dc.contributor.author | Jensen, Synnøve Stokke | |
dc.contributor.author | Austin, Christine | |
dc.contributor.author | Arora, Manish | |
dc.contributor.author | Lie, Stein Atle | |
dc.contributor.author | Øilo, Marit | |
dc.contributor.author | Klock, Kristin S. | |
dc.date.accessioned | 2023-10-10T12:32:08Z | |
dc.date.available | 2023-10-10T12:32:08Z | |
dc.date.created | 2023-09-28T09:43:34Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 2666-7657 | |
dc.identifier.uri | https://hdl.handle.net/11250/3095521 | |
dc.description.abstract | The Norwegian Mother, Father and Child Cohort Study (MoBa) includes a nation-wide collection of deciduous teeth located in the MoBaTooth biobank. The aim of the present study is to create a baseline for early-life metal exposure using dentine biomarkers.
Deciduous teeth were collected in the MoBaTooth biobank, a sub-study of the MoBa-study. This study uses 94 primary teeth from children with no known medical conditions at the age of 6 months, a normal birth weight (2500-4500g) and an equal number of teeth shed between 2008-2013 and 2014-2019. A total of 48 girls and 46 boys are included to create a baseline to characterise retrospective exposure to toxicants during multiple early-life developmental periods. Estimates of weekly prenatal and postnatal exposure to 18 metals by measuring dentine concentrations have been made using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS).
Temporal trends in dentine levels differed from metal to metal. Girls had higher postnatal dentine levels of Mn and Zn, compared to boys (p = 0.020 for postnatal Mn-levels, and p = 0.011 for postnatal Zn-levels).
Deciduous teeth provide retrospective information on the intensity and timing of early-life metal exposure at weekly temporal resolution. Creating a baseline, future studies can use outcomes of conditions and illness in children in case-control-studies aiming at prevention. Using deciduous teeth, a novel noninvasive biomarker, characterising early-life exposure to 18 metals in approximately weekly increments during sensitive developmental periods extending from the second trimester to 4 months postnatally has been performed. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Toxic and essential trace elements in human primary teeth: A baseline study within The MoBaTooth Biobank and The Norwegian Mother, Father and Child Cohort Study (MoBa) | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2023 The Author(s) | en_US |
dc.source.articlenumber | 100418 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1016/j.envadv.2023.100418 | |
dc.identifier.cristin | 2179713 | |
dc.source.journal | Environmental Advances | en_US |
dc.identifier.citation | Environmental Advances. 2023, 13, 100418. | en_US |
dc.source.volume | 13 | en_US |