Vis enkel innførsel

dc.contributor.authorEl-Salhy, Magdyen_US
dc.contributor.authorGilja, Odd Helgeen_US
dc.contributor.authorHatlebakk, Jan Gen_US
dc.contributor.authorHausken, Trygveen_US
dc.date.accessioned2015-09-08T13:15:54Z
dc.date.available2015-09-08T13:15:54Z
dc.date.issued2014-10
dc.identifier.issn1107-3756
dc.identifier.urihttps://hdl.handle.net/1956/10438
dc.description.abstractTo the best of our knowledge, stomach antral endocrine cells have not previously been investigated in patients with irritable bowel syndrome (IBS). Thus, in the present study, 76 patients with IBS were examined (designated as IBS-total). Diarrhoea was the predominant symptom in 26 of these patients (IBS-D), while in 21 patients, the predominant symptoms were both diarrhoea and constipation (IBS-M) and in 29 patients the predominant symptom was constipation (IBS-C). Forty-three healthy subjects were enrolled as the controls. Stomach antral biopsy samples obtained from all of the subjects were immunostained using the avidin-biotin-complex method for serotonin, gastrin, somatostatin and serotonin transporter (SERT). The immunopositive cell densities and immunoreactivity intensities were determined by computer-aided image analysis. The density of the serotonin-immunoreactive cells was significantly decreased in the IBS-M patients and increased in the IBS-C patients relative to the controls. The immunoreactivity intensity did not differ significantly between the controls and IBS-total. The density of the gastrin-immunoreactive cells was significantly greater in the IBS-D, IBS-M and IBS-C patients than in the controls. The immunoreactivity intensity of gastrin was significantly greater in the IBS-D patients than in the controls. The density of the somatostatin-immunoreactive cells cells was significantly lower in the IBS-total, IBS-D, IBS-M and IBS-C patients than in the controls. The immunoreactivity intensities of both somatostatin and SERT did not differ significantly between the controls and IBS-total. The increase in gastrin cell density and the decrease in somatostatin cell density in all IBS subtypes may cause high levels of gastric secretion, which may in turn contribute to the high incidence of dyspepsia and gastro-oesophageal reflux observed in patients with IBS.en_US
dc.language.isoengeng
dc.publisherSpandidoseng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.subjectcomputer-aided image analysiseng
dc.subjectgastrineng
dc.subjectimmunohistochemistryeng
dc.subjectserotonineng
dc.subjectsomatostatineng
dc.titleStomach antral endocrine cells in patients with irritable bowel syndromeen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-07-29T13:20:13Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2014 The Authors
dc.identifier.doihttps://doi.org/10.3892/ijmm.2014.1887
dc.identifier.cristin1156070
dc.source.journalInternational Journal of Molecular Medicine
dc.source.4034
dc.source.144
dc.source.pagenumber967-974
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Gasteroenterologi: 773
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Gastroenterology: 773


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Attribution CC BY
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution CC BY