Blar i Registrations from Cristin på forfatter "Langeland, Nina"
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IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria
Otterdal, Kari; Berg, Åse; Michelsen, Annika Elisabet; Yndestad, Arne; Patel, Sam; Gregersen, Ida; Halvorsen, Bente; Ueland, Thor; Langeland, Nina; Aukrust, Pål (Journal article; Peer reviewed, 2021)Background: Several inflammatory molecules participate in the immune response to malaria. Interleukin (IL)-18 is an inflammatory cytokine activated by NLRP3 inflammasomes. In clinical falciparum malaria, with and without ... -
Leishmaniasis i Norge
Muller, Karl Erik; Blomberg, Bjørn; Tellevik, Marit Gjerde; Jensenius, Mogens; Fladeby, Cathrine; Lier, Tore; Sand, Geir; Hannula, Raisa; Langeland, Nina; Mørch, Kristine (Journal article; Peer reviewed, 2021)Bakgrunn: Leishmaniasis er en sjelden, men potensielt alvorlig tropisk infeksjonssykdom. Norske klinikere er lite kjent med diagnostikk og behandling av denne sykdommen. Formålet med studien var å undersøke forekomst, ... -
Long COVID in a prospective cohort of home-isolated patients
Blomberg, Bjørn; Mohn, Kristin Greve-Isdahl; Brokstad, Karl Albert; Zhou, Fan; Linchausen, Dagrunn Waag; Hansen, Bernt-Are; Jalloh, Sarah Larteley Lartey; Onyango, Therese Bredholt; Kuwelker, Kanika; Sævik, Marianne; Bartsch, Hauke; Tøndel, Camilla; Kittang, Bård Reiakvam; Cox, Rebecca Jane; Langeland, Nina (Journal article; Peer reviewed, 2021)Long-term complications after coronavirus disease 2019 (COVID-19) are common in hospitalized patients, but the spectrum of symptoms in milder cases needs further investigation. We conducted a long-term follow-up in a ... -
Lower antibiotic prescription rates in hospitalized COVID-19 patients than influenza patients, a prospective study
Fjelltveit, Elisabeth Berg; Cox, Rebecca Jane; Kittang, Bård Reiakvam; Blomberg, Bjørn; Buanes, Eirik A.; Langeland, Nina; Mohn, Kristin Greve-Isdahl (Journal article; Peer reviewed, 2022)Background COVID-19 patients are extensively treated with antibiotics despite few bacterial complications. We aimed to study antibiotic use in hospitalized COVID-19 patients compared to influenza patients in two consecutive ... -
Malaria prevalence and performance of diagnostic tests among patients hospitalized with acute undifferentiated fever in Zanzibar
Onken, Annette; Haanshuus, Christel Gill; Miraji, Mohammed Khamis; Marijani, Msafiri; Kibwana, Kibwana Omar; Abeid, Khamis Ali; Mørch, Kristine; Reimers, Marianne; Langeland, Nina; Müller, Fredrik; Jenum, Pål; Blomberg, Bjørn (Journal article; Peer reviewed, 2022-02-19)Background: Control efforts in Zanzibar reduced the burden of malaria substantially from 2000 to 2015, but re-emergence of falciparum malaria has been observed lately. This study evaluated the prevalence of malaria and ... -
Molecular characterisation of the first New Delhi metallo-β-lactamase 1-producing Acinetobacter baumannii from Tanzania
Moyo, Sabrina John; Manyahi, Joel; Hubbard, Alasdair T. M; Byrne, Rachel L; Masoud, Nahya Salim; Aboud, Said; Manji, Karim; Blomberg, Bjørn; Langeland, Nina; Roberts, Adam P. (Journal article; Peer reviewed, 2021)Background We aimed to characterise the genetic determinants and context of two meropenem-resistant clinical isolates of Acinetobacter baumannii isolated from children hospitalised with bloodstream infections in Dar es ... -
No difference in serum levels of B-cell activating receptor and antibodies against cytolethal distending toxin B and flagellin in post-infectious irritable bowel syndrome and chronic fatigue syndrome after Giardia infection
Hanevik, Kurt; Saghaug, Christina Skår; Aaland, Maren; Mørch, Kristine; Langeland, Nina (Journal article; Peer reviewed, 2022)Background and Aim Functional gastrointestinal disorders (FGIDs) and chronic fatigue syndrome (CFS) frequently occur as comorbid conditions to each other. A shared etiology of these syndromes has been proposed because of ... -
Oocyst Shedding Dynamics in Children with Cryptosporidiosis: a Prospective Clinical Case Series in Ethiopia
