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dc.contributor.authorEtayo, Angela
dc.contributor.authorLie, Kai Kristoffer
dc.contributor.authorBjelland, Reidun Marie
dc.contributor.authorHordvik, Ivar
dc.contributor.authorØvergård, Aina-Cathrine
dc.contributor.authorSæle, Øystein
dc.date.accessioned2023-08-10T06:56:24Z
dc.date.available2023-08-10T06:56:24Z
dc.date.created2023-06-14T09:44:11Z
dc.date.issued2023-05-01
dc.identifier.issn1664-3224
dc.identifier.urihttps://hdl.handle.net/11250/3083266
dc.description.abstractMarine fish larvae often experience high mortality unrelated to predation during early life stages, and farmed ballan wrasse (Labrus bergylta) is no exception. Knowing when the adaptive immune system is developed and fully functional, and how nutrition may modulate these processes is therefore of importance to establish effective prophylactic measures and will also extend the relatively limited knowledge on the immune system in lower vertebrates. The thymus anlage of ballan wrasse was found to be histologically visible for the first time at larval stage 3 (20–30 days post hatch, dph) and becomes lymphoid at stage 5 (50–60 dph) correlating with an increase of T-cell marker transcripts. At this stage, a clear zonation into a RAG1+ cortex and a RAG1- CD3ϵ+ medulla was distinguished, indicating that T-cell maturation processes in ballan wrasse are similar to other teleosts. The higher abundance of CD4-1+ compared to CD8β+ cells in the thymus together with the apparent lack of CD8β+ cells in gill, gut, and pharynx, where CD4-1+ cells were identified, indicates that helper T-cells have a more prominent role during larval development compared to cytotoxic T-cells. As ballan wrasse lacks a stomach but has an exceptionally high IgM expression in the hindgut, we hypothesize that helper T-cells are crucial for activation and recruitment of IgM+ B-cells and possibly other leukocytes to the gut during early development. Nutritional factors such as DHA/EPA, Zn and Se may lead to an earlier expression of certain T-cell markers as well as a larger size of the thymus, indicating an earlier onset of adaptive immunity. Including live feeds that supplies the larva with higher amounts of these nutrients can therefore be beneficial for ballan wrasse farming.en_US
dc.language.isoengen_US
dc.publisherFrontiersen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleThe thymus and T-cell ontogeny in ballan wrasse (Labrus bergylta) is nutritionally modelleden_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2023 the authorsen_US
dc.source.articlenumber1166785en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.3389/fimmu.2023.1166785
dc.identifier.cristin2154331
dc.source.journalFrontiers in Immunologyen_US
dc.identifier.citationFrontiers in Immunology. 2023, 14, 1166785.en_US
dc.source.volume14en_US


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