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dc.contributor.authorKnoop, Thomasen_US
dc.contributor.authorVågane, Ann Meretheen_US
dc.contributor.authorVikse, Bjørn Egilen_US
dc.contributor.authorSvarstad, Einaren_US
dc.contributor.authorMagnusdottir, Bergrun Tinnaen_US
dc.contributor.authorLeh, Sabine Mariaen_US
dc.contributor.authorReisæter, Anna Varbergen_US
dc.contributor.authorBjørneklett, Runeen_US
dc.PublishedAmerican Journal of Nephrology 2015, 41(3):210-219eng
dc.description.abstractBackground: Predicting outcome in individual patients with IgA nephropathy (IgAN) is difficult but important. For this purpose, the absolute renal risk (ARR) model has been developed in a French cohort to calculate the risk of end-stage renal disease (ESRD) and death. ARR (0-3) is scored in individual IgAN patients based on the presence of proteinuria ≥1 g/24 h, hypertension, and severe histopathological lesions (1 point per risk factor). We have validated the ARR model in a Norwegian cohort of IgAN patients and tested whether adding data on initial estimated glomerular filtration rate (eGFR) and age improved prediction. Methods: IgAN patients diagnosed between 1988 and 2012 were identified in the Norwegian Kidney Biopsy Registry, and endpoints were identified by record linkage with the Norwegian Renal Registry (ESRD) and the Population Registry (deaths). Results: We identified 1,134 IgAN patients. The mean duration of follow-up was 10.2 years (range 0.0 to 25.7 years). Two hundred and fifty one patients developed ESRD and there were 69 pre-ESRD deaths. The ARR model significantly stratified the IgAN cohort according to risk of ESRD/death. The inclusion of eGFR and age significantly improved the ARR prognostic model; in the receiver operator characteristics (ROC) analysis, area under the curve (AUC) at 10-years of follow-up increased from 0.79 to 0.89, p < 0.001. Conclusions: ARR is a suitable prognostic model for stratifying IgAN patients according to the risk of ESRD or death. Including initial eGFR and age in the model substantially improved its accuracy in our nationwide cohort.en_US
dc.rightsAttribution CC BY-NCeng
dc.subjectEnd-stage renal diseaseeng
dc.subjectImmunoglobulin A nephropathyeng
dc.subjectRisk factoreng
dc.titleAddition of eGFR and age improves the prognostic absolute renal risk-model in 1,134 norwegian patients with IgA nephropathyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2015 S. Karger AG, Basel
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Nefrologi, urologi: 772
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Nephrology, urology: 772

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