dc.contributor.author | Uppada, Dharma Rao | en_US |
dc.contributor.author | Selvam, Sumithra | en_US |
dc.contributor.author | Jesuraj, Nelson | en_US |
dc.contributor.author | Bennett, Sean | en_US |
dc.contributor.author | Verver, Suzanne | en_US |
dc.contributor.author | Grewal, Harleen | en_US |
dc.contributor.author | Vaz, Mario | en_US |
dc.date.accessioned | 2016-03-31T12:31:03Z | |
dc.date.available | 2016-03-31T12:31:03Z | |
dc.date.issued | 2014-11-18 | |
dc.Published | BMC Infectious Diseases 2014, 14(571) | eng |
dc.identifier.issn | 1471-2334 | |
dc.identifier.uri | https://hdl.handle.net/1956/11798 | |
dc.description.abstract | Background. India has generally used 1 TU purified protein derivative (PPD) as opposed to 2 TU PPD globally, limiting comparisons. It is important to assess latent TB infection in adolescents given that they may be a target group for new post-exposure TB vaccines. The aim of this study is to describe the pattern and associations of tuberculin skin test (TST) responses (0.1 ml 2 TU) in adolescents in South India. Methods. 6643 school-going adolescents (11 to <18 years) underwent TST. Trained tuberculin reader made the reading visit between 48 and 96 hours after the skin test. Results. Of 6608 available TST results, 9% had 0 mm, and 12% ≥10 mm responses. The proportion of TST positive (≥10 mm) was higher among older children, boys, those with a history of TB contact and reported BCG immunization Those with no TST response (0 mm) included younger participants (<14 years), those whose mothers were illiterate and those with a recent history of weight loss. Those of a higher socio-economic status (houses with brick walls, LPG gas as cooking fuel) and those with a visible BCG scar were less likely to be non-responders. Conclusion. Proportion of non-responders was lower than elsewhere in the world. Proportion of TST positivity was higher in those already exposed to TB and in children who had been BCG immunized, with a zero response more likely in younger adolescents and those with recent weight loss. | en_US |
dc.language.iso | eng | eng |
dc.publisher | BioMed Central | eng |
dc.rights | Attribution CC BY 4.0 | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0 | eng |
dc.subject | Tuberculosis | eng |
dc.subject | Latent tuberculosis infection | eng |
dc.subject | Tuberculin skin test | eng |
dc.subject | Children | eng |
dc.title | The tuberculin skin test in school going adolescents in South India: associations of socio-demographic and clinical characteristics with TST positivity and non-response | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-12-01T12:55:43Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright Uppada et al.; licensee BioMed Central Ltd. 2014 | |
dc.identifier.doi | https://doi.org/10.1186/s12879-014-0571-7 | |
dc.identifier.cristin | 1232192 | |
dc.subject.nsi | VDP::Medisinske fag: 700::Helsefag: 800::Forebyggende medisin: 804 | |
dc.subject.nsi | VDP::Midical sciences: 700::Health sciences: 800::Preventive medicine: 804 | |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Infeksjonsmedisin: 776 | |
dc.subject.nsi | VDP::Midical sciences: 700::Clinical medical sciences: 750::Communicable diseases: 776 | |
dc.subject.nsi | VDP::Medisinske Fag: 700 | en_US |