Now showing items 8610-8629 of 9790

    • Structural changes induced by electroconvulsive therapy are associated with clinical outcome 

      Mulders, Peter C. R.; Llera, Alberto; Beckmann, Christian F.; Vandenbulcke, Mathieu; Stek, Max L; Sienaert, Pascal; Redlich, Ronny; Petrides, Georgios; Oudega, Mardien L.; Oltedal, Leif; Ødegaard, Ketil Joachim; Narr, Katherine L; Magnusson, Peter; Kessler, Ute; Jorgensen, Anders; Espinoza, Randall; Enneking, Verena; Emsell, Louise; Dols, Annemieke; Dannlowski, Udo; Bolwig, Tom G; Bartsch, Hauke; Argyelan, Miklos; Anand, Amit; Abbott, Christopher; van Eijndhoven, Philip; Tendolkar, Indira (Journal article; Peer reviewed, 2020)
      Background Electroconvulsive therapy (ECT) is the most effective treatment option for major depressive disorder, so understanding whether its clinical effect relates to structural brain changes is vital for current and ...
    • Structural imaging findings are related to clinical complications in chronic pancreatitis 

      Nordaas, Ingrid Kvåle; Tjora, Erling; Dimcevski, Georg Gjorgji; Haldorsen, Ingfrid S.; Olesen, Søren Schou; Drewes, Asbjørn Mohr; Zviniene, Kristina; Barauskas, Giedrius; Bayram, Berivan Kyed; Nørregaard, Peter; Borch, Anders; Nøjgaard, Camilla; Jensen, Annette Bøjer; Kardasheva, Svetlana S.; Okhlobystin, Alexey; Hauge, Truls; Waage, Anne; Frøkjær, Jens Brøndum; Engjom, Trond (Journal article; Peer reviewed, 2022)
      Background/objectives: Structural pancreatic changes and complications related to chronic pancreatitis are well described, but little is known about their relationship. We aimed to explore the associations between pancreatic ...
    • Structural insights into Charcot–Marie–Tooth disease-linked mutations in human GDAP1 

      Sutinen, Aleksi; Nguyen, Giang Thi Tuyet; Raasakka, Arne; Muruganandam, Gopinath; Loris, Remy; Ylikallio, Emil; Tyynismaa, Henna; Bartesaghi, Luca; Ruskamo, Salla; Kursula, Petri (Journal article; Peer reviewed, 2022)
      Charcot–Marie–Tooth disease (CMT) is the most common inherited peripheral polyneuropathy in humans, and its different subtypes are linked to mutations in dozens of different genes. Mutations in ganglioside-induced ...
    • Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation 

      Bueno-Carrasco, María Teresa; Cuellar, Jorge; Flydal, Marte Innselset; Santiago, Cesar; Kråkenes, Trond-André; Kleppe, Rune; Jose R, Lopez-Blanco; Marcilla, Miguel; Teigen, Knut; Alvira, Sara; Chacón, Pablo; Martinez, Aurora; Valpuesta, José M (Journal article; Peer reviewed, 2022)
      Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of dopamine (DA) and other catecholamines, and its dysfunction leads to DA deficiency and parkinsonisms. Inhibition by catecholamines and ...
    • Structural Operational Semantics for Heterogeneously Typed Coalgebras 

      König, Harald; Wolter, Uwe Egbert; Kräuter, Tim Oliver (Journal article; Peer reviewed, 2023)
      Concurrently interacting components of a modular software architecture are heterogeneously structured behavioural models. We consider them as coalgebras based on different endofunctors. We formalize the composition of these ...
    • Structural Parameterizations of b-Coloring 

      Jaffke, Lars; Lima, Paloma Thome de; Sharma, Roohani (Journal article; Peer reviewed, 2023)
      The b-Coloring problem, which given a graph G and an integer k asks whether G has a proper k-coloring such that each color class has a vertex adjacent to all color classes except its own, is known to be FPT parameterized ...
    • Structural parameterizations of clique coloring 

      Jaffke, Lars; Lima, Paloma T.; Philip, Geevarghese (Journal article; Peer reviewed, 2020)
      A clique coloring of a graph is an assignment of colors to its vertices such that no maximal clique is monochromatic. We initiate the study of structural parameterizations of the Clique Coloring problem which asks whether ...
    • Structural proof theory for first-order weak Kleene logics 

      Fjellstad, Andreas (Journal article; Peer reviewed, 2020)
      This paper presents a sound and complete five-sided sequent calculus for first-order weak Kleene valuations which permits not only elegant representations of four logics definable on first-order weak Kleene valuations, but ...
    • Structural properties and peptide ligand binding of the capsid homology domains of human Arc 

      Hallin, Erik Ingmar; Bramham, Clive Raymond Evjen; Kursula, Petri (Journal article; Peer reviewed, 2021)
      The activity-regulated cytoskeleton-associated protein (Arc) is important for synaptic plasticity and the normal function of the brain. Arc interacts with neuronal postsynaptic proteins, but the mechanistic details of its ...
    • Structural reconstructions of the Eastern Barents Sea at Meso-Tertiary evolution and influence on petroleum potential 

