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Molecular evidence for a single origin of ultrafiltration-based excretory organs
(Journal article; Peer reviewed, 2021)Excretion is an essential physiological process, carried out by all living organisms, regardless of their size or complexity.1, 2, 3 Both protostomes (e.g., flies and flatworms) and deuterostomes (e.g., humans and sea ... -
Extreme Levels of Ocean Acidification Restructure the Plankton Community and Biogeochemistry of a Temperate Coastal Ecosystem: A Mesocosm Study
(Journal article; Peer reviewed, 2021)The oceans’ uptake of anthropogenic carbon dioxide (CO2) decreases seawater pH and alters the inorganic carbon speciation – summarized in the term ocean acidification (OA). Already today, coastal regions experience episodic ... -
Comparative Animal Mucomics: Inspiration for Functional Materials from Ubiquitous and Understudied Biopolymers
(Journal article; Peer reviewed, 2020)The functions of secreted animal mucuses are remarkably diverse and include lubricants, wet adhesives, protective barriers, and mineralizing agents. Although present in all animals, many open questions related to the ... -
Oikopleura
(Journal article; Peer reviewed, 2020) -
Characterization of Schistosoma mansoni Glutamate-Gated Chloride Channels
(Journal article; Peer reviewed, 2020)Electrophysiology is the standard method for characterizing ion channel function. Two-electrode voltage clamp is a robust and relatively simple version which can be applied to the characterization of glutamate-gated chloride ... -
Functional annotation of human long noncoding RNAs via molecular phenotyping
(Journal article; Peer reviewed, 2020)Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression ... -
Conservative route to genome compaction in a miniature annelid
(Journal article; Peer reviewed, 2021)The causes and consequences of genome reduction in animals are unclear because our understanding of this process mostly relies on lineages with often exceptionally high rates of evolution. Here, we decode the compact ... -
Toxin-like neuropeptides in the sea anemone Nematostella unravel recruitment from the nervous system to venom
(Journal article; Peer reviewed, 2020)The sea anemone Nematostella vectensis (Anthozoa, Cnidaria) is a powerful model for characterizing the evolution of genes functioning in venom and nervous systems. Although venom has evolved independently numerous times ... -
Widespread conservation and lineage-specific diversification of genome-wide DNA methylation patterns across arthropods
(Journal article; Peer reviewed, 2020)Cytosine methylation is an ancient epigenetic modification yet its function and extent within genomes is highly variable across eukaryotes. In mammals, methylation controls transposable elements and regulates the promoters ... -
Peptide Inhibitors of the α‑Cobratoxin−Nicotinic Acetylcholine Receptor Interaction
(Journal article; Peer reviewed, 2020)Venomous snakebites cause >100 000 deaths every year, in many cases via potent depression of human neuromuscular signaling by snake α-neurotoxins. Emergency therapy still relies on antibody-based antivenom, hampered by ... -
RAB5A and TRAPPC6B are novel targets for Shiga toxin 2a inactivation in kidney epithelial cells
(Journal article; Peer reviewed, 2020-03-18)The cardinal virulence factor of human-pathogenic enterohaemorrhagic Escherichia coli (EHEC) is Shiga toxin (Stx), which causes severe extraintestinal complications including kidney failure by damaging renal endothelial ... -
NvPOU4/Brain3 Functions as a Terminal Selector Gene in the Nervous System of the Cnidarian Nematostella vectensis
(Journal article; Peer reviewed, 2020-03)Terminal selectors are transcription factors that control the morphological, physiological, and molecular features that characterize distinct cell types. Here, we show that, in the sea anemone Nematostella vectensis, NvPOU4 ... -
RADICL-seq identifies general and cell type–specific principles of genome-wide RNA-chromatin interactions
(Journal article; Peer reviewed, 2020)Mammalian genomes encode tens of thousands of noncoding RNAs. Most noncoding transcripts exhibit nuclear localization and several have been shown to play a role in the regulation of gene expression and chromatin remodeling. ... -
The visual pigment xenopsin is widespread in protostome eyes and impacts the view on eye evolution
(Journal article; Peer reviewed, 2020)Photoreceptor cells in the eyes of Bilateria are often classified into microvillar cells with rhabdomeric opsin and ciliary cells with ciliary opsin, each type having specialized molecular components and physiology. First ... -
The development of early pioneer neurons in the annelid Malacoceros fuliginosus
(Journal article; Peer reviewed, 2020)Background Nervous system development is an interplay of many processes: the formation of individual neurons, which depends on whole-body and local patterning processes, and the coordinated growth of neurites and synapse ... -
Generating transgenic reporter lines for studying nervous system development in the cnidarian nematostella vectensis
(Journal article; Peer reviewed, 2020)Neurons often display complex morphologies with long and fine processes that can be difficult to visualize, in particular in living animals. Transgenic reporter lines in which fluorescent proteins are expressed in defined ... -
The genetic basis for PRC1 complex diversity emerged early in animal evolution
(Journal article; Peer reviewed, 2020)Polycomb group proteins are essential regulators of developmental processes across animals. Despite their importance, studies on Polycomb are often restricted to classical model systems and, as such, little is known about ... -
Some like it hot: population-specific adaptations in venom production to abiotic stressors in a widely distributed cnidarian
(Journal article; Peer reviewed, 2020-09)Background: In cnidarians, antagonistic interactions with predators and prey are mediated by their venom, whose synthesis may be metabolically expensive. The potentially high cost of venom production has been hypothesized ... -
Institution of Sponsorship from Ancient to Modern Times
(Book, 2019) -
Diversity and host associations of Myrsidea chewing lice (Phthiraptera: Menoponidae) in the tropical rainforest of Malaysian Borneo
(Journal article; Peer reviewed, 2020)The tropical rainforests of Sundaland are a global biodiversity hotspot increasingly threatened by human activities. While parasitic insects are an important component of the ecosystem, their diversity and parasite-host ...
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