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dc.contributor.authorKarlsson, Viktoren_US
dc.contributor.authorDankiewicz, Josefen_US
dc.contributor.authorNielsen, Niklasen_US
dc.contributor.authorKern, Karl B.en_US
dc.contributor.authorMooney, Michael R.en_US
dc.contributor.authorRiker, Richard R.en_US
dc.contributor.authorRubertsson, Stenen_US
dc.contributor.authorSeder, David B.en_US
dc.contributor.authorStammet, Pascalen_US
dc.contributor.authorSunde, Kjetilen_US
dc.contributor.authorSøreide, Eldaren_US
dc.contributor.authorUnger, Barbara T.en_US
dc.contributor.authorFriberg, Hansen_US
dc.PublishedCritical Care 2015, 19:182eng
dc.description.abstractIntroduction Previous studies have suggested an effect of gender on outcome after out-of-hospital cardiac arrest (OHCA), but the results are conflicting. We aimed to investigate the association of gender to outcome, coronary angiography (CAG) and adverse events in OHCA survivors treated with mild induced hypothermia (MIH). Methods We performed a retrospective analysis of prospectively collected data from the International Cardiac Arrest Registry. Adult patients with a non-traumatic OHCA and treated with MIH were included. Good neurological outcome was defined as a cerebral performance category (CPC) of 1 or 2. Results A total of 1,667 patients, 472 women (28%) and 1,195 men (72%), met the inclusion criteria. Men were more likely to receive bystander cardiopulmonary resuscitation, have an initial shockable rhythm and to have a presumed cardiac cause of arrest. At hospital discharge, men had a higher survival rate (52% vs. 38%, P <0.001) and more often a good neurological outcome (43% vs. 32%, P <0.001) in the univariate analysis. When adjusting for baseline characteristics, male gender was associated with improved survival (OR 1.34, 95% CI 1.01 to 1.78) but no longer with neurological outcome (OR 1.24, 95% CI 0.92 to 1.67). Adverse events were common; women more often had hypokalemia, hypomagnesemia and bleeding requiring transfusion, while men had more pneumonia. In a subgroup analysis of patients with a presumed cardiac cause of arrest (n = 1,361), men more often had CAG performed on admission (58% vs. 50%, P = 0.02) but this discrepancy disappeared in an adjusted analysis. Conclusions Gender differences exist regarding cause of arrest, adverse events and outcome. Male gender was independently associated with survival but not with neurological outcome.en_US
dc.rightsAttribution CC BYeng
dc.subjectcardiac arresteng
dc.subjectInternational Cardiac Arrest Registryeng
dc.titleAssociation of gender to outcome after out-of-hospital cardiac arrest - a report from the International Cardiac Arrest Registryen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright Karlsson et al.; licensee BioMed Central. 2015
dc.subject.nsiVDP::Medisinske fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803
dc.subject.nsiVDP::Midical sciences: 700::Health sciences: 800::Epidemiology, medical and dental statistics: 803
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Cardiology: 771
dc.subject.nsiVDP::Medisinske Fag: 700en_US

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