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dc.contributor.authorMonsen, Anne Lise Bjørkeen_US
dc.contributor.authorUlvik, Arveen_US
dc.contributor.authorNilsen, Roy Miodinien_US
dc.contributor.authorMidttun, Øivinden_US
dc.contributor.authorRoth, Christineen_US
dc.contributor.authorMagnus, Peren_US
dc.contributor.authorStoltenberg, Camillaen_US
dc.contributor.authorVollset, Stein Emilen_US
dc.contributor.authorReichborn-Kjennerud, Teden_US
dc.contributor.authorUeland, Per Magneen_US
dc.PublishedMonsen ALB, Ulvik A, Nilsen RM, Midttun Ø, Roth C, Magnus P, Stoltenberg C, Vollset SE, Reichborn-Kjennerud T, Ueland PM. Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study . Nutrients. 2016;8(12):776eng
dc.description.abstractMaternal nutrition and inflammation have been suggested as mediators in the development of various adverse pregnancy outcomes associated with maternal obesity. We have investigated the relation between pre-pregnancy BMI, B vitamin status, and inflammatory markers in a group of healthy pregnant women. Cobalamin, folate, pyridoxal 5'-phosphate, and riboflavin; and the metabolic markers homocysteine, methylmalonic acid, and 3-hydroxykynurenine/xanthurenic acid ratio (HK/XA); and markers of cellular inflammation, neopterin and kynurenine/tryptophan ratio (KTR) were determined in pregnancy week 18 and related to pre-pregnancy body mass index (BMI), in 2797 women from the Norwegian Mother and Child Cohort Study (MoBa). Pre-pregnancy BMI was inversely related to folate, cobalamin, pyridoxal 5'-phosphate (PLP), and riboflavin (p < 0.001), and associated with increased neopterin and KTR levels (p < 0.001). Inflammation seemed to be an independent predictor of low vitamin B6 status, as verified by low PLP and high HK/XA ratio. A high pre-pregnancy BMI is a risk factor for low B vitamin status and increased cellular inflammation. As an optimal micronutrient status is vital for normal fetal development, the observed lower B vitamin levels may contribute to adverse pregnancy outcomes associated with maternal obesity and B vitamin status should be assessed in women with high BMI before they get pregnant.en_US
dc.rightsAttribution CC BYeng
dc.subjectpre-pregnancy BMIeng
dc.subjectB vitaminseng
dc.titleImpact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Studyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2016 The Author(s)

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