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dc.contributor.authorAmaral, André F.S.en_US
dc.contributor.authorRamasamy, Adaikalavanen_US
dc.contributor.authorCastro-Giner, Francescen_US
dc.contributor.authorMinelli, Cosettaen_US
dc.contributor.authorAccordini, Simoneen_US
dc.contributor.authorSørheim, Inga Cecilieen_US
dc.contributor.authorPin, Isabelleen_US
dc.contributor.authorKogevinas, Manolisen_US
dc.contributor.authorJõgi, Rainen_US
dc.contributor.authorBalding, David J.en_US
dc.contributor.authorNorbäck, Danen_US
dc.contributor.authorVerlato, Guiseppeen_US
dc.contributor.authorOlivieri, Marioen_US
dc.contributor.authorProbst-Hensch, Nicoleen_US
dc.contributor.authorJanson, Christeren_US
dc.contributor.authorZock, Jan-Paulen_US
dc.contributor.authorHeinrich, Joachimen_US
dc.contributor.authorJarvis, Deborah L.en_US
dc.description.abstractBackground: Increased bronchial responsiveness is characteristic of asthma. Gas cooking, which is a major indoor source of the highly oxidant nitrogen dioxide, has been associated with respiratory symptoms and reduced lung function. However, little is known about the effect of gas cooking on bronchial responsiveness and on how this relationship may be modified by variants in the genes GSTM1, GSTT1 and GSTP1, which influence antioxidant defences. Methods: The study was performed in subjects with forced expiratory volume in one second at least 70% of predicted who took part in the multicentre European Community Respiratory Health Survey, had bronchial responsiveness assessed by methacholine challenge and had been genotyped for GSTM1, GSTT1 and GSTP1-rs1695. Information on the use of gas for cooking was obtained from interviewer-led questionnaires. Effect modification by genotype on the association between the use of gas for cooking and bronchial responsiveness was assessed within each participating country, and estimates combined using meta-analysis. Results: Overall, gas cooking, as compared with cooking with electricity, was not associated with bronchial responsiveness (β=−0.08, 95% CI −0.40 to 0.25, p=0.648). However, GSTM1 significantly modified this effect (β for interaction=−0.75, 95% CI −1.16 to −0.33, p=4×10⁻⁴) , with GSTM1 null subjects showing more responsiveness if they cooked with gas. No effect modification by GSTT1 or GSTP1-rs1695 genotypes was observed. Conclusions: Increased bronchial responsiveness was associated with gas cooking among subjects with the GSTM1 null genotype. This may reflect the oxidant effects on the bronchi of exposure to nitrogen dioxide.en_US
dc.rightsAttribution CC BYeng
dc.titleInteraction between gas cooking and GSTM1 null genotype in bronchial responsiveness: Results from the European Community Respiratory Health Surveyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2014 The Authors
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Lungesykdommer: 777
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Lung diseases: 777

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