Johansen, Øystein Haarklau; Abdissa, Alemseged; Bjørang, Ola; Zangenberg, Mike; Sharew, Bizuwarek; Alemu, Yonas; Moyo, Sabrina John; Mekonnen, Zeleke; Langeland, Nina; Robertson, Lucy; Hanevik, Kurt (Journal article; Peer reviewed, 2022)Knowledge on the duration of Cryptosporidium oocyst shedding, and how shedding may be affected by subtypes and clinical parameters, is limited. Reduced transmission may be a secondary benefit of cryptosporidiosis treatment ... -
Performance and operational feasibility of two diagnostic tests for cryptosporidiosis in children (CRYPTO-POC): a clinical, prospective, diagnostic accuracy study
Johansen, Øystein Haarklau; Abdissa, Alemseged; Zangenberg, Mike; Mekonnen, Zeleke; Eshetu, Beza; Bjørang, Ola; Alemu, Yonas; Sharew, Bizuwarek; Langeland, Nina; Robertson, Lucy; Hanevik, Kurt (Journal article; Peer reviewed, 2021)Background: Cryptosporidiosis is a common cause of diarrhoea in young children (aged younger than 24 months) in low-resource settings but is currently challenging to diagnose. Light-emitting diode fluorescence microscopy ... -
The Performances of Three Commercially Available Assays for the Detection of SARS‐CoV‐2 Antibodies at Different Time Points Following SARS‐CoV‐2 Infection
Syre, Heidi; Obreque, Marius Eduardo Brå; Dalen, Ingvild; Riis, Åse Garløv; Berg, Åse; Löhr, Iren Høyland; Sundal, Jon; Kleppe, Lars Kåre Selland; Vadla, May Sissel; Lenning, Ole Bernt; Olofsson, Jan Stefan; Mohn, Kristin Greve-Isdahl; Tøndel, Camilla; Blomberg, Bjørn; Trieu, Mai Chi; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2022)The aim of this study was to evaluate the performances of three commercially available antibody assays for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies at different time points ... -
Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: potential immune-regulatory role during malaria
Otterdal, Kari; Berg, Åse; Michelsen, Annika; Patel, Sam; Gregersen, Ida; Sagen, Ellen Lund; Halvorsen, Bente; Yndestad, Arne; Ueland, Thor; Langeland, Nina; Aukrust, Pål (Journal article; Peer reviewed, 2020)Background The immune response during falciparum malaria mediates both harmful and protective effects on the host; however the participating molecules have not been fully defined. Interleukin (IL)-27 is a pleiotropic ... -
Plasma parasitemia as assessed by quantitative PCR in relation to clinical disease severity in African adults with falciparum malaria with and without HIV co-infection
Berg, Åse; Patel, Sam; Tellevik, Marit Gjerde; Haanshuus, Christel Gill; Dalen, Ingvild; Otterdal, Kari; Ueland, Thor; Moyo, Sabrina John; Aukrust, Pål; Langeland, Nina (Journal article; Peer reviewed, 2020)Purpose When considering malaria disease severity, estimation of parasitemia in erythrocytes is important, but sometimes misleading, since the infected erythrocytes may be sequestered in peripheral capillaries. In African ... -
Point-of-care influenza testing impacts clinical decision, patient flow and length of stay in hospitalized adults
Fjelltveit, Elisabeth Berg; Brokstad, Rebecca Jane Cox; Østensjø, Jørgen; Blomberg, Bjørn; Ebbesen, Marit Helen; Langeland, Nina; Mohn, Kristin Greve Isdahl (Journal article; Peer reviewed, 2022)Background Influenza is difficult to distinguish clinically from other acute respiratory infections. Rapid laboratory diagnosis can help initiate early effective antiviral treatment and isolation. Implementing a novel ... -
Post COVID-19 condition after delta infection and omicron reinfection in children and adolescents
Ertesvåg, Nina Urke; Iversen, Arild; Blomberg, Bjørn; Özgümüs, Türküler; Rijal, Pramila; Fjelltveit, Elisabeth Berg; Cox, Rebecca Jane; Langeland, Nina; Haug, Kjell; Sandnes, Helene Heitmann; Mohn, Kristin Greve-Isdahl; Olofsson, Jan Stefan; Sævik, Marianne; Brokstad, Christopher James; Kuwelker, Kanika; Heienberg, Kristin (Journal article; Peer reviewed, 2023)Background: The burden of COVID-19 in children and adolescents has increased during the delta and omicron waves, necessitating studies of long-term symptoms such as fatigue, dyspnoea and cognitive problems. Furthermore, ... -
