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Intestinal permeability and gene expression after polyethylene and polyamide microplastic ingestion in Wistar rats
(Journal article; Peer reviewed, 2022)Microplastic particles are ubiquitous in the environment. However, little is known about their uptake and effects in humans or mammalian model organisms. Here, we studied the effects of pristine polyamide (15–20 µm) and ... -
Intestinal ultrasound early on in treatment follow-up predicts endoscopic response to anti-TNFα treatment in Crohn's disease
(Journal article; Peer reviewed, 2022)Background To assess treatment response, objective measures are superior to clinical improvement in Crohn’s disease [CD]. Intestinal ultrasound [IUS] is an attractive, non-invasive alternative to endoscopy, demonstrating ... -
Intestinal Ultrasound to Assess Disease Activity in Ulcerative Colitis: Development of a novel UC-Ultrasound Index
(Journal article; Peer reviewed, 2021)Introduction: Intestinal ultrasound [IUS] is useful to assess inflammation in ulcerative colitis [UC] patients. We aimed to develop an ultrasonographic activity index using endoscopy as the reference standard. Methods: ... -
Intimate partner violence among pregnant teenagers in Lira district, northern Uganda: a cross-sectional study
(Journal article, 2020)Background/aims: Intimate partner violence during pregnancy is associated with adverse health outcomes for mothers and their unborn babies. Whereas the literature on intimate partner violence in the general population is ... -
Intimate Partner Violence and Children Under 5 Morbidities and Mortality in Afghanistan: Findings From a National Survey
(Journal article; Peer reviewed, 2023)Limited knowledge exists concerning the prevalence and drivers of intimate partner violence (IPV) against Afghan women and its association with child morbidity and mortality in Afghanistan. The study used data from the ... -
The intra-individual reliability of 1H-MRS measurement in the anterior cingulate cortex across 1 year
(Journal article; Peer reviewed, 2024)Magnetic resonance spectroscopy (MRS) is the primary method that can measure the levels of metabolites in the brain in vivo. To achieve its potential in clinical usage, the reliability of the measurement requires further ... -
Intracellular Cytidine Deaminase Regulates Gemcitabine Metabolism in Pancreatic Cancer Cell Lines
(Journal article; Peer reviewed, 2020)Cytidine deaminase (CDA) is a determinant of in vivo gemcitabine elimination kinetics and cellular toxicity. The impact of CDA activity in pancreatic ductal adenocarcinoma (PDAC) cell lines has not been elucidated. We ... -
Intracellular Energy Variability Modulates Cellular Decision-Making Capacity
(Journal article; Peer reviewed, 2019)Cells generate phenotypic diversity both during development and in response to stressful and changing environments, aiding survival. Functionally vital cell fate decisions from a range of phenotypic choices are made by ... -
Intracellular trafficking of fatty acids in the fish intestinal epithelial cell line RTgutGC
(Journal article; Peer reviewed, 2022-09-29)The shift towards higher inclusion of vegetable oils (VOs) in aquafeeds has resulted in major changes in dietary fatty acid composition, especially increased amounts of monounsaturated fatty acids (MUFAs) and decreased ... -
Intramedullary nail versus sliding hip screw for stable and unstable trochanteric and subtrochanteric fractures: 17,341 patients from the Norwegian Hip Fracture Register
(Journal article; Peer reviewed, 2022)Aims The aim of this study was to investigate if there are differences in outcome between sliding hip screws (SHSs) and intramedullary nails (IMNs) with regard to fracture stability. Methods We assessed data from ... -
Intraseasonal and synoptic modulation of diurnal surface solar radiation over Reunion island in the South-West Indian Ocean
(Journal article; Peer reviewed, 2023)Understanding the space-time variability of Surface Solar Radiation (SSR) is mandatory for the prediction and, eventually, the skillful forecasting of photovoltaic energy production. This paper addresses the modulation of ... -
Intraspecific dental variations in the deep-sea shark Etmopterus spinax and their significance in the fossil record
(Journal article; Peer reviewed, 2020)An important character on several taxonomic levels for shark identification is the tooth morphology. Sharks show a variety of highly specialized dentitions reflecting adaptations to their feeding habits. Intraspecific ... -
Intraspecific trait variability is a key feature underlying high Arctic plant community resistance to climate warming
(Journal article; Peer reviewed, 2022)In the high Arctic, plant community species composition generally responds slowly to climate warming, whereas less is known about the community functional trait responses and consequences for ecosystem functioning. The ... -
Intrauterine growth restriction and risk of diverse forms of kidney disease during the first 50 years of life
(Journal article; Peer reviewed, 2020)Background and objectives: Previous studies have shown that individuals with low birth weight (LBW) or small for gestational age (SGA) have higher risk of kidney failure. This study investigates birth-related exposures and ... -
Intrauterine growth restriction, preterm birth and risk of end-stage renal disease during the first 50 years of life
(Journal article; Peer reviewed, 2020)Background: Low birth weight (LBW) is associated with a higher risk of end-stage renal disease (ESRD). The relative impacts of absolute birth weight, birth weight in relation to gestational age and preterm birth are, ... -
Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study
(Journal article; Peer reviewed, 2020)Introduction: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disease with high symptom burden, of unknown etiology, with no established treatment. We observed patients with long-standing ME/CFS who got ... -
Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models
(Journal article; Peer reviewed, 2022)The lack of inadequate preclinical models remains a limitation for cancer drug development and is a primary contributor to anti-cancer drug failures in clinical trials. Heterotypic multicellular spheroids are three-dimensional ... -
Introducing debate as a pedagogical tool in pharmacy education
(Journal article; Peer reviewed, 2023)Communication skills are crucial for pharmacists’ role in counselling and providing information to patients, other healthcare practitioners, and the community. This study explores the implementation of debate as a pedagogical ... -
Introducing post-discharge malaria chemoprevention (PMC) for management of severe anemia in Malawian children: a qualitative study of community health workers’ perceptions and motivation
(Journal article; Peer reviewed, 2018-12-19)Severe malarial anaemia is one of the leading causes of paediatric hospital admissions in Malawi. Post-discharge malaria chemoprevention (PMC) is the intermittent administration of full treatment courses of antimalarial ... -
Introducing the index-based ecological condition assessment framework (IBECA)
(Journal article; Peer reviewed, 2021)Sustainable nature management and ecosystem conservation depends critically on scientifically sound and stakeholder-relevant analytical frameworks for monitoring and assessing ecological condition. Several general frameworks ...