• Automated segmentation of endometrial cancer on MR images using deep learning 

      Hodneland, Erlend; Dybvik, Julie Andrea; Wagner-Larsen, Kari Strøno; Solteszova, Veronika; Zanna, Antonella; Fasmer, Kristine Eldevik; Krakstad, Camilla; Lundervold, Arvid; Lundervold, Alexander Selvikvåg; Salvesen, Øyvind; Erickson, Bradley J.; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2021)
      Preoperative MR imaging in endometrial cancer patients provides valuable information on local tumor extent, which routinely guides choice of surgical procedure and adjuvant therapy. Furthermore, whole-volume tumor analyses ...
    • Development of prediction models for lymph node metastasis in endometrioid endometrial carcinoma 

      Berg, Hege Fredriksen; Ju, Zhenlin; Myrvold, Madeleine; Fasmer, Kristine Eldevik; Halle, Mari Kyllesø; Høivik, Erling Andre; Westin, Shannon; Trovik, Jone; Haldorsen, Ingfrid S.; Mills, Gordon B.; Krakstad, Camilla; Werner, Henrica Maria Johanna (Journal article; Peer reviewed, 2020-02-10)
      Background In endometrioid endometrial cancer (EEC), current clinical algorithms do not accurately predict patients with lymph node metastasis (LNM), leading to both under- and over-treatment. We aimed to develop models ...
    • Diets differing in carbohydrate cellularity and amount similarly reduced visceral fat in people with obesity - a randomized controlled trial (CARBFUNC) 

      Sommersten, Cathrine Horn; Laupsa-Borge, Johnny; Andersen, Amanda Iselin Olesen; Fasmer, Kristine Eldevik; Holmefjord, Mari-Anna Frydenlund; Revheim, Ingrid; Johannessen, Kristine Kjerpeseth; Næsheim, Nicole Tandrevold; Storås, Inghild; Leikanger, Trine; Amundsen, Kristin; Skjerve, Karoline Lyngstad; Lawrence-Archer, Laurence; Spjelkavik, Camilla; Haldorsen, Ingfrid S.; Lindseth, Inge Andreas; Dierkes, Jutta; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2022)
      Background & aims: Visceral adipose tissue (VAT) volume is associated with common lifestyle diseases. Dietary quality, including food matrix and degree of carbohydrate cellularity, as well as the carbohydrate/fat ratio, ...
    • Feasibility and utility of MRI and dynamic 18F-FDG-PET in an orthotopic organoid-based patient-derived mouse model of endometrial cancer 

      Espedal, Heidi; Berg, Hege Fredriksen; Fonnes, Tina; Fasmer, Kristine Eldevik; Krakstad, Camilla; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2021)
      Background: Pelvic magnetic resonance imaging (MRI) and whole-body positron emission tomography-computed tomography (PET-CT) play an important role at primary diagnostic work-up and in detecting recurrent disease in ...
    • A gene signature identifying CIN3 regression and cervical cancer survival 

      Halle, Mari Kyllesø; Munk, Ane Cecilie Dæhli; Engesæter, Birgit Øvstebø; Akbari, Saleha; Frafjord, Astri; Høivik, Erling Andre; Forsse, David Erik; Fasmer, Kristine Eldevik; Woie, Kathrine; Haldorsen, Ingfrid S.; Bertelsen, Bjørn; Janssen, Emiel; Gudlaugsson, Einar; Krakstad, Camilla; Øvestad, Irene Tveiterås (Journal article; Peer reviewed, 2021-11-16)
      The purpose of this study was to establish a gene signature that may predict CIN3 regression and that may aid in selecting patients who may safely refrain from conization. Oncomine mRNA data including 398 immune-related ...
    • Microvascular proliferation is associated with high tumour blood flow by mpMRI and disease progression in primary prostate cancer 

      Børretzen, Astrid; Reisæter, Lars Anders Rokne; Ringheim, Anders; Gravdal, Karsten; Haukaas, Svein Andreas; Fasmer, Kristine Eldevik; Haldorsen, Ingfrid S.; Beisland, Christian; Akslen, Lars Andreas; Halvorsen, Ole Johan (Journal article; Peer reviewed, 2023)
      Active angiogenesis may be assessed by immunohistochemistry using Nestin, a marker of newly formed vessels, combined with Ki67 for proliferating cells. Here, we studied microvascular proliferation by Nestin-Ki67 co-expression ...
    • MRI-assessed tumor-free distance to serosa predicts deep myometrial invasion and poor outcome in endometrial cancer 

