Show simple item record

dc.contributor.authorLysne, Vegarden_US
dc.contributor.authorBjørndal, Bodilen_US
dc.contributor.authorVik, Ritaen_US
dc.contributor.authorNordrehaug, Jan Eriken_US
dc.contributor.authorSkorve, Jonen_US
dc.contributor.authorNygård, Ottaren_US
dc.contributor.authorBerge, Rolf Kristianen_US
dc.PublishedNutrients 2015, 7(6):4498-4511eng
dc.description.abstractThe present study aimed to evaluate effects of a water-soluble protein fraction of chicken (CP), with a low methionine/glycine ratio, on plasma homocysteine and metabolites related to homocysteine metabolism. Male Wistar rats were fed either a control diet with 20% w/w casein as the protein source, or an experimental diet where 6, 14 or 20% w/w of the casein was replaced with the same amount of CP for four weeks. Rats fed CP had reduced plasma total homocysteine level and markedly increased levels of the choline pathway metabolites betaine, dimethylglycine, sarcosine, glycine and serine, as well as the transsulfuration pathway metabolites cystathionine and cysteine. Hepatic mRNA level of enzymes involved in homocysteine remethylation, methionine synthase and betaine-homocysteine S-methyltransferase, were unchanged, whereas cystathionine gamma-lyase of the transsulfuration pathway was increased in the CP treated rats. Plasma concentrations of vitamin B2, folate, cobalamin, and the B-6 catabolite pyridoxic acid were increased in the 20% CP-treated rats. In conclusion, the CP diet was associated with lower plasma homocysteine concentration and higher levels of serine, choline oxidation and transsulfuration metabolites compared to a casein diet. The status of related B-vitamins was also affected by CP.en_US
dc.rightsAttribution CC BYeng
dc.subjectchicken proteineng
dc.subjectone-carbon metabolismeng
dc.subjectperoxisome proliferator activated receptoreng
dc.subjectWistar ratseng
dc.titleA protein extract from chicken reduces plasma homocysteine in ratsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2015 The Authors
dc.subject.nsiVDP::Medisinske fag: 700::Helsefag: 800::Ernæring: 811
dc.subject.nsiVDP::Midical sciences: 700::Health sciences: 800::Nutrition: 811
dc.subject.nsiVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716
dc.subject.nsiVDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical immunology: 716

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution CC BY
Except where otherwise noted, this item's license is described as Attribution CC BY