dc.contributor.author | Øygarden, Halvor | en_US |
dc.contributor.author | Fromm, Annette | en_US |
dc.contributor.author | Sand, Kristin Modalsli | en_US |
dc.contributor.author | Kvistad, Christopher Elnan | en_US |
dc.contributor.author | Eide, Geir Egil | en_US |
dc.contributor.author | Thomassen, Lars | en_US |
dc.contributor.author | Næss, Halvor | en_US |
dc.contributor.author | Waje-Andreassen, Ulrike | en_US |
dc.date.accessioned | 2017-12-18T11:21:39Z | |
dc.date.available | 2017-12-18T11:21:39Z | |
dc.date.issued | 2016-08-09 | |
dc.Published | Øygarden H, Fromm A, Sand KM, Kvistad CE, Eide GE, Thomassen L, Næss H, Waje-Andreassen U. A family history of stroke is associated with increased intima-media thickness in young ischemic Stroke - The norwegian stroke in the young study (NOR-SYS). PLoS ONE. 2016;11(8):e0159811 | eng |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://hdl.handle.net/1956/17006 | |
dc.description.abstract | Background and Purpose: Positive family history (FH+) of cardiovascular disease (CVD) is a risk factor for own CVD. We aimed to analyze the effect of different types of FH (stroke, coronary heart disease (CHD), peripheral artery disease (PAD) on carotid intima-media thickness (cIMT) in young and middle-aged ischemic stroke patients. Methods: First-degree FH of CVD was assessed in ischemic stroke patients ≤ 60y using a standardized interview. Carotid ultrasound was performed and far wall cIMT in three carotid artery segments was registered, representing the common carotid (CCA-IMT), carotid bifurcation (BIF-IMT) and the internal carotid artery (ICA-IMT). Measurements were compared between FH+ and FH negative groups and stepwise backward regression analyses were performed to identify factors associated with increased cIMT. Results: During the study period 382 patients were enrolled, of which 262 (68%) were males and 233 (61%) reported FH of CVD. Regression analyses adjusting for risk factors revealed age as the most important predictor of cIMT in all segments. The association between FH+ and cIMT was modified by age (p = 0.014) and was significant only regarding ICA-IMT. FH+ was associated with increased ICA-IMT in patients aged < 45y (p = 0.001), but not in patients ≥ 45y (p = 0.083). The association with ICA-IMT was present for a FH of stroke (p = 0.034), but not a FH+ of CHD or PAD. Conclusions: FH of stroke is associated with higher ICA-IMT in young ischemic stroke patients. Subtyping of cardiovascular FH is important to investigate heredity in young ischemic stroke patients. | en_US |
dc.language.iso | eng | eng |
dc.publisher | PLOS | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0 | eng |
dc.title | A family history of stroke is associated with increased intima-media thickness in young ischemic Stroke - The norwegian stroke in the young study (NOR-SYS) | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2017-12-05T12:23:33Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2016 The Author(s) | |
dc.identifier.doi | https://doi.org/10.1371/journal.pone.0159811 | |
dc.identifier.cristin | 1392751 | |
dc.source.journal | PLoS ONE | |