Predominance of PVL-negative community-associated methicillin-resistant Staphylococcus aureus sequence type 8 in newly diagnosed HIV-infected adults, Tanzania
Manyahi, Joel; Moyo, Sabrina John; Aboud, Said; Langeland, Nina; Blomberg, Bjørn (Journal article; Peer reviewed, 2021)Difficult-to-treat infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are of concern in people living with HIV infection as they are more vulnerable to infection. We aimed to identify molecular ... -
Presence of interferon-λ 4, male gender, absent/mild steatosis and low viral load augment antibody levels to hepatitis C virus
Waldenström, Jesper; Hellstrand, Kristoffer; Westin, Johan; Nilsson, Staffan; Christensen, Peer; Färkkilä, Martti; Mørch, Kristine; Langeland, Nina; Norkrans, Gunnar; Lagging, Martin (Journal article; Peer reviewed, 2021)Objectives Despite recombinant interferon-λ 4 (IFN-λ4) demonstrating anti-viral activity in vitro and the ancestral functional gene (IFNL4) being conserved in all other primates, there has been speculation that IFN-λ4 may ... -
Prevalence of fibromyalgia 10 years after infection with Giardia lamblia: a controlled prospective cohort study
Hunskår, Gunnhild Sellevoll; Rørtveit, Guri; Litleskare, Sverre; Eide, Geir Egil; Hanevik, Kurt; Langeland, Nina; Wensaas, Knut-Arne (Journal article; Peer reviewed, 2022)Objectives: To investigate whether acute infection with Giardia lamblia is associated with fibromyalgia 10 years after infection and whether fibromyalgia is associated with irritable bowel syndrome (IBS) and chronic fatigue ... -
A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern
Ertesvåg, Nina Urke; Xiao, Julie; Zhou, Fan; Ljostveit, Sonja; Sandnes, Helene Heitmann; Lartey, Sarah; Sævik, Marianne; Hansen, Lena; Madsen, Anders; Mohn, Kristin Greve-Isdahl; Fjelltveit, Elisabeth Berg; Olofsson, Jan Stefan; Tan, Tiong Kit; Rijal, Pramilia; Schimanski, Lisa; Øyen, Siri; Brokstad, Karl Albert; Dunachie, Susanna; Jämsén, Anni; James, William S.; Harding, Adam C.; Harvala, Heli; Nguyen, Dung; Roberts, David; Patel, Monika; Gopal, Robin; Zambon, Maria; Wei, Leiyan; Gilbert-Jaramillo, Javier; Knight, Michael L.; Vaughan-Jackson, Alun; Dupont, Maeva; Lamikanra, Abigail A.; Klennerman, Paul; Townsend, Alain; Tøndel, Camilla; Kuwelker, Kanika; Blomberg, Bjørn; Bredholt, Geir; Onyango, Therese Bredholt; Vahokoski, Juha; Bansal, Amit; Trieu, Mai Chi; Amdam, Håkon; Akselsen, Per Espen; Skorge, Trude Duelien; Okkenhaug, Liv Heiberg; Linchausen, Dagrun Waag; Langeland, Nina; Cox Brokstad, Rebecca Jane (Journal article; Peer reviewed, 2022)Background: Evaluation of susceptibility to emerging SARS-CoV-2 variants of concern (VOC) requires rapid screening tests for neutralising antibodies which provide protection. Methods: Firstly, we developed a receptor-binding ... -
The relation of 25-hydroxy vitamin D concentrations to liver histopathology, seasonality and baseline characteristics in chronic hepatitis C virus genotype 2 or 3 infection
Waldenström, Jesper; Nyström, Kristina; Nilsson, Staffan; Norkrans, Gunnar; Ydreborg, Magdalena; Langeland, Nina; Mørch, Kristine; Westin, Johan; Lagging, Martin (Journal article; Peer reviewed, 2020)Background and objectives The hydroxylation to 25-hydroxy vitamin D (25(OH)D) occurs in the liver and the impact of liver disease on vitamin D is unclear. This study evaluated the relationship between vitamin D concentrations ... -
Risk assessment and antibody responses to SARS-CoV-2 in healthcare workers
Bansal, Amit; Trieu, Mai Chi; Mohn, Kristin Greve-Isdahl; Madsen, Anders; Olofsson, Jan Stefan; Sandnes, Helene Heitmann; Sævik, Marianne; Søyland, Hanne; Hansen, Lena; Onyango, Therese Bredholt; Tøndel, Camilla; Brokstad, Karl Albert; Syre, Heidi; Riis, Åse Garløv; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2023)Background: Preventing infection in healthcare workers (HCWs) is crucial for protecting healthcare systems during the COVID-19 pandemic. Here, we investigated the seroepidemiology of SARS-CoV-2 in HCWs in Norway with ...