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dc.contributor.authorHaugland, Gyri Teien
dc.contributor.authorRønneseth, Anita
dc.contributor.authorGundersen, Lene
dc.contributor.authorLunde, Harald Sæbø
dc.contributor.authorNordland, Kaja
dc.contributor.authorWergeland, Heidrun Inger
dc.date.accessioned2022-11-18T12:44:12Z
dc.date.available2022-11-18T12:44:12Z
dc.date.created2022-11-07T12:22:56Z
dc.date.issued2022
dc.identifier.issn2468-550X
dc.identifier.urihttps://hdl.handle.net/11250/3032883
dc.description.abstractAntigen-presentation via major histocompatibility complex (MHC) to T cells is the key event to initiate adaptive immune responses. In teleosts, as in mammals, the main types of professional antigen-presenting cells (APCs) are dendritic cells (DCs), monocytes/macrophages, and B cells. In the current study, flow cytometry, immunostaining and qPCR have been used to show that neutrophils in the teleost fish Atlantic salmon (Salmo salar L.) have antigen-presenting properties. The neutrophils were positive for MHC class II, CD83 and CD80/86, and upon in vitro bacterial exposure, gene expression analysis of purified neutrophils showed that IL-12p40, which is essential for proliferation of naïve T cells, was highly upregulated at both 6 and 24 h post bacterial exposure. Based on presence of MHC class II and upregulation of molecules involved in antigen presentation and T cell activation, we suggest that neutrophils in Atlantic salmon have potential to function as professional APCs. This work makes an important basis for further exploring the potential of using neutrophils to develop new, targeted immunoprophylactic measures.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleNeutrophils in Atlantic salmon (Salmo salar L.) are MHC class II+ and secret IL-12p40 upon bacterial exposureen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 Shanghai Ocean Universityen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1016/j.aaf.2022.07.002
dc.identifier.cristin2069916
dc.source.journalAquaculture and Fisheriesen_US
dc.identifier.citationAquaculture and Fisheries. 2022.en_US


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal