dc.contributor.author | Karlsen, Marie | en_US |
dc.contributor.author | Hansen, Torbjørn | en_US |
dc.contributor.author | Nordal, Hilde Haugedal | en_US |
dc.contributor.author | Brun, Johan G | en_US |
dc.contributor.author | Jonsson, Roland | en_US |
dc.contributor.author | Appel, Silke | en_US |
dc.date.accessioned | 2016-01-28T14:11:51Z | |
dc.date.available | 2016-01-28T14:11:51Z | |
dc.date.issued | 2015-03-19 | |
dc.Published | PLoS ONE 2015, 10(3):e0120383 | eng |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://hdl.handle.net/1956/11018 | |
dc.description.abstract | Introduction: Sjögren’s syndrome (SS) is a rheumatic autoimmune disease characterized by inflammation of exocrine glands. As autoantibodies are present in a majority of patients, B cells have been suggested to play an important role in onset and development of the disease. Toll-like receptors (TLRs) are pattern recognition receptors triggering innate immune responses. Since an increased expression of TLRs has been detected in other rheumatic diseases the purpose of this study was to explore TLRs in B cells of SS patients. Methods: The expression of TLR-7 and -9 in B cell subsets of 25 patients with primary SS (pSS) and 25 healthy controls was analysed in peripheral blood using flow cytometry and real time quantitative PCR. Results: We detected similar levels of CD19+ B cells in pSS patients and healthy controls. An increased number of naïve B cells, as well as fewer pre-switched memory B cells were found in pSS patients. No significant differences were observed in TLR-7 and -9 expression in B cells between pSS patients and healthy controls. Conclusion: This study shows that pSS patients have an alteration in the B cell subpopulation composition compared to controls, with less pre-switched memory B cells and more naïve B cells. We did not detect any significant disparities in TLR-7 and -9 expression between the two groups. | en_US |
dc.language.iso | eng | eng |
dc.publisher | PLOS | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0 | eng |
dc.title | Expression of toll-like receptor -7 and -9 in B cell subsets from patients with primary Sjögren's syndrome | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-12-21T20:08:36Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2015 The Authors | |
dc.identifier.doi | https://doi.org/10.1371/journal.pone.0120383 | |
dc.identifier.cristin | 1246843 | |
dc.subject.nsi | VDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716 | |
dc.subject.nsi | VDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical immunology: 716 | |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759 | |
dc.subject.nsi | VDP::Midical sciences: 700::Clinical medical sciences: 750::Rheumatology: 759 | |