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dc.contributor.authorSmeland, Olav Bjerkehagenen_US
dc.contributor.authorWang, Yunpengen_US
dc.contributor.authorLo, Min-Tzuen_US
dc.contributor.authorLi, Wenen_US
dc.contributor.authorFrei, Oleksandren_US
dc.contributor.authorWitoelar, Areeen_US
dc.contributor.authorTesli, Martin Steenen_US
dc.contributor.authorHinds, David A.en_US
dc.contributor.authorTung, Joyce Y.en_US
dc.contributor.authorDjurovic, Srdjanen_US
dc.contributor.authorChen, Chi-Huaen_US
dc.contributor.authorDale, Andersen_US
dc.contributor.authorAndreassen, Ole Andreasen_US
dc.PublishedSmeland OB, Wang Y, Lo M, Li W, Frei O, Witoelar AW, Tesli MS, Hinds DA, Tung JY, Djurovic S, Chen C, Dale A, Andreassen OA. Identification of genetic loci shared between schizophrenia and the Big Five personality traits. Scientific Reports. 2017;7:2222eng
dc.description.abstractSchizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between schizophrenia and the Big Five personality traits using a Bayesian statistical framework. Using summary statistics from genome-wide association studies (GWAS) on personality traits in the 23andMe cohort (n = 59,225) and schizophrenia in the Psychiatric Genomics Consortium cohort (n = 82,315), we evaluated overlap in common genetic variants. The Big Five personality traits neuroticism, extraversion, openness, agreeableness and conscientiousness were measured using a web implementation of the Big Five Inventory. Applying the conditional false discovery rate approach, we increased discovery of genetic loci and identified two loci shared between neuroticism and schizophrenia and six loci shared between openness and schizophrenia. The study provides new insights into the relationship between personality traits and schizophrenia by highlighting genetic loci involved in their common genetic etiology.en_US
dc.publisherNature Publishing Groupeng
dc.rightsAttribution CC BYeng
dc.titleIdentification of genetic loci shared between schizophrenia and the Big Five personality traitsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2017 The Author(s)
dc.source.journalScientific Reports
dc.relation.projectHelse Sør-Øst RHF: 2016-064
dc.relation.projectHelse Sør-Øst RHF: 2017-004

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