnetopause, 

      Håland, Stein Egil; Hasegawa, Hiroshi; Paschmann, G; Sonnerup, B. U. Ö.; Dunlop, M. W. (Journal article; Peer reviewed, 2021)
      The terrestrial magnetopause forms the boundary between the solar wind plasma with its embedded interplanetary magnetic field on one side, and the terrestrial magnetosphere, dominated by Earth's dipole field, on the other ...
    • The 2019 local and regional elections in Norway: The periphery strikes again 

      Stein, Jonas; Folkestad, Bjarte; Christensen, Dag Arne; Aars, Jacob (Journal article; Peer reviewed, 2020)
      The 2019 local and regional elections in Norway took place against the backdrop of a historical local and regional amalgamation reform initiated by the Conservative-led government in 2014. We find six key outcomes from ...
    • 2020/21 record-breaking cold waves in east of China enhanced by the ‘Warm Arctic-Cold Siberia’ pattern 

      Zhang, Yijia; Yin, Zhicong; Wang, Huijun; He, Shengping (Journal article; Peer reviewed, 2021)
      Extreme cold waves frequently occur in east of China that dramatically endanger ecological agriculture, power infrastructure and human life. In this study, we found that the 'Warm Arctic-Cold Siberia' pattern (WACS) ...
    • The 2021 FASEB science research conference on NAD metabolism and signaling 

      Gorbunova, Vera; Buschbeck, Marcus; Cambronne, Xiaolu A.; Chellappa, Karthikeyani; Corda, Daniela; Du, Juan; Freichel, Marc; Gigas, Jonathan; Green, Alexander E.; Gu, Feng; Guberovic, Iva; Jayabalan, Aravinthkumar; Khansahib, Imrankhan; Mukherjee, Sarmistha; Seluanov, Andrei; Simon, Matthew A.; Sverkeli, Lars Jansen; Kory, Nora; Levine, Daniel C.; Matic, Ivan; Nikiforov, Andrey; Rack, Johannes G.M.; Imai, Shin-Ichiro; Sinclair, David A.; Toiber, Debra; Zhao, Yongjuan; Mostoslavsky, Raul; Kraus, Lee; Guse, Andreas H. (Journal article; Peer reviewed, 2021)
    • 21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison’s Disease Are Restricted by HLA-A2 and HLA-C7 Molecules 

      Hellesen, Alexander; Aslaksen, Sigrid; Breivik, Lars Ertesvåg; Røyrvik, Ellen Christine; Bruserud, Øyvind; Edvardsen, Kine Susann Waade; Brokstad, Karl Albert; Wolff, Anette Susanne Bøe; Husebye, Eystein Sverre; Bratland, Eirik (Journal article; Peer reviewed, 2021)
      Objectives: CD8+ T cells targeting 21-hydroxylase (21OH) are presumed to play a central role in the destruction of adrenocortical cells in autoimmune Addison’s disease (AAD). Earlier reports have suggested two immunodominant ...
    • 230Th Normalization: New Insights on an Essential Tool for Quantifying Sedimentary Fluxes in the Modern and Quaternary Ocean 

      Costa, Kassandra M.; Hayes, Christopher T.; Anderson, Robert F.; Pavia, Frank J.; Bausch, Alexandra; Deng, Feifei; Dutay, Jean-Claude; Geibert, Walter; Heinze, Christoph; Henderson, Gideon M.; Hillaire-Marcel, Claude; Hoffmann, Sharon; Jaccard, Samuel L.; Jacobel, Allison W.; Kienast, Stephanie S.; Kipp, Lauren; Lerner, Paul; Lippold, Jörg; Lund, David; Marcantonio, Franco; McGee, David; McManus, Jerry F.; Mekik, Figen; Middleton, Jennifer L.; Missiaen, Lise; Not, Christelle; Pichat, Sylvain; Robinson, Laura F.; Rowland, George H.; Roy‐Barman, Matthieu; Tagliabue, Alessandro; Torfstein, Adi; Winckler, Gisela; Zhou, Yuxin (Journal article; Peer reviewed, 2020-01)
      230Th normalization is a valuable paleoceanographic tool for reconstructing high‐resolution sediment fluxes during the late Pleistocene (last ~500,000 years). As its application has expanded to ever more diverse marine ...
    • A 24,000-year ancient DNA and pollen record from the Polar Urals reveals temporal dynamics of arctic and boreal plant communities 

      Clarke, Charlotte L.; Alsos, Inger Greve; Edwards, Mary E.; Paus, Aage; Gielly, Ludovic; Haflidason, Haflidi; Mangerud, Jan; Regnéll, Carl; Hughes, Paul D.M.; Svendsen, John-Inge; Bjune, Anne Elisabeth (Journal article; Peer reviewed, 2020)
      A 24,000-year record of plant community dynamics, based on pollen and ancient DNA from the sediments (sedaDNA) of Lake Bolshoye Shchuchye in the Polar Ural Mountains, provides detailed information on the flora of the Last ...
    • 24-Month HIV-free survival among HIV-exposed Infants in Lesotho: the PEAWIL cohort study 

      Tukei, Vincent; Machekano, Rhoderick; Gill, Michelle; Tiam, Appolinaire; Mokone, Majoalane; Isavwa, Anthony; Nyabela, Malijane; Mots’oane, Tsietso; Nchephe, Seipati; Letsie, Mosilinyane; Kassaye, Seble G.; Guay, Laura (Journal article; Peer reviewed, 2020)
      Introduction Following the implementation of the provision of lifelong antiretroviral therapy to all HIV-positive pregnant or breastfeeding women for prevention of mother-to-child transmission (PMTCT) of HIV by the Kingdom ...