Show simple item record

dc.contributor.authorLin, Chenchen
dc.contributor.authorRajalahti, Tarja
dc.contributor.authorMjøs, Svein Are
dc.contributor.authorKvalheim, Olav Martin
dc.PublishedMetabolomics 2016, 12:6eng
dc.description.abstractA battery of methods for multivariate data analysis has been used to assess the associations between concentrations of fatty acids (FAs) and lipoprotein subclasses and particle size in serum for a normolipidemic population of ethnic Norwegians living in the rural Fjord region. Significant gender differences were found in the lipoprotein and FA patterns. Predictive FA patterns were revealed for lipoprotein features of importance for cardiovascular (CV) health. Thus, the subclasses of atherogenic small and very small low density lipoprotein (LDL) particles and the same subclasses of high density lipoprotein (HDL) particles were associated with a pattern of saturated FAs and mono-unsaturated C16-C18 FAs. Eicosapentaenoic acid (EPA) and the ratio of EPA to arachidonic acid (AA) had strongest associations to features that promotes CV health: (i) large average size of HDL and LDL particles, and, (ii) small average size of very low density lipoprotein (VLDL) particles. Total concentration of HDL in both genders correlated to EPA, but docosahexaenoic acid (DHA) correlated just as strongly for women. For men, docosapentaenoic acid (DPA) showed stronger association to HDL concentration than EPA. For both genders, concentration of large LDL particles showed associations to levels of EPA, but stronger to DHA and DPA. High values of EPA/AA seem to be the strongest single biomarker for good CV health in both men and women.en_US
dc.rightsAttribution CC BYeng
dc.subjectHuman serumeng
dc.subjectLipoprotein subclasseseng
dc.subjectPolyunsaturated fatty acids (PUFAs)eng
dc.subjectRatio of eicasapentaenoic acid (EPA) to arachidonic acid (AA)eng
dc.subjectDocosahexaenoic acid (DHA)eng
dc.subjectSelectivity ratioeng
dc.titlePredictive associations between serum fatty acids and lipoproteins in healthy non-obese Norwegians: implications for cardiovascular healthen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2015 The Authorsen_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution CC BY
Except where otherwise noted, this item's license is described as Attribution CC BY