dc.contributor.author | Monsen, Anne Lise Bjørke | en_US |
dc.contributor.author | Ulvik, Arve | en_US |
dc.contributor.author | Nilsen, Roy Miodini | en_US |
dc.contributor.author | Midttun, Øivind | en_US |
dc.contributor.author | Roth, Christine | en_US |
dc.contributor.author | Magnus, Per | en_US |
dc.contributor.author | Stoltenberg, Camilla | en_US |
dc.contributor.author | Vollset, Stein Emil | en_US |
dc.contributor.author | Reichborn-Kjennerud, Ted | en_US |
dc.contributor.author | Ueland, Per Magne | en_US |
dc.date.accessioned | 2017-05-04T11:34:07Z | |
dc.date.available | 2017-05-04T11:34:07Z | |
dc.date.issued | 2016-11-30 | |
dc.Published | Monsen ALB, Ulvik A, Nilsen RM, Midttun Ø, Roth C, Magnus P, Stoltenberg C, Vollset SE, Reichborn-Kjennerud T, Ueland PM. Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study . Nutrients. 2016;8(12):776 | eng |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | https://hdl.handle.net/1956/15775 | |
dc.description.abstract | Maternal nutrition and inflammation have been suggested as mediators in the development of various adverse pregnancy outcomes associated with maternal obesity. We have investigated the relation between pre-pregnancy BMI, B vitamin status, and inflammatory markers in a group of healthy pregnant women. Cobalamin, folate, pyridoxal 5'-phosphate, and riboflavin; and the metabolic markers homocysteine, methylmalonic acid, and 3-hydroxykynurenine/xanthurenic acid ratio (HK/XA); and markers of cellular inflammation, neopterin and kynurenine/tryptophan ratio (KTR) were determined in pregnancy week 18 and related to pre-pregnancy body mass index (BMI), in 2797 women from the Norwegian Mother and Child Cohort Study (MoBa). Pre-pregnancy BMI was inversely related to folate, cobalamin, pyridoxal 5'-phosphate (PLP), and riboflavin (p < 0.001), and associated with increased neopterin and KTR levels (p < 0.001). Inflammation seemed to be an independent predictor of low vitamin B6 status, as verified by low PLP and high HK/XA ratio. A high pre-pregnancy BMI is a risk factor for low B vitamin status and increased cellular inflammation. As an optimal micronutrient status is vital for normal fetal development, the observed lower B vitamin levels may contribute to adverse pregnancy outcomes associated with maternal obesity and B vitamin status should be assessed in women with high BMI before they get pregnant. | en_US |
dc.language.iso | eng | eng |
dc.publisher | MDPI | eng |
dc.relation.uri | http://www.mdpi.com/2072-6643/8/12/776 | |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0 | eng |
dc.subject | Pregnancy | eng |
dc.subject | Obesity | eng |
dc.subject | pre-pregnancy BMI | eng |
dc.subject | B vitamins | eng |
dc.subject | Inflammation | eng |
dc.title | Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2017-01-30T11:48:13Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2016 The Author(s) | |
dc.identifier.doi | https://doi.org/10.3390/nu8120776 | |
dc.identifier.cristin | 1421656 | |
dc.source.journal | Nutrients | |