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dc.contributor.authorMehl, Arneen_US
dc.contributor.authorÅsvold, Bjørn Olaven_US
dc.contributor.authorKümmel, Angelaen_US
dc.contributor.authorLydersen, Stianen_US
dc.contributor.authorPaulsen, Julieen_US
dc.contributor.authorHaugan, Ingvilden_US
dc.contributor.authorSolligård, Eriken_US
dc.contributor.authorDamås, Jan Kristianen_US
dc.contributor.authorHarthug, Stigen_US
dc.contributor.authorEdna, Tom-Haralden_US
dc.PublishedMehl A, Åsvold BO, Kümmel A, Lydersen S, Paulsen J, Haugan, Solligård E, Damås JK, Harthug S, Edna T-H. Trends in antimicrobial resistance and empiric antibiotic therapy of bloodstream infections at a general hospital in Mid-Norway: A prospective observational study. BMC Infectious Diseases. 2017;17:116eng
dc.description.abstractBackground: The occurrence of bloodstream infection (BSI) and antimicrobial resistance have been increasing in many countries. We studied trends in antimicrobial resistance and empiric antibiotic therapy at a medium-sized general hospital in Mid-Norway. Methods: Between 2002 and 2013, 1995 prospectively recorded episodes of BSI in 1719 patients aged 16–99 years were included. We analyzed the antimicrobial non-susceptibility according to place of acquisition, site of infection, microbe group, and time period. Results: There were 934 community-acquired (CA), 787 health care-associated (HCA) and 274 hospital-acquired (HA) BSIs. The urinary tract was the most common site of infection. Escherichia coli was the most frequently isolated infective agent in all three places of acquisition. Second in frequency was Streptococcus pneumoniae in CA and Staphylococcus aureus in both HCA and HA. Of the BSI microbes, 3.5% were non-susceptible to the antimicrobial regimen recommended by the National Professional Guidelines for Use of Antibiotics in Hospitals, consisting of penicillin, gentamicin, and metronidazole (PGM). In contrast, 17.8% of the BSI microbes were non-susceptible to cefotaxime and 27.8% were non-susceptible to ceftazidime. Antimicrobial non-susceptibility differed by place of acquisition. For the PGM regimen, the proportions of non-susceptibility were 1.4% in CA, 4.8% in HCA, and 6.9% in HA-BSI (p < 0.001), and increasing proportions of non-susceptibility over time were observed in HA-BSI, 2.2% in 2002–2005, 6.2% in 2006–2009, and 11.7% in 2010–2013 (p = 0.026), mainly caused by inherently resistant microbes. We also observed increasing numbers of bacteria with acquired resistance, particularly E. coli producing ESBL or possessing gentamicin resistance, and these occurred predominantly in CA- and HCA-BSI. Conclusions: Generally, antimicrobial resistance was a far smaller problem in our BSI cohort than is reported from countries outside Scandinavia. In our cohort, appropriate empiric antibiotic therapy could be achieved to a larger extent by replacing second- and third-generation cephalosporins with penicillin-gentamicin or piperacillin-tazobactam.en_US
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.subjectAntibiotic therapyeng
dc.subjectAntimicrobial resistanceeng
dc.subjectBloodstream infectioneng
dc.subjectEmpiric antibiotic treatmenteng
dc.titleTrends in antimicrobial resistance and empiric antibiotic therapy of bloodstream infections at a general hospital in Mid-Norway: A prospective observational studyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2017 The Author(s)
dc.source.journalBMC Infectious Diseases

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