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dc.contributor.authorDembinski, Jennifer Lynnen_US
dc.contributor.authorMihret, Adaneen_US
dc.contributor.authorYimer, Solomon Abebeen_US
dc.contributor.authorTessema, Bamlaken_US
dc.contributor.authorTrieu, Mai Chien_US
dc.contributor.authorTarekegn, Azeben_US
dc.contributor.authorGetachew, Nahomen_US
dc.contributor.authorCox, Rebecca Janeen_US
dc.contributor.authorOftung, Fredriken_US
dc.contributor.authorHaneberg, Bjørnen_US
dc.contributor.authorAseffa, Abrahamen_US
dc.contributor.authorMjaaland, Sirien_US
dc.PublishedDembinski JL, Mihret A, Yimer SA, Tessema, Trieu MC, Tarekegn, Getachew, Cox RJ, Oftung F, Haneberg B, Aseffa A, Mjaaland S. High prevalence of humoral and cellular immunity to influenza viruses in pre-school children living in Addis Ababa, Ethiopia. Open Forum Infectious Diseases. 2017;4(1):ofx026eng
dc.description.abstractBackground. Influenza in children who reside in tropical and subtropical regions has until recently been regarded as insignificant. However, new evidence suggests that it significantly impacts hospitalization and promotes secondary bacterial coinfections. Ethiopia is situated in a subtropical area where influenza viruses are likely to circulate year round. Methods. Clinical data were recorded in a cohort of 103 healthy preschool children recruited in Addis Ababa, Ethiopia. Humoral and cellular immune responses to influenza virus were determined by hemagglutination inhibition (HI) and interferon-γ enzyme-linked immunospot assays. Results. Ninety-six percent of the children (2–5 years old) had pre-existing HI antibody responses to 1 or more of the circulating influenza A subtypes, H1N1 (51%), H3N2 (86%), or influenza B (51%) strains. At the age of 4, all children had been infected with at least 1 strain, and 75% had been infected with 2–4 different viral strains. CD4+ and CD8+ T-cell responses against conserved viral antigens increased with repeated exposures, indicating boosting of cross-reactive cellular immunity. Malnutrition did not seem to affect these immune responses to influenza. Conclusions. Influenza is highly prevalent among children in this area of Ethiopia. Due to the risk of secondary bacterial pneumonia, increased influenza awareness might benefit child health.en_US
dc.publisherOxford University Presseng
dc.rightsAttribution CC BY-NC-NDeng
dc.subjectimmune responseseng
dc.titleHigh prevalence of humoral and cellular immunity to influenza viruses in pre-school children living in Addis Ababa, Ethiopiaen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2017 The Author(s)
dc.source.journalOpen Forum Infectious Diseases
dc.relation.projectNorges forskningsråd: 249062
dc.relation.projectNorges forskningsråd: 220670

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