• Advanced Free Energy Methods in Retrospective and Prospective Drug Design: Application to Serine Proteases 

  Gartan, Parveen (Doctoral thesis, 2024-12-13)

  Beregninger av relativ fri bindingsenergi (eng. RBFE) har vokst frem som en foretrukket metode for å veilede kostbare og tidkrevende synteser og andre eksperimenter i legemiddelutvikling på grunn av metodens nærmest ...

• Exposure of Polycyclic Aromatic Hydrocarbons (PAHs) and Crude Oil to Atlantic Haddock (Melanogrammus aeglefinus): A Unique Snapshot of the Mercapturic Acid Pathway 

  Nakken, Charlotte Langeland; Berntssen, Marc HG; Meier, Sonnich; Bijlsma, Lubertus; Mjøs, Svein Are; Sørhus, Elin; Donald, Carey (Journal article; Peer reviewed, 2024)

  Fish exposed to xenobiotics like petroleum-derived polycyclic aromatic hydrocarbons (PAHs) will immediately initiate detoxification systems through effective biotransformation reactions. Yet, there is a discrepancy between ...

• Advancing Discovery of Polar Polycyclic Aromatic Hydrocarbons via UHPLC-HRMS 

  Nakken, Charlotte Langeland (Doctoral thesis, 2024-11-29)

  Industrielle utslipp fra offshore petroleumsvirksomhet introduserer polysykliske aromatiske hydrokarboner (PAH-er) i marine miljøer. Miljøovervåkning av petroleum-relaterte PAH-er i fisk innebærer måling av et sett av deres ...

• Redesigning Clozapine : Development of Clozapine Analogues for the Potential Treatment of Melanoma Brain Metastases 

  Barranco Campos, Sara (Doctoral thesis, 2024-11-22)

  Kreft er den nest vanligste dødsårsaken i Europa. Mangelen på selektiviteten mellom vev danner bivirkninger, uavhengig om behandlingstype. Utvikling av nye behandlinger kan ta opptil 15 år og er kostbart. Gjenbruk av ...

• Exploring the Potential of Biomass Resources Available in Western Norway 

  Herdlevær, Kristoffer Mega (Doctoral thesis, 2024-10-21)

  Fornybare energikilder som vind, sol, vannkraft og geotermisk energi kan bidra til å erstatte fossile ressurser for å dekke et energibehov, men de kan ikke erstatte vanlig brukte fossilbaserte kjemiske produkter og ...

• Optimizing Formic Acid-Assisted Co-HTL of Digested Sewage Sludge and Lignocellulosic Waste for Enhanced Bio-Crude Yield and Energy Recovery 

  Herdlevær, Kristoffer Mega; Barth, Tanja (Journal article; Peer reviewed, 2024)

  In recent years, hydrothermal liquefaction (HTL) has gained attention as a means of enhancing and increasing the production of biofuels from biomass. Co-HTL involves the simultaneous processing of two or more feedstocks, ...

• Extracellular vesicles for breast cancer diagnosis and therapy 

  Shi, Jianan; Zhang, Huan; Cui, Yaxin; Xing, Jianming; Wang, Wei; Chen, Jiayi; Wang, Simiao; Yang, Zhaogang (Journal article, 2024)

  Breast cancer is still suffering from its poor diagnosis and the lack of effective treatment. Despite of recent development of some novel chemicals, which are found to have inspiring therapeutic effects in vitro, their ...

• Thermal stability of polyphenols and carotenoids from Laminaria hyperborea 

  Johannesen, Benjamin Alexander (Master thesis, 2024-06-03)

  The green shift, and the focus on an increased blue bioeconomy, has stimulated the growth of sustainable production lines for marine bioactive products for food-, feed-, cosmetics-, and -pharmaceutical industries. Norway ...

• Exploring gas adsorption properties and phase transitions of two M(tppo) metal-organic frameworks 

  Brun, Julie (Master thesis, 2024-06-03)

  Separation and storage of gases is of interest to the global society in order to minimize emission of greenhouse gases and utilize these gases as resources in their pure form in the chemical industry. This work considers ...

• Videregående elevers opplevelse av mappevurdering i naturfag 

  Gjesholm, Johanne; Røren, Elise Marie Mallasvik (Master thesis, 2024-06-03)

  Vurdering er en sentral del i utdanningen i den norske skolen. Gjennom den nye læreplanen er det et mål å legge til rette for blant annet dybdelæring og aktiv læring. Dermed blir det viktig at elevene får utføre utforskende ...

