Show simple item record

dc.contributor.authorRogne, Ane Gretesdatter
dc.contributor.authorMüller, Ebba Gløersen
dc.contributor.authorUdnæs, Eirin
dc.contributor.authorSigurdardottir, Solrun
dc.contributor.authorRaudeberg, Rune
dc.contributor.authorConnelly, James Pattrick
dc.contributor.authorRevheim, Mona-Elisabeth
dc.contributor.authorHassel, Bjørnar
dc.contributor.authorDahlberg, Daniel
dc.date.accessioned2021-04-30T08:31:24Z
dc.date.available2021-04-30T08:31:24Z
dc.date.created2020-11-17T08:31:59Z
dc.date.issued2021
dc.identifier.issn1351-5101
dc.identifier.urihttps://hdl.handle.net/11250/2740503
dc.descriptionUnder embargo until: 2021-10-31en_US
dc.description.abstractBackground and purpose β‐Amyloid formation has been suggested to form part of the brain's response to bacterial infection. This hypothesis has been based on experimental animal studies and autopsy studies in humans. We asked if β‐amyloid accumulates locally around a bacterial brain abscess in living human patients. Furthermore, because brain abscess patients may suffer from chronic cognitive symptoms after abscess treatment, we also asked if a brain abscess precipitates accumulation of β‐amyloid in the neocortex in a manner that could explain abscess‐related cognitive complaints. Methods In a prospective study, we investigated 17 brain abscess patients (age 24–72 years) with 18F‐flutemetamol positron emission tomography on one occasion 1 to 10 months after brain abscess treatment to visualize β‐amyloid accumulation. Results 18F‐flutemetamol uptake was reduced in the edematous brain tissue that surrounded the abscess remains. On this background of reduced 18F‐flutemetamol signal, three out of 17 patients showed a distinctly increased 18F‐flutemetamol uptake in the tissue immediately surrounding the abscess remains, suggesting accumulation of β‐amyloid. These three patients underwent 18F‐flutemetamol positron emission tomography significantly earlier after neurosurgical treatment (p = 0.042), and they had larger abscesses (p = 0.027) than the rest of the patients. All 17 patients suffered from mental fatigue or some subjective cognitive symptom, such as attention difficulties or memory problems, but in none of the patients was there an increase in neocortical 18F‐flutemetamol signal. Conclusions β‐Amyloid may accumulate locally around the abscess remains in some patients with a brain abscess.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.titleβ-Amyloid may accumulate in the human brain after focal bacterial infection: a 18F-flutemetamol positron emission tomography studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionacceptedVersionen_US
dc.rights.holderCopyright 2020 European Academy of Neurologyen_US
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2
dc.identifier.doihttps://doi.org/10.1111/ene.14622
dc.identifier.cristin1848613
dc.source.journalEuropean Journal of Neurologyen_US
dc.source.pagenumber877-883en_US
dc.identifier.citationEuropean Journal of Neurology. 2021, 28(3):877-883en_US
dc.source.volume28en_US
dc.source.issue3en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record