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dc.contributor.authorLawrenson, Kateen_US
dc.contributor.authorLi, Qiyuanen_US
dc.contributor.authorKar, Siddharthaen_US
dc.contributor.authorSeo, Ji-Heuien_US
dc.contributor.authorTyrer, Jonathanen_US
dc.contributor.authorSpindler, Tassja J.en_US
dc.contributor.authorLee, Janeten_US
dc.contributor.authorChen, Yibuen_US
dc.contributor.authorKarst, Alisonen_US
dc.contributor.authorDrapkin, Ronnyen_US
dc.contributor.authorAben, Katja K.H.en_US
dc.contributor.authorAnton-Culver, Hodaen_US
dc.contributor.authorAntonenkova, Nataliaen_US
dc.contributor.authorBaker, Helenen_US
dc.contributor.authorBandera, Elisa V.en_US
dc.contributor.authorBean, Yukieen_US
dc.contributor.authorBeckmann, Matthias W.en_US
dc.contributor.authorBerchuck, Andrewen_US
dc.contributor.authorBisogna, Mariaen_US
dc.contributor.authorBjørge, Lineen_US
dc.contributor.authorBogdanova, Nataliaen_US
dc.contributor.authorBrinton, Louise A.en_US
dc.contributor.authorBrooks-Wilson, Angelaen_US
dc.contributor.authorBruinsma, Fionaen_US
dc.contributor.authorButzow, Ralfen_US
dc.contributor.authorCampbell, Ian G.en_US
dc.contributor.authorCarty, Karenen_US
dc.contributor.authorChang-Claude, Jennyen_US
dc.contributor.authorChenevix-Trench, Georgiaen_US
dc.contributor.authorChen, Anneen_US
dc.contributor.authorChen, Zhihuaen_US
dc.contributor.authorCook, Linda S.en_US
dc.contributor.authorCramer, Daniel W.en_US
dc.contributor.authorCunningham, Julie M.en_US
dc.contributor.authorCybulski, Cezaryen_US
dc.contributor.authorDansonka-Mieszkowska, Agnieszkaen_US
dc.contributor.authorDennis, Joeen_US
dc.contributor.authorDicks, Eden_US
dc.contributor.authorDoherty, Jennifer A.en_US
dc.contributor.authorDörk, Thiloen_US
dc.contributor.authorDu Bois, Andreasen_US
dc.contributor.authorDurst, Matthiasen_US
dc.contributor.authorEccles, Dianaen_US
dc.contributor.authorEaston, Douglas T.en_US
dc.contributor.authorEdwards, Robert P.en_US
dc.contributor.authorEilber, Ursulaen_US
dc.contributor.authorEkici, Arif B.en_US
dc.contributor.authorFasching, Peter A.en_US
dc.contributor.authorFridley, Brooke L.en_US
dc.contributor.authorGao, Yu-Tangen_US
dc.contributor.authorGentry-Maharaj, Aleksandraen_US
dc.contributor.authorGiles, Graham G.en_US
dc.contributor.authorGlasspool, Rosalinden_US
dc.contributor.authorGoode, Ellen L.en_US
dc.contributor.authorGoodman, Marc T.en_US
dc.contributor.authorGrownwald, Jaceken_US
dc.contributor.authorHarrington, Patriciaen_US
dc.contributor.authorHarter, Philippen_US
dc.contributor.authorHasmad, Hanis Nazihahen_US
dc.contributor.authorHein, Alexanderen_US
dc.contributor.authorHeitz, Florianen_US
dc.contributor.authorHildebrandt, Michelle A.T.en_US
dc.contributor.authorHillemanns, Peteren_US
dc.contributor.authorHogdall, Estriden_US
dc.contributor.authorHogdall, Clausen_US
dc.contributor.authorHosono, Satoyoen_US
dc.contributor.authorIversen, Edwin S.en_US
dc.contributor.authorJakubowska, Annaen_US
dc.contributor.authorJames, Paulen_US
dc.contributor.authorJensen, Allanen_US
dc.contributor.authorJi, Bu-Tianen_US
dc.contributor.authorKarlan, Beth Y.en_US
dc.contributor.authorKjær, Susanne Krügeren_US
dc.contributor.authorKelemen, Linda E.en_US
dc.contributor.authorKellar, Melissaen_US
dc.contributor.authorKelley, Joseph L.en_US
dc.contributor.authorKiemeney, Lambertus A.en_US
dc.contributor.authorKrakstad, Camillaen_US
dc.contributor.authorKupryjanczyk, Jolantaen_US
dc.contributor.authorLambrechts, Dietheren_US
dc.contributor.authorLambrechts, Sandrinaen_US
dc.contributor.authorLe, Nhu D.en_US
dc.contributor.authorLee, Alice W.en_US
dc.contributor.authorLele, Shashien_US
dc.contributor.authorLeminen, Artoen_US
dc.contributor.authorLester, Jennyen_US
dc.contributor.authorLevine, Douglas A.en_US
dc.contributor.authorLiang, Dongen_US
dc.contributor.authorLissowska, Jolantaen_US
dc.contributor.authorLu, Karenen_US
dc.contributor.authorLubinski, Janen_US
dc.contributor.authorLundvall, Leneen_US
dc.contributor.authorMassuger, Leon F.A.G.en_US
dc.contributor.authorMatsuo, Keitaroen_US
dc.contributor.authorMcGuire, Valerieen_US
dc.contributor.authorMcLaughlin, John R.en_US
dc.contributor.authorNevanlinna, Helien_US
dc.contributor.authorMcNeish, Ianen_US
dc.contributor.authorMenon, Ushaen_US
dc.contributor.authorModugno, Francesmaryen_US
dc.contributor.authorMoysich, Kirsten B.en_US
dc.contributor.authorNarod, Steven A.en_US
