dc.contributor.author | Engjom, Trond | en_US |
dc.contributor.author | Erchinger, Friedemann Georg | en_US |
dc.contributor.author | Lærum, Birger Norderud | en_US |
dc.contributor.author | Tjora, Erling | en_US |
dc.contributor.author | Aksnes, Lage | en_US |
dc.contributor.author | Gilja, Odd Helge | en_US |
dc.contributor.author | Dimcevski, Georg Gjorgji | en_US |
dc.date.accessioned | 2016-03-31T10:41:45Z | |
dc.date.available | 2016-03-31T10:41:45Z | |
dc.date.issued | 2015-02-16 | |
dc.Published | Pancreas 2015, 44(8):1266-1272 | eng |
dc.identifier.issn | 1536-4828 | |
dc.identifier.uri | https://hdl.handle.net/1956/11787 | |
dc.description.abstract | Objective: Short endoscopic secretin tests for exocrine pancreatic function are not properly evaluated in cystic fibrosis (CF). Methods: Patients with CF and healthy controls (HCs) underwent endoscopic collection of duodenal juice between 30 and 45 minutes after secretin stimulation. Duodenal juice was analyzed for HCO3- concentration and pancreatic enzyme activities. Stool was analyzed for fecal elastase. Results: Thirty-one patients with CF and 25 HCs were tested. Patients were classified as exocrine pancreatic sufficient (n = 13) or insufficient (n = 18). Both bicarbonate concentrations and enzyme activities in duodenal juice differentiated patients with CFI from patients with CFS and HC (P < 0.001). The population displays strong correlation between severe CF genotype in both alleles and pancreatic insufficient phenotype (P < 0.001). Conclusions: Pancreatic exocrine insufficient CF patients could be differentiated from exocrine sufficient patients and HCs using short endoscopic secretin test. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Wolters Kluwer | eng |
dc.rights | Attribution CC BY-NC-ND | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | eng |
dc.subject | pancreas | eng |
dc.subject | cystic fibrosis | eng |
dc.subject | exocrine pancreatic function | eng |
dc.subject | secretin | eng |
dc.subject | endoscopy | eng |
dc.title | Diagnostic accuracy of a short endoscopic secretin test in patients with cystic fibrosis | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-12-30T17:14:09Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2015 Wolters Kluwer Health, Inc | |
dc.identifier.doi | https://doi.org/10.1097/mpa.0000000000000425 | |
dc.identifier.cristin | 1291741 | |