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dc.contributor.authorMidttun, Øivinden_US
dc.contributor.authorTheofylaktopoulou, Despoinaen_US
dc.contributor.authorMccann, Adrianen_US
dc.contributor.authorFanidi, Anouaren_US
dc.contributor.authorMuller, David C.en_US
dc.contributor.authorMeyer, Klausen_US
dc.contributor.authorUlvik, Arveen_US
dc.contributor.authorZheng, Weien_US
dc.contributor.authorShu, Xiao-Ouen_US
dc.contributor.authorXiang, Yong-Bingen_US
dc.contributor.authorPrentice, Rossen_US
dc.contributor.authorThomson, Cynthia A.en_US
dc.contributor.authorPettinger, Maryen_US
dc.contributor.authorGiles, Graham G.en_US
dc.contributor.authorHodge, Allisonen_US
dc.contributor.authorCai, Qiuyinen_US
dc.contributor.authorBlot, William J.en_US
dc.contributor.authorWu, Jieen_US
dc.contributor.authorJohansson, Mikaelen_US
dc.contributor.authorHultdin, Johanen_US
dc.contributor.authorGrankvist, Kjellen_US
dc.contributor.authorStevens, Victoria L.en_US
dc.contributor.authorMcCullough, Marjorie L.en_US
dc.contributor.authorWeinstein, Stephanie J.en_US
dc.contributor.authorAlbanes, Demetriusen_US
dc.contributor.authorLanghammer, Arnulfen_US
dc.contributor.authorHveem, Kristianen_US
dc.contributor.authorNæss, Mariten_US
dc.contributor.authorSesso, Howard D.en_US
dc.contributor.authorGaziano, J. Michaelen_US
dc.contributor.authorBuring, Julie E.en_US
dc.contributor.authorLee, I-Minen_US
dc.contributor.authorSeveri, Gianlucaen_US
dc.contributor.authorZhang, Xuehongen_US
dc.contributor.authorHan, Jialien_US
dc.contributor.authorStampfer, Meir J.en_US
dc.contributor.authorSmith-Warner, Stephanie A.en_US
dc.contributor.authorZeleniuch-Jacquotte, Anneen_US
dc.contributor.authorLe Marchand, Loicen_US
dc.contributor.authorYuan, Jian-Minen_US
dc.contributor.authorButler, Lesley M.en_US
dc.contributor.authorKoh, Woon-Puayen_US
dc.contributor.authorWang, Renweien_US
dc.contributor.authorGao, Yu-Tangen_US
dc.contributor.authorEricson, Ulrikaen_US
dc.contributor.authorSonestedt, Emilyen_US
dc.contributor.authorZiegler, Regina G.en_US
dc.contributor.authorFreedman, Neal D.en_US
dc.contributor.authorVisvanathan, Kalaen_US
dc.contributor.authorJones, Miranda R.en_US
dc.contributor.authorRelton, Carolineen_US
dc.contributor.authorBrennan, Paulen_US
dc.contributor.authorJohansson, Mattiasen_US
dc.contributor.authorUeland, Per Magneen_US
dc.PublishedMidttun Ø, Theofylaktopoulou D, Mccann A, Fanidi A, Muller DC, Meyer K, Ulvik A, Zheng W, Shu X, Xiang Y, Prentice R, Thomson, Pettinger M, Giles GG, Hodge A, Cai Q, Blot WJ, Wu J, Johansson M, Hultdin J, Grankvist K, Stevens VL, McCullough ML, Weinstein SJ, Albanes D, Langhammer A, Hveem K, Næss M, Sesso HD, Gaziano, Buring JE, Lee I, Severi G, Zhang X, Han J, Stampfer MJ, Smith-Warner, Zeleniuch-Jacquotte A, Le Marchand L, Yuan J, Butler LM, Koh W, Wang R, Gao Y, Ericson U, Sonestedt E, Ziegler RG, Freedman ND, Visvanathan K, Jones, Relton C, Brennan P, Johansson M, Ueland PM. Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations. American Journal of Clinical Nutrition. 2017;105(6):1314-1326eng
dc.description.abstractBackground: Circulating concentrations of biomarkers that are related to vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5′-phosphate, folate, vitamin B-12, all-trans retinol, 25-hydroxyvitamin D, and α-tocopherol as well as combined vitamin scores that were based on these nutrients showed that the general B-vitamin concentration was highest in the United States and that the B vitamins and lipid soluble vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-vitamin concentration in the United States appears to be driven mainly by multivitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of vitamins and, in particular, the widespread multivitamin-supplement use in the United States. The results provide valuable information about the differences in biomarker concentrations in populations across continents.en_US
dc.publisherOxford University Presseng
dc.rightsAttribution CC BYeng
dc.subjectLung Cancer Cohort Consortiumeng
dc.subjectone-carbon metabolismeng
dc.subjecttryptophan metabolismeng
dc.subjectvitamin statuseng
dc.titleCirculating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populationsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2017 American Society for Nutrition
dc.source.journalAmerican Journal of Clinical Nutrition

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