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dc.contributor.authorCramariuc, Danaen_US
dc.contributor.authorRogge, Barbaraen_US
dc.contributor.authorLønnebakken, Mai Toneen_US
dc.contributor.authorBoman, Kurten_US
dc.contributor.authorBahlmann, Eddaen_US
dc.contributor.authorGohlke-Bärwolf, Christaen_US
dc.contributor.authorChambers, John B.en_US
dc.contributor.authorPedersen, Terje Rolfen_US
dc.contributor.authorGerdts, Evaen_US
dc.date.accessioned2016-02-09T12:47:47Z
dc.date.available2016-02-09T12:47:47Z
dc.date.issued2015
dc.PublishedHeart 2015, 101(3):209-214eng
dc.identifier.issn1468-201X
dc.identifier.urihttps://hdl.handle.net/1956/11058
dc.description.abstractObjective: Women with severe aortic valve stenosis (AS) have better LV systolic function and more concentric LV geometry than their male counterparts. However, sex differences in cardiovascular (CV) outcome during progression of AS have not been reported from a longitudinal prospective study. Methods: Doppler echocardiography and CV events were recorded during a median of 4.0 years in 979 men and 632 women aged 28–86 (mean 67±10) years in the Simvastatin Ezetimibe in Aortic Stenosis (SEAS) study. LV systolic function was assessed by EF and midwall shortening (MWS). Study outcomes were AS-related events, ischaemic CV events and total mortality. Results: The annular cumulative incidence of AS events, ischaemic CV events and death was 8.1%, 3.4% and 2.8% in women, and 8.9%, 4.4% and 2.4% in men, respectively. Women and men had similar AS progression rate whether measured by peak jet velocity, mean gradient or valve area. In multivariate analyses, female sex independently predicted less reduction in LV MWS and EF during follow-up (both p<0.05). In time-varying Cox analyses, women had a 40% lower rate of ischaemic CV events (95% CI 21% to 54%), in particular, more than 50% lower rate of stroke and coronary artery bypass grafting, and a 31% lower all-cause mortality (95% CI 1% to 51%), independent of active study treatment, age and hypertension, as well as time-varying valve area, low systolic function and abnormal LV geometry. AS event rate did not differ by sex. Conclusions: In the SEAS study, women and men had similar rates of AS progression and AS-related events. However, women had lower total mortality and ischaemic CV event rate than men independent of confounders.en_US
dc.language.isoengeng
dc.publisherBMJeng
dc.rightsAttribution CC BY-NCeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/eng
dc.titleSex differences in cardiovascular outcome during progression of aortic valve stenosisen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-12-30T16:58:52Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2015 The Authors
dc.identifier.doihttps://doi.org/10.1136/heartjnl-2014-306078
dc.identifier.cristin1212078
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Cardiology: 771


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