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dc.contributor.authorSørhus, Elin
dc.contributor.authorIncardona, John P.
dc.contributor.authorKarlsen, Ørjan
dc.contributor.authorLinbo, Tiffany
dc.contributor.authorSørensen, Lisbet
dc.contributor.authorNordtug, Trond
dc.contributor.authorvan der Meeren, Terje
dc.contributor.authorThorsen, Anders
dc.contributor.authorThorbjørnsen, Maja
dc.contributor.authorJentoft, Sissel
dc.contributor.authorEdvardsen, Rolf
dc.contributor.authorMeier, Sonnich
dc.PublishedScientific Reports 2016, 6:31058eng
dc.description.abstractRecent studies have shown that crude oil exposure affects cardiac development in fish by disrupting excitation-contraction (EC) coupling. We previously found that eggs of Atlantic haddock (Melanogrammus aeglefinus) bind dispersed oil droplets, potentially leading to more profound toxic effects from uptake of polycyclic aromatic hydrocarbons (PAHs). Using lower concentrations of dispersed crude oil (0.7–7 μg/L ∑PAH), here we exposed a broader range of developmental stages over both short and prolonged durations. We quantified effects on cardiac function and morphogenesis, characterized novel craniofacial defects, and examined the expression of genes encoding potential targets underlying cardiac and craniofacial defects. Because of oil droplet binding, a 24-hr exposure was sufficient to create severe cardiac and craniofacial abnormalities. The specific nature of the craniofacial abnormalities suggests that crude oil may target common craniofacial and cardiac precursor cells either directly or indirectly by affecting ion channels and intracellular calcium in particular. Furthermore, down-regulation of genes encoding specific components of the EC coupling machinery suggests that crude oil disrupts excitation-transcription coupling or normal feedback regulation of ion channels blocked by PAHs. These data support a unifying hypothesis whereby depletion of intracellular calcium pools by crude oil-derived PAHs disrupts several pathways critical for organogenesis in fish.en_US
dc.publisherNature Publishing Groupen_US
dc.rightsAttribution CC BYeng
dc.titleCrude oil exposures reveal roles for intracellular calcium cycling in haddock craniofacial and cardiac developmenten_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright The Author(s) 2016en_US
dc.relation.projectNorges forskningsråd: 234367
dc.subject.nsiVDP::Matematikk og naturvitenskap: 400::Zoologiske og botaniske fag: 480::Marinbiologi: 497
dc.subject.nsiVDP::Mathematics and natural scienses: 400::Zoology and botany: 480::Marine biology: 497
dc.subject.nsiVDP::Matematikk og naturvitenskap: 400::Kjemi: 440::Miljøkjemi, naturmiljøkjemi: 446
dc.subject.nsiVDP::Mathematics and natural scienses: 400::Chemistry: 440::Environmental chemistry, natural environmental chemistry: 446

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Attribution CC BY
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