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dc.contributor.authorBruserud, Øyvinden_US
dc.contributor.authorSiddiqui, Humaen_US
dc.contributor.authorMarthinussen, Michaela Cuidaen_US
dc.contributor.authorChen, Tsuteen_US
dc.contributor.authorJonsson, Rolanden_US
dc.contributor.authorOftedal, Bergithe Eikelanden_US
dc.contributor.authorOlsen, Ingaren_US
dc.contributor.authorHusebye, Eystein Sverreen_US
dc.contributor.authorWolff, Anette Bøeen_US
dc.PublishedBruserud Ø, Siddiqui H, Marthinussen, Chen T, Jonsson R, Oftedal BE, Olsen I, Husebye ES, Wolff. Oral microbiota in autoimmune polyendocrine syndrome type 1. Journal of Oral Microbiology. 2018;10:1442986eng
dc.description.abstractBackground: Autoimmune polyendocrine syndrome type-1 (APS-1) is a rare, childhood onset disease caused by mutations in the Autoimmune Regulator gene. The phenotypic expression is highly variable and includes disease manifestations in the oral cavity, including mucocutaneous candidiasis. Increasing evidence suggests a potential role of the skin, oral and gut microbiotas in the pathogenesis of autoimmunity. To date, no information exists regarding the oral microbiota in APS-1. Objective: To assess the bacterial microbiota of whole saliva in APS-1 patients by using high throughput sequencing. Design: Whole unstimulated saliva was collected from 10 APS-1 patients and 17 healthy controls and examined by high throughput sequencing of the hypervariable region V1-V2 of 16S rRNA using the 454 GS Junior system. Metastats ( was used to analyse the pyrosequencing reads. Results: A reduction in the total number of bacterial genera and species was detected in APS-1 compared to healthy controls. The proportion of the major phyla Firmicutes was higher (60% vs 41%, p = 0.002) and Bacteroidetes lower (15% vs 28%, p = 0.007) in APS-1 compared to healthy controls. On the genus level, Streptococcus and Gemella were prevalent in APS-1. Conclusion: Our findings indicate a significantly altered oral microbiota in APS-1.en_US
dc.publisherTaylor & Franciseng
dc.rightsAttribution CC BYeng
dc.subjectwhole salivaeng
dc.subjecthigh throughput sequencingeng
dc.titleOral microbiota in autoimmune polyendocrine syndrome type 1en_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2018 The Author(s)
dc.source.journalJournal of Oral Microbiology

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