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dc.contributor.authorHove-Skovsgaard, Maleneen_US
dc.contributor.authorGaardbo, Julie Christineen_US
dc.contributor.authorKolte, Lilianen_US
dc.contributor.authorWinding, Kamillaen_US
dc.contributor.authorSeljeflot, Ingebjørgen_US
dc.contributor.authorSvardal, Asbjørn M.en_US
dc.contributor.authorBerge, Rolf Kristianen_US
dc.contributor.authorGerstoft, Janen_US
dc.contributor.authorUllum, Henriken_US
dc.contributor.authorTrøseid, Mariusen_US
dc.contributor.authorNielsen, Susanne Damen_US
dc.PublishedHove-Skovsgaard, Gaardbo, Kolte, Winding, Seljeflot I, Svardal AM, Berge RK, Gerstoft J, Ullum H, Trøseid M, Nielsen SD. HIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation. BMC Infectious Diseases. 2017;17:234eng
dc.description.abstractBackground: Increased incidence of cardiovascular diseases (CVD) in both HIV infection and type 2 diabetes (T2D) compared to the general population has been described. Little is known about the combined effect of HIV infection and T2D on inflammation and endothelial function, both of which may contribute to elevated risk of CVD. Methods: Cross-sectional study including 50 HIV-infected persons on combination anti-retroviral therapy (cART), with HIV RNA <200 copies/mL (n = 25 with T2D (HIV + T2D+), n = 25 without T2D (HIV + T2D-)) and 50 uninfected persons (n = 22 with T2D (HIV-T2D+) and n = 28 without T2D (HIV-T2D-)). Groups were matched on age and sex. High sensitive C-reactive protein (hsCRP) was used to determine inflammation (cut-off 3 mg/L). The marker of endothelial dysfunction asymmetric dimethylarginine (ADMA) was measured using high performance liquid chromatography. Trimethylamine-N-oxide (TMAO), a microbiota-dependent, pro-atherogenic marker was measured using stable isotope dilution LC/MS/MS. Results: The percentage of HIV + T2D+, HIV + T2D-, HIV-T2D+, and HIV-T2D- with hsCRP above cut-off was 50%, 19%, 47%, and 11%, respectively. HIV + T2D+ had elevated ADMA (0.67 μM (0.63-0.72) compared to HIV + T2D- (0.60 μM (0.57-0.64) p = 0.017), HIV-T2D+ (0.57 μM (0.51-63) p = 0.008), and HIV-T2D- (0.55 μM (0.52-0.58) p < 0.001). No differences in TMAO between groups were found. However, a positive correlation between ADMA and TMAO was found in the total population (rs = 0.32, p = 0.001), which was mainly driven by a close correlation in HIV + T2D+ (rs = 0.63, p = 0.001). Conclusion: Elevated inflammation and evidence of endothelial dysfunction was found in HIV-infected persons with T2D. The effect on inflammation was mainly driven by T2D, while both HIV infection and T2D may contribute to endothelial dysfunction. Whether gut microbiota is a contributing factor to this remains to be determined.en_US
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.subjectHIV infectioneng
dc.subjectType 2 diabeteseng
dc.titleHIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammationen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2017 The Author(s)
dc.source.journalBMC Infectious Diseases

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