      Dybvik, Julie Andrea; Fasmer, Kristine Eldevik; Ytre-Hauge, Sigmund; Husby, Jenny Hild Aase; Salvesen, Øyvind; Stefansson, Ingunn Marie; Krakstad, Camilla; Trovik, Jone; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2022)
      Objectives To explore the diagnostic accuracy of preoperative magnetic resonance imaging (MRI)-derived tumor measurements for the prediction of histopathological deep (≥ 50%) myometrial invasion (pDMI) and prognostication ...
    • MRI-based radiomic signatures for pretreatment prognostication in cervical cancer 

      Wagner-Larsen, Kari Strøno; Hodneland, Erlend; Fasmer, Kristine Eldevik; Lura, Njål; Woie, Kathrine; Bertelsen, Bjørn; Salvesen, Øyvind Olav; Halle, Mari Kyllesø; Smit, Noeska Natasja; Krakstad, Camilla; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2023)
      Background Accurate pretherapeutic prognostication is important for tailoring treatment in cervical cancer (CC). Purpose To investigate whether pretreatment MRI-based radiomic signatures predict disease-specific ...
    • Near-Infrared Fluorescent Imaging for Monitoring of Treatment Response in Endometrial Carcinoma Patient-Derived Xenograft Models. 

      Fonnes, Tina; Strand, Elin; Fasmer, Kristine Eldevik; Berg, Hege Fredriksen; Espedal, Heidi; Sortland, Kristina; Stefansson, Ingunn; Bjørge, Line; Haldorsen, Ingfrid S.; Krakstad, Camilla; Mc Cormack, Emmet (Journal article; Peer reviewed, 2020)
      Imaging of clinically relevant preclinical animal models is critical to the development of personalized therapeutic strategies for endometrial carcinoma. Although orthotopic patient-derived xenografts (PDXs) reflecting ...
    • Preoperative 18F-FDG PET/CT tumor markers outperform MRI-based markers for the prediction of lymph node metastases in primary endometrial cancer 

      Fasmer, Kristine Eldevik; Gulati, Ankush; Dybvik, Julie Andrea; Ytre-Hauge, Sigmund; Salvesen, Øyvind; Trovik, Jone; Krakstad, Camilla; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2020)
      Objectives To compare the diagnostic accuracy of preoperative 18F-FDG PET/CT and MRI tumor markers for prediction of lymph node metastases (LNM) and aggressive disease in endometrial cancer (EC). Methods Preoperative ...
    • Preoperative pelvic MRI and 2-[18F]FDG PET/CT for lymph node staging and prognostication in endometrial cancer—time to revisit current imaging guidelines? 

      Fasmer, Kristine Eldevik; Gulati, Ankush; Dybvik, Julie Andrea; Wagner-Larsen, Kari Strøno; Lura, Njål Gjærde; Salvesen, Øyvind; Forsse, David Erik; Trovik, Jone; Pijnenborg, Johanna M. A.; Krakstad, Camilla; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2022)
      Objective This study presents the diagnostic performance of four different preoperative imaging workups (IWs) for prediction of lymph node metastases (LNMs) in endometrial cancer (EC): pelvic MRI alone (IW1), MRI and ...
    • A radiogenomics application for prognostic profiling of endometrial cancer 

      Høivik, Erling Andre; Hodneland, Erlend; Dybvik, Julie Andrea; Wagner-Larsen, Kari Strøno; Fasmer, Kristine Eldevik; Berg, Hege Fredriksen; Halle, Mari Kyllesø; Haldorsen, Ingfrid S.; Krakstad, Camilla (Journal article; Peer reviewed, 2021)
      Prognostication is critical for accurate diagnosis and tailored treatment in endometrial cancer (EC). We employed radiogenomics to integrate preoperative magnetic resonance imaging (MRI, n = 487 patients) with histologic-, ...
    • Visceral fat percentage for prediction of outcome in uterine cervical cancer 

      Eide, Agnes J.; Halle, Mari Kyllesø; Lura, Njål; Fasmer, Kristine Eldevik; Wagner-Larsen, Kari Strøno; Forsse, David Erik; Bertelsen, Bjørn; Salvesen, Øyvind Olav; Krakstad, Camilla; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2023)
      Objective The prognostic role of adiposity in uterine cervical cancer (CC) is largely unknown. Abdominal fat distribution may better reflect obesity than body mass index. This study aims to describe computed tomography ...
    • Whole-Volume Tumor MRI Radiomics for Prognostic Modeling in Endometrial Cancer 

      Fasmer, Kristine Eldevik; Hodneland, Erlend; Dybvik, Julie Andrea; Wagner-Larsen, Kari Strøno; Trovik, Jone; Salvesen, Øyvind; Krakstad, Camilla; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2021)
      Background In endometrial cancer (EC), preoperative pelvic MRI is recommended for local staging, while final tumor stage and grade are established by surgery and pathology. MRI‐based radiomic tumor profiling may aid in ...