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dc.contributor.authorMarquardt, Lynn Anne
dc.contributor.authorCraven, Alexander R.
dc.contributor.authorHugdahl, Kenneth Jan
dc.contributor.authorJohnsen, Erik
dc.contributor.authorKroken, Rune Andreas
dc.contributor.authorKusztrits, Isabella
dc.contributor.authorSpecht, Karsten
dc.contributor.authorThomassen, Anne Synnøve
dc.contributor.authorWeber, Sarah
dc.contributor.authorHirnstein, Marco
dc.description.abstractBackground: Transcranial direct current stimulation (tDCS) is used as treatment for auditory verbal hallucinations (AVH). The theory behind the treatment is that tDCS increases activity in prefrontal cognitive control areas, which are assumed to be hypoactive, and simultaneously decreases activity in temporal speech perception areas, which are assumed to be hyperactive during AVH. We tested this hypofrontal/hypertemporal reversal theory by investigating anatomical, neurotransmitter, brain activity, and network connectivity changes over the course of tDCS treatment. Methods: A double-blind, randomized controlled trial was conducted with 21 patients receiving either sham or real tDCS treatment (2 mA) twice daily for 5 days. The anode was placed over the left dorsolateral prefrontal cortex (DLPFC) and the cathode over the left temporo-parietal cortex (TPC). Multimodal neuroimaging as well as clinical and neurocognitive functioning assessment were performed before, immediately after, and three months after treatment. Results: We found a small reduction in AVH severity in the real tDCS group, but no corresponding neuroimaging changes in either DLPFCD or TPC. Limitations: The study has a small sample size. Conclusion: The results suggest that the currently leading theory behind tDCS treatment of AVH may need to be revised, if confirmed by studies with larger N. Tentative findings point to the involvement of Broca’s area as a critical structure for tDCS treatment.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titlePilot-RCT Finds No Evidence for Modulation of Neuronal Networks of Auditory Hallucinations by Transcranial Direct Current Stimulationen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2022 the authorsen_US
dc.source.journalBrain Sciencesen_US
dc.identifier.citationBrain Sciences. 2022, 12 (10), 1382.en_US

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Navngivelse 4.0 Internasjonal
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