• Relative Spatial Positions of Tryptophan and Cationic Residues in Helical Membrane-active Peptides Determine Their Cytotoxicity 

  Rekdal, Øystein; Haug, Bengt Erik; Kalaaji, manar; Hunter, Howard N.; Lindin, Inger; Israelsson, Ingrid; Solstad, Terese; Yang, Nannan; Brandl, Martin; Mantzilas, Dimitrios; Vogel, Hans J. (Journal article; Peer reviewed, 2012)

  The cytotoxic activity of 10 analogs of the idealized amphipathic helical 21-mer peptide (KAAKKAA)3, where three of the Ala residues at different positions have been replaced with Trp residues, has been investigated. The ...

• Application of Antisolvent Precipitation Method for Formulating Excipient-Free Nanoparticles of Psychotropic Drugs 

  Wu, Carina; Wang, Wei (Journal article; Peer reviewed, 2022)

  The aim of the present study was to systematically examine the effects of variations in the process parameters of the antisolvent precipitation method employed in the preparation of excipient-free pure nanoparticles of ...

• A Scalable High-Yielding and Selective Oxidative Heck Cross-Coupling – A Key Step for the Synthesis of trans- Stilbenes 

  Cirillo, Davide; Karlsson, Staffan; Bjørsvik, Hans-René (Journal article; Peer reviewed, 2021)

  A selective oxidative Heck cross-coupling method was developed and optimized as a pivotal step for a synthetic route leading to the trans-stilbene framework. The developed method and synthesis were needed in a SAR study ...

• Short and Modular Synthesis of Substituted 2‑Aminopyrroles 

  Diana-Rivero, Raquel; Halsvik, Beate; Garciá Tellado, Fernando; Tejedor, David (Journal article; Peer reviewed, 2021)

  We herein describe a simple and metal-free domino methodology to synthesize 2-aminopyrroles from alkynyl vinyl hydrazides. The domino reaction involves a novel propargylic 3,4-diaza-Cope rearrangement and a tandem ...

• Membrane models for molecular simulations of peripheral membrane proteins 

  Moqadam, Mahmoud; Tubiana, Thibault Michel Joseph; Moutoussamy, Emmanuel Edouard; Reuter, Nathalie (Journal article; Peer reviewed, 2021)

  Peripheral membrane proteins (PMPs) bind temporarily to the surface of biological membranes. They also exist in a soluble form and their tertiary structure is often known. Yet, their membrane-bound form and their ...

• Bis(Phenolate)-Functionalized N-Heterocyclic Carbene Complexes of Oxo- and Imido-Vanadium(V) 

  Suresh, Lakshmi; Finnestad, Jone; Törnroos, Karl Wilhelm; Le Roux, Erwan (Journal article; Peer reviewed, 2021)

  Oxo- and imido-vanadium(V) metal complexes supported by bis(phenolate)-functionalized N-heterocyclic carbene (NHC) ligands were synthesized and structurally identified. In the presence of [(Ph3P=)2N]Cl ([PPN]Cl), saturated ...

• Computational Applications in Secondary Metabolite Discovery (CAiSMD): an online workshop 

  Ntie-Kang, Fidele; Telukunta, Kiran K.; Fobofou, Serge A. T.; Chukwudi Osamor, Victor; Egieyeh, Samuel A.; Valli, Marilia; Djoumbou-Feunang, Yannick; Sorokina, Maria; Stork, Conrad; Mathai, Neann Sarah; Zierep, Paul; Chávez-Hernández, Ana L.; Duran-Frigola, Miquel; Babiaka, Smith B.; Tematio Fouedjou, Romuald; Eni, Donatus B.; Akame, Simeon; Arreyetta-Bawak, Augustine B.; Ebob, Oyere T.; Metuge, Jonathan A.; Bekono, Boris D.; Isa, Mustafa A.; Onuku, Raphael; Shadrack, Daniel M.; Musyoka, Thommas M.; Patil, Vaishali M.; van der Hooft, Justin J. J.; da Silva Bolzani, Vanderlan; Medina-Franco, José L.; Kirchmair, Johannes; Weber, Tilmann; Tastan Bishop, Özlem; Medema, Marnix H.; Wessjohann, Ludger A.; Ludwig-Müller, Jutta (Journal article; Peer reviewed, 2021-09-06)

  We report the major conclusions of the online open-access workshop “Computational Applications in Secondary Metabolite Discovery (CAiSMD)” that took place from 08 to 10 March 2021. Invited speakers from academia and industry ...

• Diels-Alder reactions with 1,1-diethoxybut-3-yn-2-one and some 1,1-diethoxy-5-hydroxyalk-3-yn-2-ones and their acetates 

  Hansen, Frank; Sydnes, Leiv K. (Journal article; Peer reviewed, 2020)

• The Impact of Rheology on Viscous Oil Displacement by Polymers Analyzed by Pore-Scale Network Modelling 

  Salmo, Iselin Cecilie; Sorbie, Ken; Skauge, Arne (Journal article; Peer reviewed, 2021)

  Several experimental studies have shown significant improvement in heavy oil recovery with polymers displaying different types of rheology, and the effect of rheology has been shown to be important. These experimental ...

• Predicting the Skin Sensitization Potential of Small Molecules with Machine Learning Models Trained on Biologically Meaningful Descriptors 

  Wilm, Anke; Garcia de Lomana, Marina; Stork, Conrad; Mathai, Neann Sarah; Hirte, Steffen; Norinder, Ulf; Kühl, Jochen; Kirchmair, Johannes (Journal article; Peer reviewed, 2021)

  In recent years, a number of machine learning models for the prediction of the skin sensitization potential of small organic molecules have been reported and become available. These models generally perform well within ...

