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dc.contributor.authorRajilic-Stojanovic, Mirjanaen_US
dc.contributor.authorJonkers, Daisy Men_US
dc.contributor.authorSalonen, Anneen_US
dc.contributor.authorHanevik, Kurten_US
dc.contributor.authorRaes, Jeroenen_US
dc.contributor.authorJalanka, Jonnaen_US
dc.contributor.authorde Vos, Willem Men_US
dc.contributor.authorManichanh, Chaysavanhen_US
dc.contributor.authorGolic, Natasaen_US
dc.contributor.authorEnck, Paulen_US
dc.contributor.authorElena, Philippouen_US
dc.contributor.authorIraqi, Fuad Aen_US
dc.contributor.authorClarke, Gerarden_US
dc.contributor.authorSpiller, Robin Cen_US
dc.contributor.authorPenders, Johnen_US
dc.PublishedAmerican Journal of Gastroenterology 2015, 110(2):278-287eng
dc.description.abstractIrritable bowel syndrome (IBS) is a heterogeneous functional disorder with a multifactorial etiology that involves the interplay of both host and environmental factors. Among environmental factors relevant for IBS etiology, the diet stands out given that the majority of IBS patients report their symptoms to be triggered by meals or specific foods. The diet provides substrates for microbial fermentation, and, as the composition of the intestinal microbiota is disturbed in IBS patients, the link between diet, microbiota composition, and microbial fermentation products might have an essential role in IBS etiology. In this review, we summarize current evidence regarding the impact of diet and the intestinal microbiota on IBS symptoms, as well as the reported interactions between diet and the microbiota composition. On the basis of the existing data, we suggest pathways (mechanisms) by which diet components, via the microbial fermentation, could trigger IBS symptoms. Finally, this review provides recommendations for future studies that would enable elucidation of the role of diet and microbiota and how these factors may be (inter)related in the pathophysiology of IBS.en_US
dc.publisherNature Publishing Groupeng
dc.rightsAttribution CC BY-NC-NDeng
dc.titleIntestinal microbiota and diet in IBS: causes, consequences, or epiphenomena?en_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2015 the authors

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