      Suslova, Anna A.; Stoupakova, Antonina V.; Mordasova, Alina V.; Sautkin, Roman S.; Gilmullina, Albina (Journal article; Peer reviewed, 2021)
      Barents Sea basin is the most explored and studied by the regional and petroleum geologists on the Russian Arctic shelf and has approved gas reserves. However, there are many questions in the petroleum exploration, one of ...
    • Structure and drivers of ocean mixing north of Svalbard in summer and fall 2018 

      Koenig, Zoe Charlotte; Kolås, Eivind Hugaas; Fer, Ilker (Journal article; Peer reviewed, 2021)
      The Arctic Ocean is a major sink for heat and salt for the global ocean. Ocean mixing contributes to this sink by mixing the Atlantic- and Pacific-origin waters with surrounding waters. We investigate the drivers of ocean ...
    • Structure and function of an atypical homodimeric actin capping protein from the malaria parasite 

      Bendes, Ábris Ádám; Kursula, Petri; Kursula, Inari (Journal article; Peer reviewed, 2022)
      Apicomplexan parasites, such as Plasmodium spp., rely on an unusual actomyosin motor, termed glideosome, for motility and host cell invasion. The actin filaments are maintained by a small set of essential regulators, which ...
    • Structure and functioning of four North Atlantic ecosystems - A comparative study 

      Melle, Webjørn Raunsgård; Klevjer, Thor A.; Drinkwater, Kenneth F.; Strand, Espen; Naustvoll, Lars Johan; Wiebe, Peter H.; Aksnes, Dag Lorents; Knutsen, Tor; Sundby, Svein; Slotte, Aril; Dupont, Nicolas; Salvanes, Anne Gro Vea; Korneliussen, Rolf; Huse, Geir (Journal article; Peer reviewed, 2020)
      The epi- and mesopelagic ecosystems of four sub-polar ocean basins, the Labrador, Irminger, Iceland and Norwegian seas, were surveyed during two legs from Bergen, Norway, to Nuuk, Greenland, and back to Bergen. The survey ...
    • Structure and kinematics of an extensional growth fold, Hadahid Fault System, Suez Rift, Egypt 

      Jackson, Christopher A.-L.; Whipp, Paul S.; Gawthorpe, Robert; Lewis, Matthew M. (Journal article; Peer reviewed, 2020)
      Normal faulting drives extensional growth folding of the Earth's upper crust during continental extension, yet we know little of how fold geometry relates to the structural segmentation of the underlying fault. We use field ...
    • Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase 

      Mahootchi, Elaheh; Raasakk, Arne; Luan, Weisha; Muruganandam, Gopinath; Loris, Remy; Haavik, Jan; Kursula, Petri (Journal article; Peer reviewed, 2021)
      Pyridoxal 5́-phosphate (PLP) is an important cofactor for amino acid decarboxylases with many biological functions, including the synthesis of signalling molecules, such as serotonin, dopamine, histamine, γ-aminobutyric ...
    • Structure and Transport of Atlantic Water North of Svalbard From Observations in Summer and Fall 2018 

      Kolås, Eivind; Koenig, Zoé Charlotte; Fer, Ilker; Nilsen, Frank; Marnela, Marika (Journal article; Peer reviewed, 2020)
      The transport of warm Atlantic Waters north of Svalbard is one of the major heat and salt sources to the Arctic Ocean. The circulation pathways and the associated heat transport influence the variability in the Arctic sea ...
    • Structure of POPC Lipid Bilayers in OPLS3e Force Field 

      Kurki, Milla; Poso, Antti; Bartos, Piia; Miettinen, Markus (Journal article; Peer reviewed, 2022)
      It is crucial for molecular dynamics simulations of biomembranes that the force field parameters give a realistic model of the membrane behavior. In this study, we examined the OPLS3e force field for the carbon−hydrogen ...
    • Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment 

      Lillebostad, Peder August Gudmundsen; Raasakka, Arne; Hjellbrekke, Silje Johannessen; Patil, Sudarshan; Røstbø, Trude Kvalnes; Hollås, Hanne; Sakya, Siri; Szigetvari, Peter Daniel; Vedeler, Anni; Kursula, Petri (Journal article; Peer reviewed, 2020)
      The functions of the annexin family of proteins involve binding to Ca2+, lipid membranes, other proteins, and RNA, and the annexins share a common folded core structure at the C terminus. Annexin A11 (AnxA11) has a long ...
    • Structure of the Complete Dimeric Human GDAP1 Core Domain Provides Insights into Ligand Binding and Clustering of Disease Mutations 

      Nguyen, Giang Thi Tuyet; Sutinen, Aleksi; Raasakka, Arne; Muruganandam, Gopinath; Loris, Remy; Kursula, Petri (Journal article; Peer reviewed, 2021)
      Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders. Despite the common involvement of ganglioside-induced differentiation-associated protein 1 (GDAP1) in CMT, the protein structure ...
    • Structure of the mouse acidic amino acid decarboxylase GADL1 

      Raasakka, Arne; Mahootchi, Elaheh; Winge, Ingeborg; Luan, Weisha; Kursula, Petri; Haavik, Jan (Journal article; Peer reviewed, 2018)
      Pyridoxal 5′-phosphate (PLP) is a ubiquitous cofactor in various enzyme classes, including PLP-dependent decarboxylases. A recently discovered member of this class is glutamic acid decarboxylase-like protein 1 (GADL1), ...