• Qualitative and quantitative analyses of unbound phenolic compounds from pollen grains of pine (Pinus uncinata) 

  Vikestad, Kajsa Vikøren (Master thesis, 2024-06-03)

  The research in this master project is performed within an interdisciplinary RCN (The Research Council of Norway) research project (QUEST-UV: Quantitative estimates of past UV-B irradiance from fossil pollen) and includes ...

• Investigating the Impact of Fermentation on Polyphenolic Content in Cultivated Sugar Kelp (Saccharina latissima): A Comprehensive Study 

  Heggenes, Eva Bergit (Master thesis, 2024-06-03)

  Seaweeds, classified as macroalgae, are a marine bioresource garnering global attention, primarily due to the increasing demand for new sustainable bioresources. Seaweeds are rich in a variety of bioactive compounds that ...

• Source and fate of ultra-short-chain PFAS in AFFF-impacted water and biota 

  Sture, Magnus (Master thesis, 2024-06-24)

• Adapting CoRe and Storyline as tools to promote learning and coherence in a chemistry education course 

  Stadler, Matthias Gregor (Research report, 2023)

• Biological Evaluations, NMR Analyses, Molecular Modeling Studies, and Overview of the Synthesis of the Marine Natural Product (−)-Mucosin 

  Nolsøe, Jens Mortansson Jelstrup; Underhaug, Jarl; Sørskår, Åshild Moi; Antonsen, Simen; Malterud, Karl Egil; Gani, Osman; Fan, Qiong; Hjorth, Marit; Sæther, Thomas; Hansen, Trond Vidar; H. Stenstrøm, Yngve (Journal article; Peer reviewed, 2024)

  Natural products obtained from marine organisms continue to be a rich source of novel structural architecture and of importance in drug discovery, medicine, and health. However, the success of such endeavors depends on the ...

• Charge Transfer Quenching and Maximum of a Liquid-Air Contact Line Moving over a Hydrophobic Surface 

  Helseth, Lars Egil (Journal article; Peer reviewed, 2024)

  Charge transfer when a hydrophobic fluoropolymer surface comes in contact with salt solutions of water, methanol, and glycerol is investigated. It is found that the charge transfer decreases faster with an increasing ...

• Biodistribution of Therapeutic Nanoparticles in Zebrafish Larvae 

  Roald, Ole-Martin Heggem (Master thesis, 2024-06-03)

• Investigating Polypharmacology through Targeting Known Human Neutrophil Elastase Inhibitors to Proteinase 3 

  Gartan, Parveen; Khorsand, Fahimeh; Mizar, Pushpak; Vahokoski, Juha; Cervantes, Luis F.; Haug, Bengt Erik; Brenk, Ruth; Brooks, Charles L.; Reuter, Nathalie (Journal article; Peer reviewed, 2024)

  Using a combination of multisite λ−dynamics (MSλD) together with in vitro IC50 assays, we evaluated the polypharmacological potential of a scaffold currently in clinical trials for inhibition of human neutrophil elastase ...

• Tissue accumulation of polystyrene microplastics causes oxidative stress, hepatopancreatic injury and metabolome alterations in Litopenaeus vannamei 

  Zeng, Yingxu; Deng, Baichuan; Kang, Zixin; Araujo, Pedro; Mjøs, Svein Are; Lin, Jianhui; Liu, Ruina; Yang, Tao; Qu, Yuangao (Journal article; Peer reviewed, 2023)

  Microplastics (MPs) pose one of the major environmental threats to marine organisms and ecosystems on a global scale. Although many marine crustaceans are highly susceptible to MPs pollution, the toxicological effects and ...

• Discovery of polycyclic aromatic acid metabolites in fish exposed to the petroleum compounds 1-methylphenanthrene and 1,4-dimethylphenanthrene 

  Nakken, Charlotte Langeland; Meier, Sonnich; Mjøs, Svein Are; Bijlsma, Lubertus; Rowland, Steven J; Donald, Carey (Journal article; Peer reviewed, 2024)

  Most of the polycyclic aromatic hydrocarbons (PAHs) in petroleum are alkylated (alkyl PAHs), still the metabolism of these alkyl PAHs to the expected acid products (polycyclic aromatic acids; PAAs) has yet to be demonstrated ...

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