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dc.contributor.authorEngstrøm, Monica Jen_US
dc.contributor.authorOpdahl, Signeen_US
dc.contributor.authorHagen, Anne Ireneen_US
dc.contributor.authorRomundstad, Pål Richarden_US
dc.contributor.authorAkslen, Lars A.en_US
dc.contributor.authorHaugen, Olav A.en_US
dc.contributor.authorVatten, Lars Johanen_US
dc.contributor.authorBofin, Anna M.en_US
dc.PublishedBreast Cancer Research and Treatment 2013, 140(3):463-473eng
dc.description.abstractMolecular subtyping of breast cancer may provide additional prognostic information regarding patient outcome. However, its clinical significance remains to be established. In this study, the main aims were to discover whether reclassification of breast cancer into molecular subtypes provides more precise information regarding outcome compared to conventional histopathological grading and to study breast cancer-specific survival in the different molecular subtypes. Cases of breast cancer occurring in a cohort of women born between 1886 and 1928 with long-term follow-up were included in the study. Tissue microarrays were constructed from archival formalin-fixed, paraffin-embedded tissue from 909 cases. Using immunohistochemistry and in situ hybridisation as surrogates for gene expression analyses, all cases were reclassified into the following molecular subtypes: Luminal A; Luminal B (HER2−); Luminal B (HER2+); HER2 subtype; Basal phenotype; and five negative phenotype. Kaplan–Meier survival curves and Cox proportional hazards models were used in the analyses. During the first 5 years after diagnosis, there were significant differences in prognosis according to molecular subtypes with the best survival for the Luminal A subtype and the worst for HER2 and five negative phenotype. In this historic cohort of women with breast cancer, differences in breast cancer-specific survival according to subtype occur almost exclusively amongst the histopathological grade 2 tumours. From 5 years after time of diagnosis until the end of follow-up, there appears to be no difference in survival according to molecular subtype or histopathological grade.en_US
dc.rightsAttribution CC BY-NCeng
dc.titleMolecular subtypes, histopathological grade and survival in a historic cohort of breast cancer patientsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2013 The Authors
dc.relation.projectNorges forskningsråd: 191778
dc.relation.projectNorges forskningsråd: 223250

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