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dc.contributor.authorMoyo, Sabrina Johnen_US
dc.contributor.authorHanevik, Kurten_US
dc.contributor.authorBlomberg, Bjørnen_US
dc.contributor.authorKommedal, Øyvinden_US
dc.contributor.authorNordbø, Svein Arneen_US
dc.contributor.authorMaselle, Samuel Yen_US
dc.contributor.authorLangeland, Ninaen_US
dc.date.accessioned2015-09-29T13:24:59Z
dc.date.available2015-09-29T13:24:59Z
dc.date.issued2014-12-12
dc.PublishedBMC Infectious Diseases 2014, 14:666eng
dc.identifier.issn1471-2334
dc.identifier.urihttps://hdl.handle.net/1956/10536
dc.description.abstractBackground: Human adenovirus (HAdV) causes acute diarrhoea sporadically, as well as in outbreaks. Understanding the prevalence and types of HAdV in diarrhoea is important for control and preventive measures, especially in the African region where there is a high burden of diarrhoeal disease. The present study assessed the prevalence, molecular characteristics, seasonality and associated clinical features of HAdV infection Tanzanian children below two years of age with and without diarrhoea between 2010–2011. Methods: Stool specimens, demographic and clinical information were collected in 690 cases and 545 controls. All stool samples were screened for HAdV-antigen using ELISA. Positive samples subsequently underwent real-time PCR and sequencing for molecular typing. Results: HAdV was detected in 37 children, corresponding to a prevalence of 3.5% (24/690) in diarrhoeic and 2.4% (13/545) in non-diarrhoeic children (P > 0.05). Among HAdV-infected children, the median age was significantly lower in diarrhoeic than in non-diarrhoeic children (10 vs. 14 months, P˂0.001). More than half of HAdV infected (54.2%) were dehydrated as compared to diarrhoeic children without HAdV (45.8%, P = 0.01). The proportion of the enteric HAdV type 40/41 in diarrhoeic and non-diarrhoeic children was (50.0%, 12/24) and (46.2%, 6/13) respectively. Other HAdV types detected were; 1, 2, 7, 18, 19 and 31. The prevalence of adenovirus was not significantly different between rainy and dry seasons. HAdV was not detected in the 33 known HIV positive children. There was no significant association between HAdV infection and gender, nutritional status of the child and parent educational level. Conclusion: The present study provides further evidence of the contribution of adenovirus in causing gastroenteritis in young children, with symptomatic infection being significantly more prevalent in children below one year. We found similar prevalence of adenovirus in non-diarrhoeic children and in diarrhoeic children. This first report on molecular epidemiology of human adenovirus in Tanzania observed diversity of HAdV types that circulate the study setting. The study findings suggest that HAdV is not an important cause of diarrhoea in young HIV-positive children.en_US
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/9428" target="blank">Viral diarrhoea in children under two years of age in Dar es Salaam, Tanzania. Clinical and molecular epidemiology</a>
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.subjectAdenoviruseng
dc.subjectPCReng
dc.subjectHIVeng
dc.subjectSeasonalityeng
dc.subjectTanzaniaeng
dc.titlePrevalence and molecular characterisation of human adenovirus in diarrhoeic children in Tanzania; a case control studyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-06-29T13:07:34Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2014 The Authors
dc.identifier.doihttps://doi.org/10.1186/s12879-014-0666-1
dc.identifier.cristin1186921
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Infeksjonsmedisin: 776
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Communicable diseases: 776
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Tropemedisin: 761
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Tropical medicine: 761


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