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dc.contributor.authorEtokebe, Godfreyen_US
dc.contributor.authorZienolddiny, Shanbehen_US
dc.contributor.authorKupanovac, Zeljkoen_US
dc.contributor.authorEnersen, Mortenen_US
dc.contributor.authorBalen, Sanjaen_US
dc.contributor.authorFlego, Velkjoen_US
dc.contributor.authorBulat-Kardum, Ljiljanaen_US
dc.contributor.authorRadojčić-Badovinac, Anđelkaen_US
dc.contributor.authorSkaug, Vidaren_US
dc.contributor.authorBakke, Per S.en_US
dc.contributor.authorHaugen, Aageen_US
dc.contributor.authorDembic, Zlatkoen_US
dc.date.accessioned2016-03-16T10:59:41Z
dc.date.available2016-03-16T10:59:41Z
dc.date.issued2015-04-17
dc.PublishedPLoS ONE 2015, 10(4)eng
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1956/11674
dc.description.abstractWe analyzed for associations between a variable number of tandem repeat (VNTR) polymorphism in the Family with sequence similarity 46, member A (FAM46A) gene and a single nucleotide polymorphism (rs3117582) in the BCL2-Associated Athanogene 6 (BAG6) with non small cell lung cancer in Croatian and Norwegian subjects. A total of 503 (262 Croatian and 241Norwegian) non small cell lung cancer patients and 897 controls (568 Croatian and 329 Norwegian) were analyzed. We found that the frequency of allele b (three VNTR repeats) of FAM46A gene was significantly increased in the patients compared to the healthy controls in the Croatian and the combined Croatian and Norwegian subjects. Genotype frequencies of cd (four and five VNTR repeats) and cc (four VNTR repeats homozygote) of the FAM46A gene were significantly decreased in the patients compared to the healthy controls in the Croatian and Norwegian subjects, respectively. Logistic regression analyses revealed FAM46A genotype cc to be an independent predictive factor for non small cell lung cancer risk in the Norwegian subjects after adjustment for age, gender and smoking status. This is the first study to suggest an association between the FAM46A gene VNTR polymorphisms and non small cell lung cancer. We found also that BAG6 rs3117582 SNP was associated with non small cell lung cancer in the Norwegian subjects and the combined Croatian-Norwegian subjects corroborating the earlier finding that BAG6 rs3117582 SNP was associated with lung cancer in Europeans. Logistic regression analyses revealed that genotypes and alleles of BAG6 were independent predictive factor for non small cell lung cancer risk in the Norwegian and combined Croatian-Norwegian subjects, after adjustment for age and gender.en_US
dc.language.isoengeng
dc.publisherPLOS ONEeng
dc.rightsAttribution CC BY 4.0eng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.titleAssociation of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populationsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-11-26T14:02:25Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2015 Etokebe et al.
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0122651
dc.identifier.cristin1181850
dc.subject.nsiVDP::Medisinske fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803
dc.subject.nsiVDP::Midical sciences: 700::Health sciences: 800::Epidemiology, medical and dental statistics: 803
dc.subject.nsiVDP::Medisinske Fag: 700en_US


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Attribution CC BY 4.0
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