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dc.contributor.authorSøreide, Jon Arneen_US
dc.contributor.authorUndersrud, Erling Sandøyen_US
dc.contributor.authorAl-Saiddi, Mohammeden_US
dc.contributor.authorTholfsen, Toreen_US
dc.contributor.authorSøreide, Kjetilen_US
dc.PublishedSøreide JA, et al. Primary Leiomyosarcoma of the Pancreas—a Case Report and a Comprehensive Review. Journal of Gastrointestinal Cancer. 2016;47:358-365eng
dc.description.abstractPurpose: Primary mesenchymal tumors of the pancreas are rare, with leiomyosarcomas the most encountered entities among the pancreatic sarcomas. With few exceptions, single case reports published over the last six decades constitute the entire scientific literature on this topic. Thus, evidence regarding clinical decision-making is scant. Methods: Based on a case report and an extensive literature search in PubMed, we discuss the clinical aspects and current management of this rare malignancy. Results: We identified only two papers with more than a single case presentation; these institutional patient series were limited to five and nine patients. Additionally, a few papers sought to summarize the individual case reports published in the English and/or Chinese language. The clinical presentation is rather non-specific. Moreover, modern imaging modalities are insufficiently accurate to diagnose leiomyosarcoma of the pancreas. Treatment goals include a complete resection with free margins. Proper morphologic examination using immunohistochemistry and the application of a grading system are clinically important for prognostication. The efficacy of adjuvant treatments has not been established. Conclusion: Primary pancreatic leiomyosarcoma is extremely rare, and the scientific literature is primarily based on single case reports. Conclusions on management and prognosis should be drawn with caution. A multidisciplinary team consultation is warranted to discuss a thorough individual treatment plan based on the available scientific literature, despite its low evidence level.en_US
dc.rightsAttribution CC BYeng
dc.subjectMesenchymal tumoreng
dc.titlePrimary Leiomyosarcoma of the Pancreas—a Case Report and a Comprehensive Reviewen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2016 The Author(s)
dc.source.journalJournal of Gastrointestinal Cancer

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