dc.contributor.authorNedergaard, Lotteen_US
dc.contributor.authorNess, Roberta B.en_US
dc.contributor.authorAzmi, Mat Adenan Nooren_US
dc.contributor.authorOdunsi, Kunleen_US
dc.contributor.authorOlson, Sara H.en_US
dc.contributor.authorOrlow, Ireneen_US
dc.contributor.authorOrsulic, Sandraen_US
dc.contributor.authorWeber, Rachel Palmierien_US
dc.contributor.authorPearce, Celeste L.en_US
dc.contributor.authorPejovic, Tanjaen_US
dc.contributor.authorPelttari, Liisa M.en_US
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dc.contributor.authorPhelan, Catherine M.en_US
dc.contributor.authorPike, Malcolm C.en_US
dc.contributor.authorPoole, Elizabeth M.en_US
dc.contributor.authorRamus, Susan J.en_US
dc.contributor.authorRisch, Harvey A.en_US
dc.contributor.authorRosen, Barryen_US
dc.contributor.authorRossing, Mary Anneen_US
dc.contributor.authorRothstein, Joseph H.en_US
dc.contributor.authorRudolph, Anjaen_US
dc.contributor.authorRunnebaum, Ingo B.en_US
dc.contributor.authorRzepecka, Iwona K.en_US
dc.contributor.authorSalvesen, Helgaen_US
dc.contributor.authorSchildkraut, Joellen Men_US
dc.contributor.authorSchwaab, Iraen_US
dc.contributor.authorSellers, Thomas A.en_US
dc.contributor.authorShu, Xiao-Ouen_US
dc.contributor.authorShvetsov, Yurii B.en_US
dc.contributor.authorSiddiqui, Nadeemen_US
dc.contributor.authorSieh, Weivaen_US
dc.contributor.authorSong, Honglinen_US
dc.contributor.authorSouthey, Melissa C.en_US
dc.contributor.authorSucheston, Laraen_US
dc.contributor.authorTangen, Ingvild Løbergen_US
dc.contributor.authorTeo, Soo-Hwangen_US
dc.contributor.authorTerry, Kathryn L.en_US
dc.contributor.authorThompson, Pamela J.en_US
dc.contributor.authorTimorek, Agnieszkaen_US
dc.contributor.authorTsai, Ya-Yuen_US
dc.contributor.authorTworoger, Shelley S.en_US
dc.contributor.authorvan Altena, Anne M.en_US
dc.contributor.authorVan Nieuwenhuysen, Elsen_US
dc.contributor.authorVergote, Ignaceen_US
dc.contributor.authorVierkant, Robert A.en_US
dc.contributor.authorWang-Gohrke, Shanen_US
dc.contributor.authorWalsh, Christineen_US
dc.contributor.authorWentzensen, Nicolasen_US
dc.contributor.authorWhittemore, Alice S.en_US
dc.contributor.authorWicklund, Kristine G.en_US
dc.contributor.authorWilkens, Lynne R.en_US
dc.contributor.authorWoo, Yin-Lingen_US
dc.contributor.authorWu, Xifengen_US
dc.contributor.authorWu, Anna H.en_US
dc.contributor.authorYang, Hannahen_US
dc.contributor.authorZheng, Weien_US
dc.contributor.authorZiogas, Argyriosen_US
dc.contributor.authorMonteiro, Alvaroen_US
dc.contributor.authorPharoah, Paul D.en_US
dc.contributor.authorGayther, Simon A.en_US
dc.contributor.authorFreedman, Matthew L.en_US
dc.contributor.authorBowtell, Daviden_US
dc.contributor.authorWebb, Penelope M.en_US
dc.contributor.authorDeFazio, Annaen_US
dc.date.accessioned2016-08-02T12:35:32Z
dc.date.available2016-08-02T12:35:32Z
dc.date.issued2015-09-22
dc.PublishedNature Communications 2015, 6:8234eng
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/1956/12394
dc.description.abstractGenome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility genes at risk loci. Here we evaluate cis-eQTL associations at 47 regions associated with HGSOC risk (P≤10−5). For three cis-eQTL associations (P<1.4 × 10−3, FDR<0.05) at 1p36 (CDC42), 1p34 (CDCA8) and 2q31 (HOXD9), we evaluate the functional role of each candidate by perturbing expression of each gene in HGSOC precursor cells. Overexpression of HOXD9 increases anchorage-independent growth, shortens population-doubling time and reduces contact inhibition. Chromosome conformation capture identifies an interaction between rs2857532 and the HOXD9 promoter, suggesting this SNP is a leading causal variant. Transcriptomic profiling after HOXD9 overexpression reveals enrichment of HGSOC risk variants within HOXD9 target genes (P=6 × 10−10 for risk variants (P<10−4) within 10 kb of a HOXD9 target gene in ovarian cells), suggesting a broader role for this network in genetic susceptibility to HGSOC.en_US
dc.language.isoengeng
dc.publisherNature Publishing Groupeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/eng
dc.titleCis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian canceren_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2016-04-11T08:46:39Z
dc.description.versionpublishedVersionen_US
dc.identifier.doihttps://doi.org/10.1038/ncomms9234
dc.identifier.cristin1282475


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