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dc.contributor.authorAahlin, Eirik Kjusen_US
dc.contributor.authorTranø, Geiren_US
dc.contributor.authorJohns, Neilen_US
dc.contributor.authorHorn, Arilden_US
dc.contributor.authorSøreide, Jon Arneen_US
dc.contributor.authorFearon, Kenneth Christopher H.en_US
dc.contributor.authorRevhaug, Arthuren_US
dc.contributor.authorLassen, Kristofferen_US
dc.date.accessioned2015-12-31T10:17:33Z
dc.date.available2015-12-31T10:17:33Z
dc.date.issued2015-07-07
dc.PublishedBMC Surgery 2015, 15:83eng
dc.identifier.issn1471-2482
dc.identifier.urihttps://hdl.handle.net/1956/10845
dc.description.abstractBackground: Preoperative weight loss and abnormal serum-albumin have traditionally been associated with reduced survival. More recently, a correlation between postoperative complications and reduced long-term survival has been reported and the significance of the relative proportion of skeletal muscle, visceral and subcutaneous adipose tissue has been examined with conflicting results. We investigated how preoperative body composition and major non-fatal complications related to overall survival and compared this to established predictors in a large cohort undergoing upper abdominal surgery. Methods: From 2001 to 2006, 447 patients were included in a Norwegian multicenter randomized controlled trial in major upper abdominal surgery. Patients were now, six years later, analyzed as a single prospective cohort and overall survival was retrieved from the National Population Registry. Body composition indices were calculated from CT images taken within three months preoperatively. Results: Preoperative serum-albumin <35 g/l (HR = 1.52, p = 0 .014) and weight loss >5 % (HR = 1.38, p = 0.023) were independently associated with reduced survival. There was no association between any of the preoperative body composition indices and reduced survival. Major postoperative complications were independently associated with reduced survival but only as long as patients who died within 90 days were included in the analysis. Conclusions: Our study has confirmed the robust significance of the traditional indicators, preoperative serum-albumin and weight loss. The body composition indices did not prove beneficial as global indicators of poor prognosis in upper abdominal surgery. We found no association between non-fatal postoperative complications and long-term survival.en_US
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.subjectSarcopeniaeng
dc.subjectCachexiaeng
dc.subjectCancereng
dc.subjectGastrointestinaleng
dc.subjectHepatopancreatobiliaryeng
dc.subjectSurgeryeng
dc.titleRisk factors, complications and survival after upper abdominal surgery: A prospective cohort studyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-11-09T14:15:54Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2015 The Authors
dc.identifier.doihttps://doi.org/10.1186/s12893-015-0069-2
dc.identifier.cristin1259037
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Kar- og thoraxkirurgi: 782
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Vascular and thoracic surgery: 782


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