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dc.contributor.authorAlvarez, Carla
dc.contributor.authorAbdalla, Henrique
dc.contributor.authorSuliman, Salwa
dc.contributor.authorRojas, Paola
dc.contributor.authorWu, Yu-Chiao
dc.contributor.authorAlmarhoumi, Rawan
dc.contributor.authorHuang, Ren-Yeong
dc.contributor.authorGalindo, Mario
dc.contributor.authorVernal, Rolando
dc.contributor.authorKantarci, Alpdogan
dc.description.abstractPeriodontitis is a chronic inflammatory disease associated with the formation of dysbiotic plaque biofilms and characterized by the progressive destruction of the alveolar bone. The transition from health to disease is characterized by a shift in periodontal immune cell composition, from mostly innate (neutrophils) to adaptive (T lymphocytes) immune responses. Resolvin E1 (RvE1) is a specialized pro-resolution mediator (SPMs), produced in response to inflammation, to enhance its resolution. Previous studies have indicated the therapeutic potential of RvE1 in periodontal disease; however, the impact of RvE1 in the microbial-elicited osteoclastogenic immune response remains uncharacterized in vivo. In the present study, we studied the impact of RvE1 on the gingival inflammatory infiltrate formation during periodontitis in a mouse model. First, we characterized the temporal-dependent changes of the main immune cells infiltrating the gingiva by flow cytometry. Then, we evaluated the impact of early or delayed RvE1 administration on the gingival immune infiltration and cervical lymph nodes composition. We observed a consistent inhibitory outcome on T cells -particularly effector T cells- and a protective effect on regulatory T cells (Tregs). Our data further demonstrated the wide range of actions of RvE1, its preventive role in the establishment of the adaptive immune response during inflammation, and bone protective capacity.en_US
dc.publisherFrontiers Mediaen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleRvE1 Impacts the Gingival Inflammatory Infiltrate by Inhibiting the T Cell Response in Experimental Periodontitisen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2021 Alvarez, Abdalla, Sulliman, Rojas, Wu, Almarhoumi, Huang, Galindo, Vernal and Kantarcien_US
dc.source.journalFrontiers in Immunologyen_US
dc.identifier.citationFrontiers in Immunology. 2021, 12, 664756.en_US

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