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dc.contributor.authorTrpchevska, Natalia
dc.contributor.authorBulla, Jan
dc.contributor.authorPrada Hellberg, Matilda
dc.contributor.authorEdvall, Niklas K.
dc.contributor.authorLazar, Andra
dc.contributor.authorMehraei, Golbarg
dc.contributor.authorUhlen, Inger
dc.contributor.authorSchlee, Winfried
dc.contributor.authorCanlon, Barbara
dc.contributor.authorGallus, Silvano
dc.contributor.authorLopez-Escamez, Jose Antonio
dc.contributor.authorCederroth, Christopher R
dc.date.accessioned2021-02-16T11:44:06Z
dc.date.available2021-02-16T11:44:06Z
dc.date.created2020-12-02T15:34:42Z
dc.date.issued2020-11
dc.identifier.issn2077-0383
dc.identifier.urihttps://hdl.handle.net/11250/2728356
dc.description.abstractTwin and adoption studies point towards a genetic contribution to tinnitus; however, how the genetic risk applies to different forms of tinnitus is poorly understood. Here, we perform a familial aggregation study and determine the relative recurrence risk for tinnitus in siblings (λs). Four different Swedish studies (N = 186,598) were used to estimate the prevalence of self-reported bilateral, unilateral, constant, and severe tinnitus in the general population and we defined whether these 4 different forms of tinnitus segregate in families from the Swedish Tinnitus Outreach Project (STOP, N = 2305). We implemented a percentile bootstrap approach to provide accurate estimates and confidence intervals for λs. We reveal a significant λs for all types of tinnitus, the highest found being 7.27 (95% CI (5.56–9.07)) for severe tinnitus, with a higher susceptibility in women (10.25; 95% CI (7.14–13.61)) than in men (5.03; 95% CI (3.22–7.01)), suggesting that severity may be the most genetically influenced trait in tinnitus in a sex-dependent manner. Our findings strongly support the notion that genetic factors impact on the development of tinnitus, more so for severe tinnitus. These findings highlight the importance of considering tinnitus severity and sex in the design of large genetic studies to optimize diagnostic approaches and ultimately improve therapeutic interventions.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleSexual dimorphism in the familial aggregation of tinnitusen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright by the authorsen_US
dc.source.articlenumber3812en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doihttps://doi.org/10.3390/jcm9123812
dc.identifier.cristin1855456
dc.source.journalJournal of Clinical Medicineen_US
dc.source.409
dc.source.1412
dc.source.pagenumber1-10en_US
dc.source.volume9en_US
dc.source.issue12en_US


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