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dc.contributor.authorUlmner, Mattias
dc.contributor.authorSugars, Rachael
dc.contributor.authorNaimi-Akbar, Aron
dc.contributor.authorSuslu, Safiyye
dc.contributor.authorReseland, Janne Elin
dc.contributor.authorKruger-Weiner, Carina
dc.contributor.authorLund, Bodil Kristina
dc.date.accessioned2021-04-30T07:47:12Z
dc.date.available2021-04-30T07:47:12Z
dc.date.created2020-07-07T12:09:24Z
dc.date.issued2020
dc.PublishedJournal of Oral Rehabilitation. 2020, 47 (10), 1202-1211.
dc.identifier.issn0305-182X
dc.identifier.urihttps://hdl.handle.net/11250/2740480
dc.description.abstractBackground Symptomatic disc displacement (DD) of the temporomandibular joint (TMJ) may cause pain and limited mouth opening. The aetiopathogenesis is obscure and probably complex, which makes the diagnostic classification crude and mainly based on clinical criteria rather than disease mechanisms, and tissue characteristics. Objectives The study aim was to characterise and quantify synovial tissue in DD, where specific cytokine patterns might serve as potential biomarkers. Methods An observational cohort study was performed harvesting synovial tissue from 63 patients: 44 with DD without reduction (DDwoR) and 19 with DD with reduction (DDwR). DDwoR was subdivided depending on type of onset (sudden, n = 17; delayed, n = 27), and DDwR served as the control group. Proteins were extracted from tissue samples and investigated in a multi‐analytic profiling system. Results DDwoR patients had significantly higher concentrations in 12 out of 28 analysed cytokines compared to DDwR. In the same statistical model, significantly lower concentrations of interferon gamma‐induced protein (IP) 10, osteoprotegerin (OPG) and RANTES were detected in DDwoR patients. Women showed significantly higher concentrations of epidermal growth factor and interleukin (IL) 1ra compared to men. DDwoR with sudden onset had significant higher concentrations of bone morphogenetic protein 4, eotaxin and IL‐8 compared to DDwoR with delayed onset. Conclusions Characterising the biomarker panel for TMJ conditions may serve as suggestible targets for disease classification and novel treatment options. The significantly lower concentrations of IP‐10, OPG and RANTES could be proposed as putative markers for the separation of the studied conditions to other TMJ diseases.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleSynovial tissue cytokine profile in disc displacement of the temporomandibular jointen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2020 The Authorsen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1111/joor.13051
dc.identifier.cristin1818815
dc.source.journalJournal of Oral Rehabilitationen_US
dc.source.4047
dc.source.1410
dc.source.pagenumber1202-1211en_US
dc.identifier.citationJournal of Oral Rehabilitation. 2020, 47 (10), 1202-1211.en_US
dc.source.volume47en_US
dc.source.issue10en_US


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal