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dc.contributor.authorLandskron, Johannesen_US
dc.contributor.authorKraggerud, Sigrid M.en_US
dc.contributor.authorWik, Elisabethen_US
dc.contributor.authorDørum, Anneen_US
dc.contributor.authorBjørnslett, Merete Paulineen_US
dc.contributor.authorMelum, Espenen_US
dc.contributor.authorHelland, Øysteinen_US
dc.contributor.authorBjørge, Lineen_US
dc.contributor.authorLothe, Ragnhild Aen_US
dc.contributor.authorSalvesen, Helgaen_US
dc.contributor.authorTasken, Kjetilen_US
dc.PublishedLandskron J, Kraggerud SM, Wik E, Dørum A, Bjørnslett MP, Melum E, Helland Ø, Bjørge L, Lothe RA, Salvesen H, Tasken K. C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease. PLoS ONE. 2017;12(7):e0182030eng
dc.description.abstractThe pan lymphocyte marker CD45 exists in various isoforms arising from alternative splicing of the exons 4, 5 and 6. While naïve T cells express CD45RA translated from an mRNA containing exon 4, exons 4–6 are spliced out to encode the shorter CD45R0 in antigen-experienced effector/memory T cells. The SNP C77G (rs17612648) is located in exon 4 and blocks the exon’s differential splicing from the pre-mRNA, enforcing expression of CD45RA. Several studies have linked C77G to autoimmune diseases but lack of validation in other cohorts has left its role elusive. An incidental finding in an ovarian cancer patient cohort from West Norway (Bergen region, n = 312), suggested that the frequency of C77G was higher among ovarian cancer patients than in healthy Norwegians (n = 1,357) (3.0% vs. 1.8% allele frequency). However, this finding could not be validated in a larger patient cohort from South-East Norway (Oslo region, n = 1,198) with 1.2% allele frequency. Hence, C77G is not associated with ovarian cancer in the Norwegian population. However, its frequency was increased in patients with FIGO stage II, endometrioid histology or an age at diagnosis of 60 years or older indicating a possible association with a less aggressive cancer type.en_US
dc.rightsAttribution CC BYeng
dc.titleC77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive diseaseen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2017 The Author(s)
dc.source.journalPLoS ONE
dc.relation.projectNorges forskningsråd: 144182
dc.relation.projectNorges forskningsråd: 179571

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