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dc.contributor.authorJuvik, Ole-Johanen_US
dc.contributor.authorNguyen, Xuan Hong Thyen_US
dc.contributor.authorAndersen, Heidi Lieen_US
dc.contributor.authorFossen, Torgilsen_US
dc.PublishedPhytochemistry Reviews 2015eng
dc.description.abstractAfter the sensational rediscovery of living exemplars of the Cretaceous relict Metasequoia glyptostroboides—a tree previously known exclusively from fossils from various locations in the northern hemisphere, there has been an increasing interest in discovery of novel natural products from this unique plant source. This article includes the first complete compilation of natural products reported from M. glyptostroboides during the entire period in which the tree has been investigated (1954–2014) with main focus on the compounds specific to this plant source. Studies on the biological activity of pure compounds and extracts derived from M. glyptostroboides are reviewed for the first time. The unique potential of M. glyptostroboides as a source of bioactive constituents is founded on the fact that the tree seems to have survived unchanged since the Cretaceous era. Since then, its molecular defense system has resisted the attacks of millions of generations of pathogens. In line with this, some recent landmarks in Metasequoia paleobotany are covered. Initial spectral analysis of recently discovered intact 53 million year old wood and amber of Metasequoia strongly indicate that the tree has remained unchanged for millions of years at the molecular level.en_US
dc.relation.ispartof<a href="" target="_blank">Characterization of bioactive natural products from edible, medicinal and toxic plants</a>
dc.rightsAttribution CC BYeng
dc.subjectMetasequoia glyptostroboideseng
dc.subjectnatural productseng
dc.titleGrowing with dinosaurs: natural products from the Cretaceous relict Metasequoia glyptostroboides Hu & Cheng - a molecular reservoir from the ancient world with potential in modern medicineen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright The Author(s) 2015
dc.subject.nsiVDP::Matematikk og naturvitenskap: 400::Kjemi: 440::Legemiddelkjemi: 448
dc.subject.nsiVDP::Mathematics and natural scienses: 400::Chemistry: 440::Pharmaceutical chemistry: 448
dc.subject.nsiVDP::Matematikk og Naturvitenskap: 400en_US

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