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dc.contributor.authorChen, Chi-Huaen_US
dc.contributor.authorPeng, Qianen_US
dc.contributor.authorSchork, Andrew J.en_US
dc.contributor.authorLo, Min-Tzuen_US
dc.contributor.authorFan, Chun-Chiehen_US
dc.contributor.authorWang, Yunpengen_US
dc.contributor.authorDesikan, Rahul S.en_US
dc.contributor.authorBettella, Franscescoen_US
dc.contributor.authorHagler, Donald J.en_US
dc.contributor.authorWestlye, Lars Tjeltaen_US
dc.contributor.authorKremen, William S.en_US
dc.contributor.authorJernigan, Terry L.en_US
dc.contributor.authorLe Hellard, Stephanieen_US
dc.contributor.authorSteen, Vidar Martinen_US
dc.contributor.authorEspeseth, Thomasen_US
dc.contributor.authorHuentelman, Matten_US
dc.contributor.authorHåberg, Astaen_US
dc.contributor.authorAgartz, Ingriden_US
dc.contributor.authorDjurovic, Srdjanen_US
dc.contributor.authorAndreassen, Ole Andreasen_US
dc.contributor.authorSchork, Nicholasen_US
dc.contributor.authorDale, Andersen_US
dc.PublishedNature Communications 2015, 6:7549eng
dc.description.abstractLittle is known about how genetic variation contributes to neuroanatomical variability, and whether particular genomic regions comprising genes or evolutionarily conserved elements are enriched for effects that influence brain morphology. Here, we examine brain imaging and single-nucleotide polymorphisms (SNPs) data from ~2,700 individuals. We show that a substantial proportion of variation in cortical surface area is explained by additive effects of SNPs dispersed throughout the genome, with a larger heritable effect for visual and auditory sensory and insular cortices (h2~0.45). Genome-wide SNPs collectively account for, on average, about half of twin heritability across cortical regions (N=466 twins). We find enriched genetic effects in or near genes. We also observe that SNPs in evolutionarily more conserved regions contributed significantly to the heritability of cortical surface area, particularly, for medial and temporal cortical regions. SNPs in less conserved regions contributed more to occipital and dorsolateral prefrontal cortices.en_US
dc.publisherNature Publishing Groupeng
dc.rightsAttribution CC BYeng
dc.titleLarge-scale genomics unveil polygenic architecture of human cortical surface areaen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2015 The Authors
dc.subject.nsiVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714
dc.subject.nsiVDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical genetics: 714

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