• Routes to High-Performing Ruthenium–Iodide Catalysts for Olefin Metathesis: Ligand Lability Is Key to Efficient Halide Exchange 

  Blanco, Christian O.; Nascimento, Daniel L.; Fogg, Deryn Elizabeth (Journal article; Peer reviewed, 2021)

  Clean, high-yielding routes are described to ruthenium–diiodide catalysts that were recently shown to enable high productivity in olefin metathesis. For the second-generation Grubbs and Hoveyda catalysts (GII: RuCl2(H2IM ...

• The Impact of Water on Ru-Catalyzed Olefin Metathesis: Potent Deactivating Effects Even at Low Water Concentrations 

  Blanco, Christian O.; Sims, Joshua; Nascimento, Daniel L.; Goudreault, Alexandre Y.; Steinmann, Stephan N.; Michel, Carine; Fogg, Deryn Elizabeth (Journal article; Peer reviewed, 2021)

  Ruthenium catalysts for olefin metathesis are widely viewed as water-tolerant. Evidence is presented, however, that even low concentrations of water cause catalyst decomposition, severely degrading yields. Of 11 catalysts ...

• Cellulose‑g‑tetraethylenepentamine dual‑function imprinted polymers selectively and efectively adsorb and remove 4‑nitrophenol and Cr(VI) 

  Lang, Daning; Xu, Xia; Wu, Ronglan; Wang, Wei; Shi, Ming; Jia, Ke; Chen, Shifei; Wang, Jide (Journal article; Peer reviewed, 2022)

  A cellulosic material has been synthesized that could efficiently and selectively adsorb organic and inorganic contaminants from aqueous solutions without interference from competing adsorption sites. Cellulose-graft-tet ...

• Development of Endothelial Barrier Models for Nanotoxicity Testing 

  Nalliah, Medhusja Sritharan (Master thesis, 2022-02-07)

  Nanotechnology is a field of both research and innovation that is ever-growing. It Is the study and manipulation of matter at the nanoscale to produce materials and devices with enhanced properties. Industries are spending ...

• Energetic and Exergetic Performances of a Retrofitted, Large-Scale, Biomass-Fired CHP Coupled to a Steam-Explosion Biomass Upgrading Plant, a Biorefinery Process and a High-Temperature Heat Network 

  De Meulenaere, Roeland; Maertens, Tim; Sikkema, Ale; Brusletto, Rune; Barth, Tanja; Blondeau, Julien (Journal article; Peer reviewed, 2021)

  This paper aims at assessing the impact of retrofitting an existing, 730 MWe, coal-fired power plant into a biomass-fired combined heat and power (CHP) plant on its energetic and exergetic performances. A comprehensive ...

• A Workup Protocol Combined with Direct Application of Quantitative Nuclear Magnetic Resonance Spectroscopy of Aqueous Samples from Large-Scale Steam Explosion of Biomass 

  Løhre, Camilla; Underhaug, Jarl; Brusletto, Rune; Barth, Tanja (Journal article; Peer reviewed, 2021)

  Methods for thermochemical conversion of biomass into renewable energy and materials rapidly increase in range and outreach. A focus on the target product streams for valorization is natural, yet several pretreatment steps ...

• Promoting Coherent Science Instruction through Coherent Science Teacher Education: A Model Framework for Program Design 

  Nordine, Jeffrey; Sorge, Stefan; Delen, Ibrahim; Evans, Robert; juuti, kalle; Lavonen, Jari; Nilsson, Pernilla; Ropohl, Mathias; Stadler, Matthias Gregor (Journal article; Peer reviewed, 2021)

  Recent research and reform efforts in science education have consistently stressed the importance of coherent science instruction, in which learning opportunities are connected and contextualized by meaningful phenomena, ...

• Structure-Activity-Relationship-Aided Design and Synthesis of xCT Antiporter Inhibitors 

  Cirillo, Davide; Sarowar, Shahin; Enger, Per Øyvind; Bjørsvik, Hans-René (Journal article; Peer reviewed, 2021)

  The xCT antiporter is a cell membrane protein involved in active counter-transportation of glutamate (outflux) with cystine (influx) over the human cell membrane. This feature makes the xCT antiporter a crucial element of ...

• Rapid Landscape Changes in Plastic Bays Along the Norwegian Coastline 

  Bastesen, Eivind; Haave, Marte; Andersen, Gidske Leknæs; Velle, Gaute; Bødtker, Gunhild; Krafft, Charlotte Gannefors (Journal article; Peer reviewed, 2021)

  The Norwegian Coastal Current transports natural debris and plastic waste along the Norwegian coastline. Deposition occurs in so-called wreck-bays and includes floating debris, such as seaweed, driftwood and volcanic pumice, ...

• Influence of adiposity and physical activity on the cardiometabolic association pattern of lipoprotein subclasses to aerobic fitness in prepubertal children 

  Rajalahti, Tarja; Aadland, Eivind; Resaland, Geir Kåre; Anderssen, Sigmund Alfred; Kvalheim, Olav Martin (Journal article; Peer reviewed, 2021)

  Aerobic fitness (AF) and lipoprotein subclasses associate to each other and to cardiovascular health. Adiposity and physical activity (PA) influence the association pattern of AF to lipoproteins almost inversely making it ...

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