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dc.contributor.authorChen, Yingen_US
dc.contributor.authorKlingen, Tor Audunen_US
dc.contributor.authorWik, Elisabethen_US
dc.contributor.authorAas, Hansen_US
dc.contributor.authorVigeland, Einaren_US
dc.contributor.authorLiestøl, Knuten_US
dc.contributor.authorGarred, Øysteinen_US
dc.contributor.authorMæhlen, Janen_US
dc.contributor.authorAkslen, Lars A.en_US
dc.contributor.authorLømo, Jonen_US
dc.description.abstractBackground: Mammography screen-detected breast cancers have a better prognosis than predicted from established prognostic markers. A search for additional features that are characteristic for these tumours and their prognosis is needed to reduce overtreatment, a recognized challenge in breast cancer patient management today. Here, we have investigated the occurrence and importance of tumour elastosis. Methods: We performed a population based retrospective study of breast cancers detected in the Norwegian Breast Cancer Screening Programme in Vestfold County during 2004–2009. In total, 197 invasive screen-detected cancers and 75 interval cancers in patients aged 50–69 years were compared with regard to standard clinico-pathological parameters and tumour shape, as well as ER, PR, HER2 and Ki67 expression. In particular, the presence of elastotic material in tumours was graded on a 4-tiered scale (score 0–3). Results: Screen-detected cancers had a significantly higher content of stromal elastosis than interval cancers (p < 0.001). High content of elastosis (score 3) correlated strongly with stellate tumour shape, low histological grade, and ER+/HER2- status. Further, high elastosis score was significantly associated with lower Ki67 expression. In survival analyses, cases with high elastosis demonstrated increased recurrence free (p = 0.03) and disease-specific survival (p = 0.11) compared to cases with low elastosis. Conclusion: There is a strong correlation between the presence of tumour elastosis, stellate tumour shape and mammography detection of breast cancers. To our knowledge, this is the first time elastosis has been studied in relation to breast cancer detection method. Presence of elastosis is associated with low tumour cell proliferation (Ki67) and a good prognosis.en_US
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.subjectBreast cancereng
dc.subjectMammography screeningeng
dc.titleBreast cancer stromal elastosis is associated with mammography screening detection, low Ki67 expression and favourable prognosis in a population-based studyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2014 Chen et al.; licensee BioMed Central
dc.source.journalDiagnostic Pathology

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