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dc.contributor.authorTriebner, Kaien_US
dc.contributor.authorJohannessen, Aneen_US
dc.contributor.authorPuggini, Lucaen_US
dc.contributor.authorBenediktsdottir, Bryndisen_US
dc.contributor.authorBertelsen, Randi Jacobsenen_US
dc.contributor.authorBifulco, Ersiliaen_US
dc.contributor.authorDharmage, Shyamali C.en_US
dc.contributor.authorFranklin, Karl A.en_US
dc.contributor.authorGislason, Þórarinnen_US
dc.contributor.authorHolm, Mathiasen_US
dc.contributor.authorJarvis, Deborahen_US
dc.contributor.authorLeynaert, Bénédicteen_US
dc.contributor.authorLindberg, Evaen_US
dc.contributor.authorMacsali, Ferencen_US
dc.contributor.authorMalinovschi, Andrejen_US
dc.contributor.authorNorbäck, Danen_US
dc.contributor.authorOmenaas, Ernsten_US
dc.contributor.authorRodriguez, Francisco Jen_US
dc.contributor.authorSaure, Eirunn Waateviken_US
dc.contributor.authorSchlünssen, Vivien_US
dc.contributor.authorSigsgaard, Torbenen_US
dc.contributor.authorSkorge, Trude Duelienen_US
dc.contributor.authorWieslander, Gunillaen_US
dc.contributor.authorZemp, Elisabethen_US
dc.contributor.authorSvanes, Cecilieen_US
dc.contributor.authorHustad, Simon Steinaren_US
dc.contributor.authorGomez Real, Franciscoen_US
dc.PublishedJournal of Allergy and Clinical Immunology 2015, 137(1):50-57eng
dc.description.abstractBackground: There is limited and conflicting evidence on the effect of menopause on asthma. Objectives: We sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal population-based study with an average follow-up of 12 years. Methods: The Respiratory Health in Northern Europe study provided questionnaire data pertaining to respiratory and reproductive health at baseline (1999-2001) and follow-up (2010-2012). The study cohort included women aged 45 to 65 years at follow-up, without asthma at baseline, and not using exogenous hormones (n 5 2322). Menopausal status was defined as nonmenopausal, transitional, early postmenopausal, and late postmenopausal. Associations with asthma (defined by the use of asthma medication, having asthma attacks, or both) and respiratory symptoms scores were analyzed by using logistic (asthma) and negative binomial (respiratory symptoms) regressions, adjusting for age, body mass index, physical activity, smoking, education, and study center. Results: The odds of new-onset asthma were increased in women who were transitional (odds ratio, 2.40; 95% CI, 1.09-5.30), early postmenopausal (odds ratio, 2.11; 95% CI,1.06-4.20), and late postmenopausal (odds ratio, 3.44; 95% CI, 1.31-9.05) at follow-up compared with nonmenopausal women. The risk of respiratory symptoms increased in early postmenopausal (coefficient, 0.40; 95% CI, 0.06-0.75) and late postmenopausal (coefficient, 0.69; 95% CI, 0.15-1.23) women. These findings were consistent irrespective of smoking status and across study centers. Conclusions: New-onset asthma and respiratory symptoms increased in women becoming postmenopausal in a longitudinal population-based study. Clinicians should be aware that respiratory health might deteriorate in women during reproductive aging. (J Allergy Clin Immunol 2016;137:50-7.)en_US
dc.rightsAttribution CC BY-NC-NDeng
dc.subjectmenopausal asthmaeng
dc.subjectrespiratory symptomseng
dc.subjectreproductive agingeng
dc.subjectRespiratory Health in Northern Europeeng
dc.subjectsex hormoneseng
dc.titleMenopause as a predictor of new-onset asthmaen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2015 the authors

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