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dc.contributor.authorSinitcyn, Pavel
dc.contributor.authorHamzeiy, Hamid
dc.contributor.authorSalinas Soto, Favio
dc.contributor.authorItzhak, Daniel
dc.contributor.authorMcCarthy, Frank
dc.contributor.authorWichmann, Christoph
dc.contributor.authorSteger, Martin
dc.contributor.authorOhmayer, Uli
dc.contributor.authorDistler, Ute
dc.contributor.authorKaspar-Schoenefeld, Stephanie
dc.contributor.authorPrianichnikov, Nikita
dc.contributor.authorYılmaz, Şule
dc.contributor.authorRudolph, Jan Daniel
dc.contributor.authorTenzer, Stefan
dc.contributor.authorPerez-Riverol, Yasset
dc.contributor.authorNagaraj, Nagarjuna
dc.contributor.authorHumphrey, Sean J.
dc.contributor.authorCox, Juergen
dc.date.accessioned2022-04-01T08:19:43Z
dc.date.available2022-04-01T08:19:43Z
dc.date.created2022-01-28T12:39:05Z
dc.date.issued2021
dc.identifier.issn1087-0156
dc.identifier.urihttps://hdl.handle.net/11250/2989094
dc.description.abstractMaxDIA is a software platform for analyzing data-independent acquisition (DIA) proteomics data within the MaxQuant software environment. Using spectral libraries, MaxDIA achieves deep proteome coverage with substantially better coefficients of variation in protein quantification than other software. MaxDIA is equipped with accurate false discovery rate (FDR) estimates on both library-to-DIA match and protein levels, including when using whole-proteome predicted spectral libraries. This is the foundation of discovery DIA—hypothesis-free analysis of DIA samples without library and with reliable FDR control. MaxDIA performs three- or four-dimensional feature detection of fragment data, and scoring of matches is augmented by machine learning on the features of an identification. MaxDIA’s bootstrap DIA workflow performs multiple rounds of matching with increasing quality of recalibration and stringency of matching to the library. Combining MaxDIA with two new technologies—BoxCar acquisition and trapped ion mobility spectrometry—both lead to deep and accurate proteome quantification.en_US
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleMaxDIA enables library-based and library-free data-independent acquisition proteomicsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright The Author(s) 2021en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1038/s41587-021-00968-7
dc.identifier.cristin1992315
dc.source.journalNature Biotechnologyen_US
dc.source.pagenumber1563-1573en_US
dc.identifier.citationNature Biotechnology. 2021, 39, 1563-1573.en_US
dc.source.volume39en_US


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