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Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients

Ryberg, D.; Tefre, T.; Skaug, V.; Stangeland, Lodve; Øvrebø, S.; Naalsund, A.; Børresen, A.-L.; Haugen, Aa.
Peer reviewed, Journal article
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URI
https://hdl.handle.net/1956/12156
Date
1992-11
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  • Department of Clinical Science [1682]
Abstract
We have examined restriction fragment length polymorphisms of the H-ras-1 gene in germ-line DNA from 214 lung cancer patients and 309 unaffected controls. When DNA samples were digested with MspI/HpaII, Southern blot analysis revealed at least 22 different alleles, grouped according to their frequencies as common, intermediate, and rare. The frequency of rare alleles in lung cancer patients (16/428) is significantly different (p = 0.002) from that in the control group (5/618). Individuals with rare alleles were found to be at 4.7-fold greater risk of lung cancer than those with no rare alleles.
Publisher
The National Institute of Environmental Health Sciences

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